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Nlrp12 Gene Detail
Summary
  • Symbol
    Nlrp12
  • Name
    NLR family, pyrin domain containing 12
  • Synonyms
    Nalp12
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676630
    NCBI Gene: 378425
  • Gene Overview
    MyGene.info: NLRP12
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:3219495-3250159 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 1.88 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    235 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676630
protein coding gene Chr7:3218784-3250159 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031514
protein coding gene Chr7:95175-128785 (-)
A/J MGP_AJ_G0031489
protein coding gene Chr7:125063-156097 (-)
AKR/J MGP_AKRJ_G0031417
protein coding gene Chr7:111814-148494 (-)
BALB/cJ MGP_BALBcJ_G0031497
protein coding gene Chr7:118258-152448 (-)
C3H/HeJ MGP_C3HHeJ_G0031217
protein coding gene Chr7:112859-145436 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031957
protein coding gene Chr7:103301-139283 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029084
protein coding gene Chr7:25517-55496 (-)
CAST/EiJ MGP_CASTEiJ_G0030586
protein coding gene Chr7:109747-146179 (-)
CBA/J MGP_CBAJ_G0031177
protein coding gene Chr7:175832-222169 (-)
DBA/2J MGP_DBA2J_G0031334
protein coding gene Chr7:104086-135839 (-)
FVB/NJ MGP_FVBNJ_G0031286
protein coding gene Chr7:112941-145144 (-)
LP/J MGP_LPJ_G0031419
protein coding gene Chr7:98992-133732 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031325
protein coding gene Chr7:132001-168653 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031991
protein coding gene Chr7:81382-118169 (-)
PWK/PhJ MGP_PWKPhJ_G0030313
protein coding gene Chr7:251316-282662 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030137
protein coding gene Chr7:154895-194395 (-)
WSB/EiJ MGP_WSBEiJ_G0030680
protein coding gene Chr7:97833-136896 (-)



Homology
more
  • Human Ortholog
    NLRP12, NLR family pyrin domain containing 12
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NLRP12, NLR family pyrin domain containing 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2
  • Links
    NCBI Gene ID: 91662
    neXtProt AC: NX_P59046
    UniProt: P59046

  • Chr Location
    19q13.42; chr19:53793584-53824403 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human NLRP12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have defects in dendritic and myeloid cell migration and a decreased susceptibility to type IV hypersensitivity reactions. Mice homozygous for a second null allele display increased susceptibility to induced colitis and to chemically-induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 378425 NCBI Gene Model | MGI Sequence Detail 30665 C57BL/6J ±  kb
transcript NM_001033431 RefSeq | MGI Sequence Detail 4329 C57BL/6  
polypeptide E9Q5R7 UniProt | EBI | MGI Sequence Detail 1054 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15
References
more
  • Summaries
    All 45
    Gene Ontology 7
    Phenotypes 22
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:257847 Hornick EE, et al., Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection. J Immunol. 2018 Feb 1;200(3):1188-1197

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory