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Nlrp12
Gene Detail
Symbol

Name
ID
Nlrp12
NLR family, pyrin domain containing 12
MGI:2676630
Synonyms
Nalp12
Feature Type
protein coding gene
Genetic Map
Chromosome 7
1.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:3221510-3249740 bp, - strand
From Ensembl annotation of GRCm38

  28231 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16972  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog

HCOP human homology predictions: NLRP12
Protein SuperFamily: NALP protein
Gene Tree: Nlrp12

Human
homologs
NLRP12, NLR family, pyrin domain containing 12
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 91662
neXtProt AC: NX_P59046

Human Synonyms: CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2

Human Chr (Location): 19q13.42; chr19:53793584-53824403 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NLRP12

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(15) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele have defects in dendritic and myeloid cell migration and a decreased susceptibility to type IV hypersensitivity reactions. Mice homozygous for a second null allele display increased susceptibility to induced colitis and to chemically-induced tumors.
 
Interactions
Nlrp12 interacts with 159 markers (Mir18, Mir18b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cellular response to cytokine stimulus, dendritic cell migration, ...
Component cytoplasm
Function ATP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Other database
links
Ensembl Gene Model ENSMUSG00000078817 (Evidence)
Entrez Gene 378425 (Evidence)
UniGene 277152
DFCI TC1738725
DoTS DT.101172616, DT.101283636, DT.94282143
NIA Mouse Gene Index U277148
Consensus CDS Project CCDS51963.1
International Mouse Phenotyping Consortium Status Nlrp12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000078817 Ensembl Gene Model | MGI Sequence Detail 28231 C57BL/6J ±  kb
transcript ENSMUST00000108653 Ensembl | MGI Sequence Detail 4329 Not Applicable 
polypeptide ENSMUSP00000104293 Ensembl | MGI Sequence Detail 1054 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(9) UniProt(5)
Polymorphisms
SNPs within 2kb(222 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004020 DAPIN domain
InterPro IPR011029 Death-like domain
InterPro IPR001611 Leucine-rich repeat
InterPro IPR029495 NACHT-associated domain
InterPro IPR007111 NACHT nucleoside triphosphatase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000011267 NACHT, LRR and PYD domains-containing protein 12
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:211055 Weng D, et al., Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7391-6
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory