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Trpm6 Gene Detail
Summary
  • Symbol
    Trpm6
  • Name
    transient receptor potential cation channel, subfamily M, member 6
  • Synonyms
    CHAK2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675603
    NCBI Gene: 225997
  • Gene Overview
    MyGene.info: TRPM6
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:18749983-18892510 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 13.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1308 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675603
protein coding gene Chr19:18730177-18892521 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024970
protein coding gene Chr19:16645046-16792702 (+)
A/J MGP_AJ_G0024947
protein coding gene Chr19:15698919-15845092 (+)
AKR/J MGP_AKRJ_G0024917
protein coding gene Chr19:16323295-16472564 (+)
BALB/cJ MGP_BALBcJ_G0024946
protein coding gene Chr19:15732309-15875881 (+)
C3H/HeJ MGP_C3HHeJ_G0024704
protein coding gene Chr19:16264028-16416624 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025388
protein coding gene Chr19:17230082-17384733 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022807
protein coding gene Chr19:16067320-16219583 (+)
CAST/EiJ MGP_CASTEiJ_G0024172
protein coding gene Chr19:15909041-16063029 (+)
CBA/J MGP_CBAJ_G0024682
protein coding gene Chr19:17853482-18033482 (+)
DBA/2J MGP_DBA2J_G0024814
protein coding gene Chr19:15729323-15871541 (+)
FVB/NJ MGP_FVBNJ_G0024775
protein coding gene Chr19:15645217-15783825 (+)
LP/J MGP_LPJ_G0024898
protein coding gene Chr19:16606556-16756743 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024802
protein coding gene Chr19:17741244-17898367 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025443
protein coding gene Chr19:16263746-16417718 (+)
PWK/PhJ MGP_PWKPhJ_G0023921
protein coding gene Chr19:15275560-15428409 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023726
protein coding gene Chr19:15562255-15724519 (+)
WSB/EiJ MGP_WSBEiJ_G0024240
protein coding gene Chr19:16312144-16472979 (+)



Homology
more
  • Human Ortholog
    TRPM6, transient receptor potential cation channel subfamily M member 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRPM6, transient receptor potential cation channel subfamily M member 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CHAK2, HMGX, HOMG, HOMG1, HSH
  • Links
    NCBI Gene ID: 140803
    neXtProt AC: NX_Q9BX84
    UniProt: Q9BX84

  • Chr Location
    9q21.13; chr9:74722495-74888094 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TRPM6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic and postnatal lethality with exencephaly, spina bifida occulta, and abnormal brain and facial development. Mice heterozygous for a knock-out allele exhibit some premature death and decreased serummagnesium.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024727 Ensembl Gene Model | MGI Sequence Detail 142528 C57BL/6J ±  kb
    transcript ENSMUST00000040489 Ensembl | MGI Sequence Detail 6508 Not Applicable  
    polypeptide ENSMUSP00000037443 Ensembl | MGI Sequence Detail 2028 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 23
      Primer pair 3
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:78800 Ryazanov AG, et al., Alpha-kinases: a new class of protein kinases with a novel catalytic domain. Curr Biol. 1999 Jan 28;9(2):R43-5
    • Latest
      J:239386 Chubanov V, et al., Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife. 2016 Dec 19;5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory