About   Help   FAQ
Due to maintenance, access to MGI may be intermittent 8:00 AM ET Wed, September 18.
Muc19 Gene Detail
Summary
  • Symbol
    Muc19
  • Name
    mucin 19
  • Synonyms
    apomucin, sld
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676278
    NCBI Gene: 239611
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:91838326-91934555 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 46.14 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    459 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676278
protein coding gene Chr15:91838326-91934555 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015309
unclassified non-coding RNA gene Chr15:93224236-93264754 (+)
A/J MGP_AJ_G0015284
unclassified non-coding RNA gene Chr15:89609729-89646859 (+)
AKR/J MGP_AKRJ_G0015247
unclassified non-coding RNA gene Chr15:92266807-92310877 (+)
BALB/cJ MGP_BALBcJ_G0015247
unclassified non-coding RNA gene Chr15:89733612-89771104 (+)
C3H/HeJ MGP_C3HHeJ_G0015071
unclassified non-coding RNA gene Chr15:92291117-92328048 (+)
C57BL/6NJ MGP_C57BL6NJ_G0015701
unclassified non-coding RNA gene Chr15:96571300-96672296 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013443
unclassified non-coding RNA gene Chr15:85726046-85758586 (+)
CAST/EiJ MGP_CASTEiJ_G0014622
unclassified non-coding RNA gene Chr15:93092663-93130769 (+)
CBA/J MGP_CBAJ_G0015050
unclassified non-coding RNA gene Chr15:99864825-99928727 (+)
DBA/2J MGP_DBA2J_G0015145
unclassified non-coding RNA gene Chr15:89049910-89088422 (+)
FVB/NJ MGP_FVBNJ_G0015152
unclassified non-coding RNA gene Chr15:88088176-88124324 (+)
LP/J MGP_LPJ_G0015224
unclassified non-coding RNA gene Chr15:93361394-93401230 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015177
unclassified non-coding RNA gene Chr15:104247129-104288528 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0015740
unclassified non-coding RNA gene Chr15:92378222-92414363 (+)
PWK/PhJ MGP_PWKPhJ_G0014413
unclassified non-coding RNA gene Chr15:89106929-89144962 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014200
unclassified non-coding RNA gene Chr15:92117070-92157203 (+)
WSB/EiJ MGP_WSBEiJ_G0014729
unclassified non-coding RNA gene Chr15:92836789-92876065 (+)



Homology
more
  • Human Ortholog
    MUC19, mucin 19, oligomeric
  • Human Ortholog
    MUC19, mucin 19, oligomeric
    Orthology source: HGNC
  • Synonyms
    MUC-19
  • Links
    NCBI Gene ID: 283463
    neXtProt AC: NX_Q7Z5P9
    UniProt: Q7Z5P9

  • Chr Location
    12q12; chr12:40393394-40570757 (+)  GRCh38.p7

  • HCOP
    human homology predictions: MUC19
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Muc19 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for this spontaneous mutation show a partially arrested mucous cell differentiation of the sublingual glands. Severe inflammatory lesions resembling Sjogren's syndrome develop spontaneously in salivary and lacrimal glands of neonatally thymectomized mutants without any immunization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 239611 NCBI Gene Model | MGI Sequence Detail 96230 C57BL/6J ±  kb
    transcript AY570293 GenBank | EMBL | DDBJ | MGI Sequence Detail 22806 NFS  
    polypeptide Q6PZE0 UniProt | EBI | MGI Sequence Detail 7524 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR006207 Cystine knot, C-terminal
      IPR029034 Cystine-knot cytokine
      IPR006208 Glycoprotein hormone subunit beta
      IPR036084 Serine protease inhibitor-like superfamily
      IPR002919 Trypsin Inhibitor-like, cysteine rich domain
      IPR014853 Uncharacterised domain, cysteine-rich
      IPR001846 von Willebrand factor, type D domain
      IPR001007 VWFC domain
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 1
      cDNA 5
      Primer pair 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-14437, MGI:98316
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 1
      Diseases 5
      Gene Ontology 10
      Phenotypes 39
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    09/05/2019
    MGI 6.14
    The Jackson Laboratory