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Fez2 Gene Detail
Summary
  • Symbol
    Fez2
  • Name
    fasciculation and elongation protein zeta 2
  • Synonyms
    D17Ertd315e, zygin 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675856
    NCBI Gene: 225020
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:78676641-78725581 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 48.57 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1640 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675856
 protein coding gene Chr17:78676641-78725581 (-)
129S1/SvImJ ENSMUSG00200023841
 protein coding gene Chr17:74054170-74103080 (-)
A/J ENSMUSG00195026374
 protein coding gene Chr17:75402818-75451760 (-)
AKR/J ENSMUSG00220013087
 protein coding gene Chr17:74315156-74364079 (-)
BALB/cJ ENSMUSG00180004886
 protein coding gene Chr17:75112716-75161655 (-)
C3H/HeJ ENSMUSG00175014789
 protein coding gene Chr17:74393784-74442301 (-)
C57BL/6NJ ENSMUSG00215014068
 protein coding gene Chr17:74100976-74149913 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021885
 protein coding gene Chr17:74105993-74146366 (-)
CAST/EiJ ENSTCUG00005014507
 protein coding gene Chr17:74955190-75003695 (-)
CBA/J ENSMUSG00210020126
 protein coding gene Chr17:74257147-74305665 (-)
DBA/2J ENSMUSG00185012464
 protein coding gene Chr17:77090549-77139067 (-)
FVB/NJ ENSMUSG00205017542
 protein coding gene Chr17:74874560-74923471 (-)
JF1/MsJ ENSUMUG00000014758
 protein coding gene Chr17:76785744-76834258 (-)
LP/J ENSMUSG00230020600
 protein coding gene Chr17:78095097-78144001 (-)
NOD/ShiLtJ ENSMUSG00190009189
 protein coding gene Chr17:74158284-74207201 (-)
NZO/HlLtJ ENSMUSG00225028287
 protein coding gene Chr17:80352536-80401506 (-)
PWK/PhJ ENSLUMG00010005289
 protein coding gene Chr17:74016215-74064824 (-)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005009465
 protein coding gene Chr17:75072574-75121393 (-)



Homology
more
  • Human Ortholog
    FEZ2, fasciculation and elongation protein zeta 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FEZ2, fasciculation and elongation protein zeta 2
  • Synonyms
    HUM3CL
  • Links
    NCBI Gene ID: 9637
    UniProt: Q9UHY8

  • Chr Location
    2p22.2; chr2:36531805-36646087 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    4
  • cDNA Data
    45
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 225020 NCBI Gene Model | MGI Sequence Detail 48941 C57BL/6J ±  kb
transcript NM_001285949 RefSeq | MGI Sequence Detail 3767 ZRU/MplStud  
polypeptide Q6TYB5 UniProt | EBI | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000007467 fasciculation and elongation protein zeta-2
    (term hierarchy)
  • InterPro Domains
    IPR011680 Fasciculation and elongation protein zeta, FEZ
  • GlyGen
    Q6TYB5 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 48
    Genomic 1
    cDNA 46
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1196219
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory