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Nlrp12 Gene Detail
Summary
  • Symbol
    Nlrp12
  • Name
    NLR family, pyrin domain containing 12
  • Synonyms
    Nalp12
Location &
Maps
more
  • Sequence Map
    Chr7:3267458-3298370 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 1.88 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    231 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676630
 protein coding gene Chr7:3267317-3298400 (-)
129S1/SvImJ ENSMUSG00200037580
 protein coding gene Chr7:176872-207449 (-)
A/J ENSMUSG00195050135
 protein coding gene Chr7:95465-126242 (-)
AKR/J ENSMUSG00220024956
 protein coding gene Chr7:3899957-3930739 (+)
BALB/cJ ENSMUSG00180041037
 protein coding gene Chr7:95393-125981 (-)
C3H/HeJ ENSMUSG00175040242
 protein coding gene Chr7:95365-125955 (-)
C57BL/6NJ ENSMUSG00215038996
 protein coding gene Chr7:88980-119778 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029084
 protein coding gene Chr7:25517-55496 (-)
CAST/EiJ ENSTCUG00005023672
 protein coding gene Chr7:100715-131758 (-)
CBA/J ENSMUSG00210045732
 protein coding gene Chr7:95310-125906 (-)
DBA/2J ENSMUSG00185040926
 protein coding gene Chr7:280725-311323 (-)
FVB/NJ ENSMUSG00205033273
 protein coding gene Chr7:94835-121765 (-)
JF1/MsJ ENSUMUG00000035869
 protein coding gene Chr7:302931-333421 (-)
LP/J ENSMUSG00230037717
 protein coding gene Chr7:3294839-3325424 (-)
NOD/ShiLtJ ENSMUSG00190031061
 protein coding gene Chr7:95443-126228 (-)
NZO/HlLtJ ENSMUSG00225017893
 protein coding gene Chr7:1103266-1133727 (-)
PWK/PhJ ENSLUMG00010038897
 protein coding gene Chr7:3806044-3836689 (-)
SPRET/EiJ ENSMSPG00010044926
 protein coding gene Chr7:299578-330862 (-)
WSB/EiJ ENSIUOG00005051205
 protein coding gene Chr7:88707-119424 (-)



Homology
more
  • Human Ortholog
    NLRP12, NLR family pyrin domain containing 12
  • Vertebrate Orthologs
    48
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRP12, NLR family pyrin domain containing 12
  • Synonyms
    CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2
  • Links
    NCBI Gene ID: 91662
    UniProt: P59046

  • Chr Location
    19q13.42; chr19:53792139-53824403 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NLRP12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    105 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have defects in dendritic and myeloid cell migration and a decreased susceptibility to type IV hypersensitivity reactions. Mice homozygous for a second null allele display increased susceptibility to induced colitis and to chemically-induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    15
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000078817 Ensembl Gene Model | MGI Sequence Detail 30913 C57BL/6J ±  kb
    transcript ENSMUST00000108653 Ensembl | MGI Sequence Detail 6928 Not Applicable  
    polypeptide ENSMUSP00000104293 Ensembl | MGI Sequence Detail 1054 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000011267 NACHT, LRR and PYD domains-containing protein 12
      (term hierarchy)
    • InterPro Domains
      IPR004020 DAPIN domain
      IPR011029 Death-like domain superfamily
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR029495 NACHT-associated domain
      IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
      IPR007111 NACHT nucleoside triphosphatase
      IPR050637 NLRP family, innate immunity and inflammation regulators
      IPR041075 NOD1/2, winged helix domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15
    References
    more
    • Summaries
      All 165
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 11
      Phenotypes 105
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:386376 Faraci G, et al., The TREM2 R47H variant is associated with liver-plasma-brain axis dyshomeostasis in the 5xFAD mouse model of Alzheimer's disease. Neurobiol Aging. 2026 Apr 29;165:24-37
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory