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Trpm6 Gene Detail
Summary
  • Symbol
    Trpm6
  • Name
    transient receptor potential cation channel, subfamily M, member 6
  • Synonyms
    CHAK2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675603
    NCBI Gene: 225997
  • Gene Overview
    MyGene.info: TRPM6
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:18749983-18892510 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      142528 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 13.21 cM
  • Mapping Data
    1 experiment
Homology
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  • Human Ortholog
    TRPM6, transient receptor potential cation channel subfamily M member 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TRPM6, transient receptor potential cation channel subfamily M member 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHAK2, HMGX, HOMG, HOMG1, HSH
  • Links
    NCBI Gene ID: 140803
    neXtProt AC: NX_Q9BX84
    UniProt: Q9BX84

  • Chr Location
    9q21.13; chr9:74722495-74888094 (-)  GRCh38.p7

Human Diseases
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  • Diseases
    1 with human TRPM6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic and postnatal lethality with exencephaly, spina bifida occulta, and abnormal brain and facial development. Mice heterozygous for a knock-out allele exhibit some premature death and decreased serummagnesium.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024727 Ensembl Gene Model | MGI Sequence Detail 142528 C57BL/6J ±  kb
    transcript ENSMUST00000040489 Ensembl | MGI Sequence Detail 6508 Not Applicable  
    polypeptide ENSMUSP00000037443 Ensembl | MGI Sequence Detail 2028 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1308 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 23
      Primer pair 3
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:78800 Ryazanov AG, et al., Alpha-kinases: a new class of protein kinases with a novel catalytic domain. Curr Biol. 1999 Jan 28;9(2):R43-5
    • Latest
      J:239386 Chubanov V, et al., Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife. 2016 Dec 19;5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory