About   Help   FAQ
Mir22 Gene Detail
Summary
  • Symbol
    Mir22
  • Name
    microRNA 22
  • Synonyms
    Mirn22, mmu-mir-22
  • Feature Type
    miRNA gene
  • IDs
    MGI:2676896
    NCBI Gene: 387141
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:75354542-75354636 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676896
miRNA gene Chr11:75354542-75354636 (+)
129S1/SvImJ MGP_129S1SvImJ_G0007842
miRNA gene Chr11:76210792-76210886 (+)
A/J MGP_AJ_G0007837
miRNA gene Chr11:73379171-73379265 (+)
AKR/J MGP_AKRJ_G0007812
miRNA gene Chr11:75598981-75599075 (+)
BALB/cJ MGP_BALBcJ_G0007815
miRNA gene Chr11:73750371-73750465 (+)
C3H/HeJ MGP_C3HHeJ_G0007762
miRNA gene Chr11:75615843-75615937 (+)
C57BL/6NJ MGP_C57BL6NJ_G0007993
miRNA gene Chr11:78596318-78596412 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0007137
miRNA gene Chr11:70389106-70389200 (+)
CAST/EiJ MGP_CASTEiJ_G0007655
miRNA gene Chr11:76008782-76008876 (+)
CBA/J MGP_CBAJ_G0007733
miRNA gene Chr11:82048620-82048714 (+)
DBA/2J MGP_DBA2J_G0007768
miRNA gene Chr11:72983952-72984046 (+)
FVB/NJ MGP_FVBNJ_G0007786
miRNA gene Chr11:72543699-72543793 (+)
LP/J MGP_LPJ_G0007846
miRNA gene Chr11:76800359-76800453 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0007756
miRNA gene Chr11:82614443-82614537 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0007990
miRNA gene Chr11:75808176-75808270 (+)
PWK/PhJ MGP_PWKPhJ_G0007583
miRNA gene Chr11:73679645-73679739 (+)
SPRET/EiJ MGP_SPRETEiJ_G0007478
miRNA gene Chr11:75361233-75361327 (+)
WSB/EiJ MGP_WSBEiJ_G0007723
miRNA gene Chr11:75615404-75615498 (+)



Homology
more
  • Human Ortholog
    MIR22, microRNA 22
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR22, microRNA 22
  • Synonyms
    hsa-mir-22, miR-22, MIRN22
  • Links
    NCBI Gene ID: 407004

  • Chr Location
    chr17:1713903-1713987 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired cardiac function following treatment with dobutamine or transverse aortic constriction. Another homozygous knock-out allele shows altered cardiac responses to isoproterenol-induced stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 387141 NCBI Gene Model | MGI Sequence Detail 95 C57BL/6J ±  kb
    transcript NR_029739 RefSeq | MGI Sequence Detail 95 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 2
      Primer pair 1
      Other 1
    Other Database
    Links
    less
    miRBase MI0000570
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 30
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345720 de Sousa E, et al., Sex-specific regulation of miR-22 and ERalpha in white adipose tissue of obese dam's female offspring impairs the early postnatal development of functional beige adipocytes in mice. Biochim Biophys Acta Mol Basis Dis. 2024 Feb 7;1870(4):167057

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory