Wapl MGI Mouse Gene Detail - MGI:2675859 - WAPL cohesin release factor

Symbol

Wapl
Name

WAPL cohesin release factor
Synonyms

A530089A20Rik, mKIAA0261, Wapal

Feature Type

protein coding gene
IDs

MGI:2675859
NCBI Gene: 218914
Alliance

genome feature page
Transcription Start Sites

15 TSS
Regulated by

Rr473 (1 regulatory region)

Sequence Map

Chr14:34395885-34469940 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 20.84 cM
Mapping Data

1 experiment

SNPs within 2kb

1094 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2675859	protein coding gene	Chr14:34394086-34469940 (+)
129S1/SvImJ	ENSMUSG00200036777	protein coding gene	Chr14:26239680-26310206 (+)
A/J	ENSMUSG00195011927	protein coding gene	Chr14:27296869-27371236 (+)
AKR/J	ENSMUSG00220033193	protein coding gene	Chr14:26415640-26491202 (+)
BALB/cJ	ENSMUSG00180028338	protein coding gene	Chr14:26385362-26459719 (+)
C3H/HeJ	ENSMUSG00175037660	protein coding gene	Chr14:26452426-26526792 (+)
C57BL/6NJ	ENSMUSG00215021979	protein coding gene	Chr14:26689166-26770531 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019125	protein coding gene	Chr14:26974199-27040811 (+)
CAST/EiJ	ENSTCUG00005021789	protein coding gene	Chr14:26525066-26591315 (+)
CBA/J	ENSMUSG00210041648	protein coding gene	Chr14:26699567-26777644 (+)
DBA/2J	ENSMUSG00185014367	protein coding gene	Chr14:30971542-31038270 (+)
FVB/NJ	ENSMUSG00205016032	protein coding gene	Chr14:26557157-26627200 (+)
JF1/MsJ	ENSUMUG00000030807	protein coding gene	Chr14:38230095-38300540 (+)
LP/J	ENSMUSG00230036158	protein coding gene	Chr14:38267010-38337509 (+)
NOD/ShiLtJ	ENSMUSG00190017554	protein coding gene	Chr14:26704066-26778703 (+)
NZO/HlLtJ	ENSMUSG00225041617	protein coding gene	Chr14:32583924-32658267 (+)
PWK/PhJ	ENSLUMG00010021304	protein coding gene	Chr14:14816079-14886613 (+)
SPRET/EiJ	ENSMSPG00010038113	protein coding gene	Chr14:28386970-28454565 (+)
WSB/EiJ	ENSIUOG00005011657	protein coding gene	Chr14:26528424-26595116 (+)

Human Ortholog

WAPL, WAPL cohesin release factor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WAPL, WAPL cohesin release factor
Synonyms

FOE, KIAA0261, WAPAL
Links

HGNC:23293

NCBI Gene ID: 23063

UniProt: Q7Z5K2
Chr Location

10q23.2; chr10:86435256-86521843 (-) GRCh38

MGI Vertebrate Homology

Wapl stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: WAPL
Gene Tree

Wapl

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Phenotype Summary

6 phenotypes from 4 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

98
Endonuclease-mediated

4
Gene trapped

90
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

169 strains or lines available

Mice homozygous for a targeted allele exhibit prenatal lethality.

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All GO Annotations

68
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

697
Tissues

100
cDNA Data

13
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wapl

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All Sequences

71
RefSeq

6
UniProt

5
CCDS

CCDS36880.1, CCDS79296.1

Ensembl

ENSMUSG00000041408 (Evidence)
NCBI Gene

218914

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041408	Ensembl Gene Model \| MGI Sequence Detail	74056	C57BL/6J	± kb
transcript	ENSMUST00000048263	Ensembl \| MGI Sequence Detail	6351	Not Applicable
polypeptide	ENSMUSP00000040232	Ensembl \| MGI Sequence Detail	1200	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017368 wings apart-like protein

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR012502 WAPL domain

IPR039874 Wings apart-like protein

IPR022771 Wings apart-like protein, C-terminal
GlyGen

Q65Z40 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 14

cDNA 14

Antibodies 1

Microarray probesets 9

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MGI:2443602

Summaries

All 54

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 18
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:389188 Boone PM, et al., Clinical, in vitro, and in vivo evidence of WAPL as a cohesinopathy-associated gene and phenotypic driver of 10q22.3q23.2 genomic disorder. Am J Hum Genet. 2026 Jul 10;

Wapl expression regulated by:

Feature	Feature Type	Location	Reference
Rr473, regulatory region 473	transcription factor binding site	Chr14, Syntenic	J:294166

TSS for Wapl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125083	Chr14:34395824-34395841 (+)	-52 bp
Tssr125084	Chr14:34395845-34395887 (+)	-19 bp
Tssr125085	Chr14:34395905-34395922 (+)	29 bp
Tssr125086	Chr14:34395953-34395971 (+)	77 bp
Tssr125087	Chr14:34396011-34396022 (+)	132 bp
Tssr125088	Chr14:34396109-34396162 (+)	251 bp
Tssr125089	Chr14:34396163-34396189 (+)	291 bp
Tssr125090	Chr14:34399032-34399047 (+)	3,155 bp
Tssr125091	Chr14:34414487-34414500 (+)	18,609 bp
Tssr125092	Chr14:34416244-34416267 (+)	20,371 bp
Tssr125093	Chr14:34416958-34416970 (+)	21,079 bp
Tssr125094	Chr14:34422685-34422693 (+)	26,804 bp
Tssr125095	Chr14:34431825-34431829 (+)	35,942 bp
Tssr125096	Chr14:34436882-34436892 (+)	41,002 bp
Tssr125097	Chr14:34468793-34468798 (+)	72,911 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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