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Thoc6
Gene Detail
Symbol

Name
ID
Thoc6
THO complex 6 homolog (Drosophila)
MGI:2677480
Synonyms
F830014G06Rik, Wdr58
Feature Type
protein coding gene
Genetic Map
Chromosome 17
11.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:23668614-23673882 bp, - strand
From VEGA annotation of GRCm38

  5269 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: THOC6
Gene Tree: Thoc6

Human
homologs
THOC6, THO complex 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79228
neXtProt AC: NX_Q86W42

Human Synonyms: BBIS, fSAP35, WDR58

Human Chr (Location): 16p13.3; chr16:3024031-3027755 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human THOC6

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Thoc6 interacts with 20 markers (Mir22, Mir99a, Mir100, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process apoptotic process, central nervous system development, ...
Component nucleoplasm, nucleus, ...
Function protein binding, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(46)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase thoc6    NEW 
Molecular
reagents
All nucleic(46) cDNA(46)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023716 (Evidence)
Ensembl Gene Model ENSMUSG00000041319 (Evidence)
Entrez Gene 386612 (Evidence)
UniGene 328831
NIA Mouse Gene Index U037499
Consensus CDS Project CCDS28454.1
International Mouse Phenotyping Consortium Status Thoc6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023716 VEGA Gene Model | MGI Sequence Detail 5269 C57BL/6J ±  kb
transcript OTTMUST00000057916 VEGA | MGI Sequence Detail 1504 Not Applicable 
polypeptide OTTMUSP00000028009 VEGA | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000016315 THO complex subunit 6
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:204143 Wang L, et al., The THO Complex Regulates Pluripotency Gene mRNA Export and Controls Embryonic Stem Cell Self-Renewal and Somatic Cell Reprogramming. Cell Stem Cell. 2013 Dec 5;13(6):676-90
All references(24)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory