Trpm6
Gene Detail

Symbol Name ID

Trpm6 transient receptor potential cation channel, subfamily M, member 6 MGI:2675603

Synonyms

CHAK2

Feature Type

protein coding gene

Genetic Map

Chromosome 19

13.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr19:18749983-18892510 bp, + strand From Ensembl annotation of GRCm38   142528 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9767  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: transient receptor potential cation channels TRPM6/TRPM7
Gene Tree: Trpm6

Human homologs

Human Homolog		TRPM6, transient receptor potential cation channel, subfamily M, member 6
NCBI Gene ID		140803
neXtProt AC		NX_Q9BX84
Human Synonyms		CHAK2, HMGX, HOMG, HOMG1, HSH
Human Chr (Location)		9q21.13; chr9:77337411-77503010 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TRPM6

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele exhibit embryonic and postnatal lethality with exencephaly, spina bifida occulta, and abnormal brain and facial development. Mice heterozygous for a knock-out allele exhibit some premature death and decreased serum magnesium.

 

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	apical plasma membrane, brush border membrane, ...
Function	ATP binding, calcium channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (55)    Tissues (34)    Images (2)
Theiler Stages: 6, 8, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Northern blot	24
RT-PCR	31

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) cDNA(22) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000024727 (Evidence)
Entrez Gene	225997 (Evidence)
UniGene	215171
DFCI	TC1584454, TC1609620
DoTS	DT.91368764, DT.99856535
NIA Mouse Gene Index	U019269
EC	2.7.11.1
Consensus CDS Project	CCDS29691.1
International Mouse Knockout Project Status	Trpm6

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024727	Ensembl Gene Model | MGI Sequence Detail	142528	C57BL/6J
transcript	ENSMUST00000040489	Ensembl | MGI Sequence Detail	6508	Not Applicable
polypeptide	ENSMUSP00000037443	Ensembl | MGI Sequence Detail	2028	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(889 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005821	Ion transport domain
InterPro	IPR004166	MHCK/EF2 kinase
InterPro	IPR011009	Protein kinase-like domain
Protein Ontology	PR:000016702	transient receptor potential cation channel subfamily M member 6

References

(Earliest) J:78800 Ryazanov AG, et al., Alpha-kinases: a new class of protein kinases with a novel catalytic domain. Curr Biol. 1999 Jan 28;9(2):R43-5
(Latest) J:186403 Nair AV, et al., Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11324-9
All references(35)