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Hsh2d
Gene Detail
 Symbol
Name
ID
Hsh2d
hematopoietic SH2 domain containing
MGI:2676364
Synonyms ALX, Hsh2
Feature Type protein coding gene
Genetic Map
Chromosome 8
34.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:72189668-72200958 bp, + strand
From NCBI annotation of GRCm38

  11291 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13142  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Hsh2d

Human
homologs
Human Homolog HSH2D, hematopoietic SH2 domain containing
NCBI Gene ID 84941
neXtProt AC  NX_Q96JZ2
Human Synonyms  ALX, HSH2
Human Chr (Location)  19p13.12; chr19:16134028-16158570 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit enhanced IL-2 production, increased T cell proliferation in response to TCR/CD28 stimulation, splenomegaly, and an increased frequency of activated T cells.
 
Interactions
Hsh2d interacts with 37 markers (Mir98, Mir125a, Mir125b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process negative regulation of B cell apoptotic process, negative regulation of mitochondrial depolarization, ...
Component cytoplasm, cytosol, ...
Function SH3/SH2 adaptor activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (12)    Tissues (12)    Images (1)
Theiler Stages: 16, 17, 18, 28
Assay TypeResults
Northern blot 12
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000062007 (Evidence)
Entrez Gene209488 (Evidence)
UniGene157431
DFCITC1589412
DoTSDT.55268638
NIA Mouse Gene IndexU009484
Consensus CDS ProjectCCDS22410.1
International Mouse Knockout Project StatusHsh2d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 209488 NCBI Gene Model | MGI Sequence Detail 11291 C57BL/6J ±  kb
transcript NM_197944 RefSeq | MGI Sequence Detail 1225 C57BL/6 
polypeptide Q6VYH9 UniProt | EBI | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(139 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000980 SH2 domain
Protein Ontology PR:000008797 hematopoietic SH2 domain-containing protein
Graphical View of Protein Domain Structure
References (Earliest) J:85736 Greene TA, et al., Cloning and characterization of ALX, an adaptor downstream of CD28. J Biol Chem. 2003 Nov 14;278(46):45128-34
(Latest) J:179338 King RG, et al., Differential expression of the adaptor protein HSH2 controls the quantitative and qualitative nature of the humoral response. J Immunol. 2011 Oct 1;187(7):3565-77
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory