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Nusap1 Gene Detail
Summary
  • Symbol
    Nusap1
  • Name
    nucleolar and spindle associated protein 1
  • Synonyms
    2610201A12Rik, NuSAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675669
    NCBI Gene: 108907
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:119618298-119650165 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 59.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    277 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675669
protein coding gene Chr2:119618298-119651244 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026347
protein coding gene Chr2:122432790-122469965 (+)
A/J MGP_AJ_G0026308
protein coding gene Chr2:117419366-117455851 (+)
AKR/J MGP_AKRJ_G0026287
protein coding gene Chr2:120699625-120737289 (+)
BALB/cJ MGP_BALBcJ_G0026321
protein coding gene Chr2:117665100-117700047 (+)
C3H/HeJ MGP_C3HHeJ_G0026067
protein coding gene Chr2:121161478-121201074 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026768
protein coding gene Chr2:126420923-126456977 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024148
protein coding gene Chr2:112455619-112486456 (+)
CAST/EiJ MGP_CASTEiJ_G0025529
protein coding gene Chr2:121481094-121518189 (+)
CBA/J MGP_CBAJ_G0026043
protein coding gene Chr2:130862335-130899755 (+)
DBA/2J MGP_DBA2J_G0026182
protein coding gene Chr2:116820702-116856021 (+)
FVB/NJ MGP_FVBNJ_G0026144
protein coding gene Chr2:115651177-115685180 (+)
LP/J MGP_LPJ_G0026283
protein coding gene Chr2:122698934-122735692 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026163
protein coding gene Chr2:135188895-135224138 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026823
protein coding gene Chr2:120814982-120852478 (+)
PWK/PhJ MGP_PWKPhJ_G0025265
protein coding gene Chr2:116405217-116438962 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025064
protein coding gene Chr2:120011288-120028380 (+)
WSB/EiJ MGP_WSBEiJ_G0025598
protein coding gene Chr2:121651709-121689663 (+)



Homology
more
  • Human Ortholog
    NUSAP1, nucleolar and spindle associated protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NUSAP1, nucleolar and spindle associated protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ANKT, BM037, LNP, NUSAP, PRO0310p1, Q0310, SAPL
  • Links
    NCBI Gene ID: 51203
    neXtProt AC: NX_Q9BXS6
    UniProt: Q9BXS6

  • Chr Location
    15q15.1; chr15:41332694-41381050 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Early embryos homozygous for a knock-out allele are small and exhibit disorganized embryonic tissue, abnormal chromatin-induced spindle assembly, abnormal inner cell mass apoptosis, and complete embryonic lethality at implantation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108907 NCBI Gene Model | MGI Sequence Detail 31868 C57BL/6J ±  kb
    transcript NM_133851 RefSeq | MGI Sequence Detail 2960 C57BL/6  
    polypeptide Q9ERH4 UniProt | EBI | MGI Sequence Detail 427 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1919720, MGI:2138984, MGI:2139379, MGI:2139440
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:241850 Naiman N, et al., Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory