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Thoc6
Gene Detail
Symbol

Name
ID
Thoc6
THO complex 6 homolog (Drosophila)
MGI:2677480
Synonyms
F830014G06Rik, Wdr58
Feature Type
protein coding gene
Genetic Map
Chromosome 17
11.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:23668614-23673882 bp, - strand
From VEGA annotation of GRCm38

  5269 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Thoc6

Human
homologs
Human Homolog THOC6, THO complex 6 homolog (Drosophila)
NCBI Gene ID 79228
neXtProt AC  NX_Q86W42
Human Synonyms  BBIS, fSAP35, WDR58
Human Chr (Location)  16p13.3; chr16:3024031-3027755 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human THOC6
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(3) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Thoc6 interacts with 20 markers (Mir22, Mir99a, Mir100, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process apoptotic process, central nervous system development, ...
Component nucleus, THO complex, ...
Function protein binding, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(46)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(46) cDNA(46)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023716 (Evidence)
Ensembl Gene ModelENSMUSG00000041319 (Evidence)
Entrez Gene386612 (Evidence)
UniGene328831
NIA Mouse Gene IndexU037499
Consensus CDS ProjectCCDS28454.1
International Mouse Knockout Project StatusThoc6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023716 VEGA Gene Model | MGI Sequence Detail 5269 C57BL/6J ±  kb
transcript OTTMUST00000057916 VEGA | MGI Sequence Detail 1504 Not Applicable 
polypeptide OTTMUSP00000028009 VEGA | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000016315 THO complex subunit 6
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:204143 Wang L, et al., The THO Complex Regulates Pluripotency Gene mRNA Export and Controls Embryonic Stem Cell Self-Renewal and Somatic Cell Reprogramming. Cell Stem Cell. 2013 Dec 5;13(6):676-90
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory