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Abca12
Gene Detail
 Symbol
Name
ID
Abca12
ATP-binding cassette, sub-family A (ABC1), member 12
MGI:2676312
Synonyms 4832428G11Rik, 4833417A11Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
35.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:71243090-71414910 bp, - strand
From NCBI annotation of GRCm38

  171821 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45441  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Abca12

Human
homologs
Human Homolog ABCA12, ATP-binding cassette, sub-family A (ABC1), member 12
NCBI Gene ID 26154
neXtProt AC  NX_Q86UK0
Human Synonyms  ARCI4A, ARCI4B, ICR2B, LI2
Human Chr (Location)  2q34; chr2:214931542-215138428 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ABCA12
Alleles
and
phenotypes
All alleles(6) : Targeted(5) Chemically induced(1)
 
Mice homozygous for a null allele exhibit neonatal lethality associated with defective skin development and abnormal lung morphology.
 
Human Diseases Modeled Using Mouse Abca12 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(4)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process ceramide transport, establishment of skin barrier, ...
Component cytosol, mitochondrial inner membrane
Function ATP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (1)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000050296 (Evidence)
Entrez Gene74591 (Evidence)
UniGene159251
DFCITC1590118, TC1615815, TC1616459, TC1651535
DoTSDT.101285918, DT.101352006, DT.87054483, DT.91421336, DT.97331916
NIA Mouse Gene IndexU157376
Consensus CDS ProjectCCDS48286.1
International Mouse Knockout Project StatusAbca12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 74591 NCBI Gene Model | MGI Sequence Detail 171821 C57BL/6J ±  kb
transcript NM_175210 RefSeq | MGI Sequence Detail 8323 C57BL/6 
polypeptide NP_780419 RefSeq | MGI Sequence Detail 2595 C57BL/6 

For the selected sequences
All sequences(30) RefSeq(3) UniProt(5)
Polymorphisms SNPs within 2kb(1038 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR026082 ABC transporter A, ABCA
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003539 ATP-binding cassette sub-family A member 12
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:200990 Fu Y, et al., ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metab. 2013 Aug 6;18(2):225-38
All references(35)
Other
accession IDs
MGI:1921841, MGI:3036275

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory