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Dnajc13 Gene Detail
Summary
  • Symbol
    Dnajc13
  • Name
    DnaJ heat shock protein family (Hsp40) member C13
  • Synonyms
    D030002L11Rik, LOC382100, mKIAA0678, Rme8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676368
    NCBI Gene: 235567
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:104028481-104140129 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 56.61 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2697 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676368
 protein coding gene Chr9:104028481-104140807 (-)
129S1/SvImJ ENSMUSG00200016436
 protein coding gene Chr9:101189993-101285536 (-)
A/J ENSMUSG00195018498
 protein coding gene Chr9:100414620-100510173 (-)
AKR/J ENSMUSG00220038407
 protein coding gene Chr9:100804232-100899786 (-)
BALB/cJ ENSMUSG00180020059
 protein coding gene Chr9:100731134-100826688 (-)
C3H/HeJ ENSMUSG00175011772
 protein coding gene Chr9:101073776-101169312 (-)
C57BL/6NJ ENSMUSG00215011928
 protein coding gene Chr9:101065920-101161491 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032598
 protein coding gene Chr9:99571251-99677934 (-)
CAST/EiJ ENSTCUG00005013001
 protein coding gene Chr9:100873974-100963602 (-)
CBA/J ENSMUSG00210015267
 protein coding gene Chr9:100914886-101004134 (-)
DBA/2J ENSMUSG00185011925
 protein coding gene Chr9:101076056-101171594 (-)
FVB/NJ ENSMUSG00205017165
 protein coding gene Chr9:101075342-101170886 (-)
JF1/MsJ ENSUMUG00000032308
 protein coding gene Chr9:100923942-101013491 (-)
LP/J ENSMUSG00230015983
 protein coding gene Chr9:101225379-101320925 (-)
NOD/ShiLtJ ENSMUSG00190031697
 protein coding gene Chr9:100716828-100812379 (-)
NZO/HlLtJ ENSMUSG00225019476
 protein coding gene Chr9:101445506-101541053 (-)
PWK/PhJ ENSLUMG00010026328
 protein coding gene Chr9:100866827-100956049 (-)
SPRET/EiJ ENSMSPG00010043875
 protein coding gene Chr9:102733110-102849744 (-)
WSB/EiJ ENSIUOG00005022502
 protein coding gene Chr9:100150692-100239884 (-)



Homology
more
  • Human Ortholog
    DNAJC13, DnaJ heat shock protein family (Hsp40) member C13
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAJC13, DnaJ heat shock protein family (Hsp40) member C13
  • Synonyms
    PARK21, RME8
  • Links
    NCBI Gene ID: 23317
    UniProt: O75165

  • Chr Location
    3q22.1; chr3:132417502-132539032 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DNAJC13 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    2
  • cDNA Data
    149
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032560 Ensembl Gene Model | MGI Sequence Detail 111649 C57BL/6J ±  kb
    transcript ENSMUST00000186788 Ensembl | MGI Sequence Detail 6747 Not Applicable  
    polypeptide ENSMUSP00000139804 Ensembl | MGI Sequence Detail 2248 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR036869 Chaperone J-domain superfamily
      IPR001623 DnaJ domain
      IPR063268 DnaJ homolog subfamily C member 13, 4th domain
      IPR044978 DnaJ homologue subfamily C, GRV2/DNAJC13
      IPR045802 DnaJ homologue subfamily C, GRV2/DNAJC13, N-terminal domain
      IPR063244 DNAJ protein RME-8, PH domain
      IPR025640 GYF domain 2
      IPR035445 GYF-like domain superfamily
    • GlyGen
      D4AFX7 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 150
      cDNA 149
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2685970
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:381891 Swords SB, et al., A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation. Autophagy. 2024 Apr;20(4):792-808
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory