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Poln Gene Detail
Summary
  • Symbol
    Poln
  • Name
    DNA polymerase N
  • Synonyms
    POL4P
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675617
    NCBI Gene: 272158
  • Gene Overview
    MyGene.info: POLN
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:34007179-34169448 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.83 cM, cytoband C1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    768 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675617
protein coding gene Chr5:34007179-34169526 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029458
protein coding gene Chr5:32209724-32378040 (-)
A/J MGP_AJ_G0029425
protein coding gene Chr5:31158684-31324389 (-)
AKR/J MGP_AKRJ_G0029374
protein coding gene Chr5:32361415-32531199 (-)
BALB/cJ MGP_BALBcJ_G0029435
protein coding gene Chr5:31686849-31863474 (-)
C3H/HeJ MGP_C3HHeJ_G0029157
protein coding gene Chr5:32395901-32571880 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029889
protein coding gene Chr5:34096497-34269648 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027126
protein coding gene Chr5:28955917-29101648 (-)
CAST/EiJ MGP_CASTEiJ_G0028566
protein coding gene Chr5:31473538-31639480 (-)
CBA/J MGP_CBAJ_G0029125
protein coding gene Chr5:34828754-35025551 (-)
DBA/2J MGP_DBA2J_G0029273
protein coding gene Chr5:31340059-31497648 (-)
FVB/NJ MGP_FVBNJ_G0029232
protein coding gene Chr5:30768049-30938075 (-)
LP/J MGP_LPJ_G0029358
protein coding gene Chr5:32633416-32801587 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029262
protein coding gene Chr5:35698782-35906058 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029922
protein coding gene Chr5:31878770-32039514 (-)
PWK/PhJ MGP_PWKPhJ_G0028291
protein coding gene Chr5:30471887-30635048 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028122
protein coding gene Chr5:31329225-31487942 (-)
WSB/EiJ MGP_WSBEiJ_G0028647
protein coding gene Chr5:31946892-32115403 (-)



Homology
more
  • Human Ortholog
    POLN, DNA polymerase nu
  • Vertebrate Orthologs
    7
  • Human Ortholog
    POLN, DNA polymerase nu
    Orthology source: HGNC
  • Synonyms
    POL4P
  • Links
    NCBI Gene ID: 353497
    neXtProt AC: NX_Q7Z5Q5
    UniProt: Q7Z5Q5

  • Chr Location
    4p16.3; chr4:2071958-2242164 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Radiation induced
    5
  • Spontaneous
    1
  • Targeted
    7
  • Genomic Mutations
    9 involving Poln
  • Incidental Mutations
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele exhibit reduced meiotic double-strand breaks at a meiotic recombination hot spot harboring insertion/deletion polymorphisms, but are otherwise normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045102 Ensembl Gene Model | MGI Sequence Detail 162270 C57BL/6J ±  kb
transcript ENSMUST00000042954 Ensembl | MGI Sequence Detail 2897 Not Applicable  
polypeptide ENSMUSP00000036110 Ensembl | MGI Sequence Detail 866 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    Genomic 2
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 46
    Diseases 1
    Gene Ontology 4
    Phenotypes 26
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:241704 Takata KI, et al., Analysis of DNA polymerase nu function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance. PLoS Genet. 2017 Jun;13(6):e1006818

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory