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Dolk Gene Detail
Summary
  • Symbol
    Dolk
  • Name
    dolichol kinase
  • Synonyms
    MGC:36683, mKIAA1094, Tmem15
  • Feature Type
    protein coding gene
  • IDs
    MGI:2677836
    NCBI Gene: 227697
  • Gene Overview
    MyGene.info: DOLK
Location & Maps
more
  • Sequence Map
    Chr2:30284231-30286334 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2104 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 21.49 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DOLK, dolichol kinase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    DOLK, dolichol kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDG1M, DK, DK1, SEC59, TMEM15
  • Links
    NCBI Gene ID: 22845
    neXtProt AC: NX_Q9UPQ8

  • Chr Location
    9q34.11; chr9:128945530-128947733 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8940
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;2 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: DOLK
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human DOLK associations

Human Disease Mouse Models
       Congenital Disorder of Glycosylation, Type Im; CDG1M   OMIM: 610768
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
  • All Mutations and Alleles
    2
  • Endonuclease-mediated
    1
  • Targeted
    1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016769 VEGA Gene Model | MGI Sequence Detail 2104 C57BL/6J ±  kb
transcript OTTMUST00000040713 VEGA | MGI Sequence Detail 2104 Not Applicable  
polypeptide OTTMUSP00000018203 VEGA | MGI Sequence Detail 534 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 47
    cDNA 47

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory