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Thoc6 Gene Detail
Summary
  • Symbol
    Thoc6
  • Name
    THO complex 6
  • Synonyms
    F830014G06Rik, Wdr58
  • Feature Type
    protein coding gene
  • IDs
    MGI:2677480
    NCBI Gene: 386612
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:23668614-23673882 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 11.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2677480
protein coding gene Chr17:23668614-23673903 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023261
protein coding gene Chr17:22582519-22589257 (-)
A/J MGP_AJ_G0023221
protein coding gene Chr17:21933345-21939512 (-)
AKR/J MGP_AKRJ_G0023191
protein coding gene Chr17:22010617-22015850 (-)
BALB/cJ MGP_BALBcJ_G0023226
protein coding gene Chr17:22148648-22153944 (-)
C3H/HeJ MGP_C3HHeJ_G0022986
protein coding gene Chr17:22371419-22377354 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023669
protein coding gene Chr17:23564480-23570755 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021150
protein coding gene Chr17:19503519-19508546 (-)
CAST/EiJ MGP_CASTEiJ_G0022492
protein coding gene Chr17:22205133-22210205 (-)
CBA/J MGP_CBAJ_G0022962
protein coding gene Chr17:24375998-24381131 (-)
DBA/2J MGP_DBA2J_G0023094
protein coding gene Chr17:21562689-21567810 (-)
FVB/NJ MGP_FVBNJ_G0023061
protein coding gene Chr17:21287437-21292462 (-)
LP/J MGP_LPJ_G0023168
protein coding gene Chr17:22842198-22847335 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023080
protein coding gene Chr17:24138541-24143637 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023708
protein coding gene Chr17:22302539-22309130 (-)
PWK/PhJ MGP_PWKPhJ_G0022240
protein coding gene Chr17:20347548-20352864 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022060
protein coding gene Chr17:20327844-20332985 (-)
WSB/EiJ MGP_WSBEiJ_G0022555
protein coding gene Chr17:22358201-22364318 (-)



Homology
more
  • Human Ortholog
    THOC6, THO complex 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    THOC6, THO complex 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    fSAP35, WDR58
  • Links
    NCBI Gene ID: 79228
    neXtProt AC: NX_Q86W42
    UniProt: Q86W42

  • Chr Location
    16p13.3; chr16:3024031-3027755 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041319 Ensembl Gene Model | MGI Sequence Detail 5269 C57BL/6J ±  kb
transcript ENSMUST00000047436 Ensembl | MGI Sequence Detail 1504 Not Applicable  
polypeptide ENSMUSP00000038137 Ensembl | MGI Sequence Detail 341 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    cDNA 46

    Microarray probesets 3
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:204143 Wang L, et al., The THO Complex Regulates Pluripotency Gene mRNA Export and Controls Embryonic Stem Cell Self-Renewal and Somatic Cell Reprogramming. Cell Stem Cell. 2013 Dec 5;13(6):676-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory