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Akap13
Gene Detail
 Symbol
Name
ID
Akap13
A kinase (PRKA) anchor protein 13
MGI:2676556
Synonyms 1700026G02Rik, 5730522G15Rik, 5830460E08Rik, AKAP-Lbc, Ht31, PROTO-LB, PROTO-LBC
Feature Type protein coding gene
Genetic Map
Chromosome 7
43.76 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:75455534-75754609 bp, + strand
From VEGA annotation of GRCm38

  299076 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4903  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Akap13

Human
homologs
Human Homolog AKAP13, A kinase (PRKA) anchor protein 13
NCBI Gene ID 11214
neXtProt AC  NX_Q12802
Human Synonyms  AKAP-13, AKAP-Lbc, ARHGEF13, BRX, c-lbc, HA-3, Ht31, LBC, p47, PRKA13, PROTO-LB, PROTO-LBC
Human Chr (Location)  15q24-q25; chr15:85380587-85749358 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(67) : Gene trapped(66) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis, arrested heart development, and forebrain hypoplasia, Mice heterozygous for this allele exhibit small spleen, impaired lymphocyte response to osmotic stress, and decreased response to glucocorticoid.
 
Interactions
Akap13 interacts with 456 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process nuclear export, phosphorylation, ...
Component cytoplasm, membrane, ...
Function kinase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(17)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034140 (Evidence)
Ensembl Gene ModelENSMUSG00000066406 (Evidence)
Entrez Gene75547 (Evidence)
DFCITC1590701, TC1593955, TC1604785, TC1629323, TC1636632, TC1653069, TC1677797
DoTSDT.101270016, DT.101344729, DT.101347001, DT.101360570, DT.111004555, DT.40153162, DT.529784, DT.55202814, DT.87039106, DT.91335518, DT.91374192, DT.94150075
NIA Mouse Gene IndexU008235
Consensus CDS ProjectCCDS52276.1
International Mouse Knockout Project StatusAkap13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034140 VEGA Gene Model | MGI Sequence Detail 299076 C57BL/6J ±  kb
transcript OTTMUST00000086445 VEGA | MGI Sequence Detail 12597 Not Applicable 
polypeptide OTTMUSP00000046819 VEGA | MGI Sequence Detail 2794 Not Applicable 

For the selected sequences
All sequences(119) RefSeq(24) UniProt(15)
Polymorphisms SNPs within 2kb(2053 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR018459 RII binding domain
Protein Ontology PR:000003887 A-kinase anchor protein 13
References (Earliest) J:11574 Tsuchiya T, et al., In vitro reconstitution of an erythropoietin gene transcription system using its 5'-flanking sequence and a nuclear extract from anemic kidney. Biochem Biophys Res Commun. 1992 Jan 15;182(1):137-43
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(41)
Other
accession IDs
MGI:1917871, MGI:1922797, MGI:1923359

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory