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Akap13 Gene Detail
Summary
  • Symbol
    Akap13
  • Name
    A kinase (PRKA) anchor protein 13
  • Synonyms
    1700026G02Rik, 5730522G15Rik, 5830460E08Rik, AKAP-Lbc, Ht31, PROTO-LB, PROTO-LBC
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676556
    NCBI Gene: 75547
  • Gene Overview
    MyGene.info: AKAP13
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:75455534-75754609 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      299076 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 43.76 cM, cytoband D1
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    AKAP13, A-kinase anchoring protein 13
  • Vertebrate Orthologs
    8
  • Human Ortholog
    AKAP13, A-kinase anchoring protein 13
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AKAP-13, AKAP-Lbc, ARHGEF13, BRX, c-lbc, HA-3, Ht31, LBC, p47, PRKA13, PROTO-LB, PROTO-LBC
  • Links
    NCBI Gene ID: 11214
    neXtProt AC: NX_Q12802
    UniProt: Q12802

  • Chr Location
    15q25.3; chr15:85380616-85749358 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 3 genetic backgrounds
    1 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis, arrested heart development, and forebrain hypoplasia. Heterozygous mice exhibit small spleen, impaired lymphocyte response to osmotic stress, decreased response to glucocorticoid, osteoporosis and impared osteogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034140 VEGA Gene Model | MGI Sequence Detail 299076 C57BL/6J ±  kb
    transcript OTTMUST00000086445 VEGA | MGI Sequence Detail 12597 Not Applicable  
    polypeptide OTTMUSP00000046819 VEGA | MGI Sequence Detail 2794 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2045 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      14 Sequences
    • InterPro Domains
      IPR028852 A-kinase anchor protein 13
      IPR036770 Ankyrin repeat-containing domain superfamily
      IPR000219 Dbl homology (DH) domain
      IPR035899 Dbl homology (DH) domain superfamily
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 3
      cDNA 18
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917871, MGI:1922797, MGI:1923359
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 27
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:254437 Serr I, et al., A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes. Sci Transl Med. 2018 Jan 3;10(422)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory