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Wapl Gene Detail
Summary
  • Symbol
    Wapl
  • Name
    WAPL cohesin release factor
  • Synonyms
    A530089A20Rik, mKIAA0261, Wapal
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675859
    NCBI Gene: 218914
  • Gene Overview
    MyGene.info: WAPL
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:34673928-34747983 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 20.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    231 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675859
protein coding gene Chr14:34673793-34747983 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021179
protein coding gene Chr14:28039731-28111318 (+)
A/J MGP_AJ_G0021127
protein coding gene Chr14:26971278-27040691 (+)
AKR/J MGP_AKRJ_G0021104
protein coding gene Chr14:28151791-28227064 (+)
BALB/cJ MGP_BALBcJ_G0021131
protein coding gene Chr14:27142000-27214356 (+)
C3H/HeJ MGP_C3HHeJ_G0020914
protein coding gene Chr14:28086517-28164842 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021563
protein coding gene Chr14:29113753-29194025 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019125
protein coding gene Chr14:26974199-27040811 (+)
CAST/EiJ MGP_CASTEiJ_G0020439
protein coding gene Chr14:27895378-27971794 (+)
CBA/J MGP_CBAJ_G0020880
protein coding gene Chr14:30186207-30264355 (+)
DBA/2J MGP_DBA2J_G0021003
protein coding gene Chr14:26997535-27063144 (+)
FVB/NJ MGP_FVBNJ_G0020987
protein coding gene Chr14:26955961-27030602 (+)
LP/J MGP_LPJ_G0021072
protein coding gene Chr14:28368207-28439887 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021013
protein coding gene Chr14:29303918-29400549 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021596
protein coding gene Chr14:27996242-28078922 (+)
PWK/PhJ MGP_PWKPhJ_G0020187
protein coding gene Chr14:26480470-26552330 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020011
protein coding gene Chr14:27592963-27662227 (+)
WSB/EiJ MGP_WSBEiJ_G0020494
protein coding gene Chr14:28039192-28120236 (+)



Homology
more
  • Human Ortholog
    WAPL, WAPL cohesin release factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WAPL, WAPL cohesin release factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FOE, KIAA0261, WAPAL
  • Links
    NCBI Gene ID: 23063
    neXtProt AC: NX_Q7Z5K2
    UniProt: Q7Z5K2

  • Chr Location
    10q23.2; chr10:86435256-86521816 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41002
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: WAPL
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit prenatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041408 Ensembl Gene Model | MGI Sequence Detail 74056 C57BL/6J ±  kb
transcript ENSMUST00000048263 Ensembl | MGI Sequence Detail 6351 Not Applicable  
polypeptide ENSMUSP00000040232 Ensembl | MGI Sequence Detail 1200 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 9
Other
Accession IDs
less
MGI:2443602
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:258320 Gassler J, et al., A mechanism of cohesin-dependent loop extrusion organizes zygotic genome architecture. EMBO J. 2017 Dec 15;36(24):3600-3618

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory