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Nlrp12
Gene Detail
Symbol

Name
ID
Nlrp12
NLR family, pyrin domain containing 12
MGI:2676630
Synonyms
Nalp12
Feature Type
protein coding gene
Genetic Map
Chromosome 7
1.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:3221510-3249740 bp, - strand
From NCBI annotation of GRCm38

  28231 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16972  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog

Protein SuperFamily: NALP protein
Gene Tree: Nlrp12

Human
homologs
Human Homolog NLRP12, NLR family, pyrin domain containing 12
NCBI Gene ID 91662
neXtProt AC  NX_P59046
Human Synonyms  CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2
Human Chr (Location)  19q13.42; chr19:53793584-53824403 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NLRP12
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(15) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele have defects in dendritic and myeloid cell migration and a decreased susceptibility to type IV hypersensitivity reactions. Mice homozygous for a second null allele display increased susceptibility to induced colitis and to chemically-induced tumors.
 
Interactions
Nlrp12 interacts with 160 markers (Mir18, Mir18b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cellular response to cytokine stimulus, dendritic cell migration, ...
Component cytoplasm
Function ATP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Other database
links
Ensembl Gene ModelENSMUSG00000078817 (Evidence)
Entrez Gene378425 (Evidence)
UniGene277152
DFCITC1738725
DoTSDT.101172616, DT.101283636, DT.94282143
NIA Mouse Gene IndexU277148
Consensus CDS ProjectCCDS51963.1
International Mouse Knockout Project StatusNlrp12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 378425 NCBI Gene Model | MGI Sequence Detail 28231 C57BL/6J ±  kb
transcript NM_001033431 RefSeq | MGI Sequence Detail 4329 C57BL/6 
polypeptide E9Q5R7 UniProt | EBI | MGI Sequence Detail 1054 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(7) UniProt(5)
Polymorphisms
SNPs within 2kb(222 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004020 DAPIN domain
InterPro IPR011029 Death-like domain
InterPro IPR001611 Leucine-rich repeat
InterPro IPR007111 NACHT nucleoside triphosphatase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000011267 NACHT, LRR and PYD domains-containing protein 12
Graphical View of Protein Domain Structure
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:211055 Weng D, et al., Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7391-6
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory