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Dagla
Gene Detail
 Symbol
Name
ID
Dagla
diacylglycerol lipase, alpha
MGI:2677061
Synonyms Nsddr
Feature Type protein coding gene
Genetic Map
Chromosome 19
6.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:10245265-10304877 bp, - strand
From VEGA annotation of GRCm38

  59613 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4468  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dagla

Human
homologs
Human Homolog DAGLA, diacylglycerol lipase, alpha
NCBI Gene ID 747
neXtProt AC  NX_Q9Y4D2
Human Synonyms  C11orf11, DAGLALPHA, DAGL(ALPHA), NSDDR
Human Chr (Location)  11q12.2; chr11:61680433-61747002 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(12) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null mutations have decreased body weight, adult neuronal proliferation, and nervous system endocannaboid levels and abnormal inhibitory postsynaptic currents.
 
Interactions
Dagla interacts with 315 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process arachidonic acid metabolic process, diacylglycerol catabolic process, ...
Component bounding membrane of organelle, integral component of membrane, ...
Function 1-oxa-2-oxocycloheptane lactonase activity, 3,4-dihydrocoumarin hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (20)    Tissues (3)    Images (11)
Theiler Stages: 23
Assay TypeResults
RNA in situ 20
cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(36) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021192 (Evidence)
Ensembl Gene ModelENSMUSG00000035735 (Evidence)
Entrez Gene269060 (Evidence)
UniGene329718
DFCITC1602538
DoTSDT.101316098, DT.110846264
NIA Mouse Gene IndexU038800
EC3.1.1.-
Consensus CDS ProjectCCDS29574.1
International Mouse Knockout Project StatusDagla
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021192 VEGA Gene Model | MGI Sequence Detail 59613 C57BL/6J ±  kb
transcript OTTMUST00000050204 VEGA | MGI Sequence Detail 5634 Not Applicable 
polypeptide OTTMUSP00000023405 VEGA | MGI Sequence Detail 1044 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(181 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002921 Lipase, class 3
Protein Ontology PR:000006268 sn1-specific diacylglycerol lipase alpha
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:195134 Sugaya Y, et al., The endocannabinoid 2-arachidonoylglycerol negatively regulates habituation by suppressing excitatory recurrent network activity and reducing long-term potentiation in the dentate gyrus. J Neurosci. 2013 Feb 20;33(8):3588-601
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory