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Trpm6
Gene Detail
Symbol

Name
ID
Trpm6
transient receptor potential cation channel, subfamily M, member 6
MGI:2675603
Synonyms
CHAK2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
13.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:18749983-18892510 bp, + strand
From Ensembl annotation of GRCm38

  142528 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9767  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TRPM6
Protein SuperFamily: transient receptor potential cation channels TRPM6/TRPM7
Gene Tree: Trpm6

Human
homologs
TRPM6, transient receptor potential cation channel, subfamily M, member 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 140803
neXtProt AC: NX_Q9BX84

Human Synonyms: CHAK2, HMGX, HOMG, HOMG1, HSH

Human Chr (Location): 9q21.13; chr9:74722495-74888094 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TRPM6

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic and postnatal lethality with exencephaly, spina bifida occulta, and abnormal brain and facial development. Mice heterozygous for a knock-out allele exhibit some premature death and decreased serum magnesium.
 
Interactions
Trpm6 interacts with 152 markers (Mir19b-1, Mir19b-2, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component apical plasma membrane, brush border membrane, ...
Function ATP binding, calcium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (52)    Tissues (34)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 21
RT-PCR 31
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase trpm6 ; ZFIN trpm6    NEW 
Molecular
reagents
All nucleic(26) cDNA(22) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000024727 (Evidence)
Entrez Gene 225997 (Evidence)
UniGene 215171
DFCI TC1584454, TC1609620
DoTS DT.91368764, DT.99856535
NIA Mouse Gene Index U019269
EC 2.7.11.1
Consensus CDS Project CCDS29691.1
International Mouse Phenotyping Consortium Status Trpm6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024727 Ensembl Gene Model | MGI Sequence Detail 142528 C57BL/6J ±  kb
transcript ENSMUST00000040489 Ensembl | MGI Sequence Detail 6508 Not Applicable 
polypeptide ENSMUSP00000037443 Ensembl | MGI Sequence Detail 2028 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(1157 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005821 Ion transport domain
InterPro IPR004166 MHCK/EF2 kinase
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000016702 transient receptor potential cation channel subfamily M member 6
References
(Earliest) J:78800 Ryazanov AG, et al., Alpha-kinases: a new class of protein kinases with a novel catalytic domain. Curr Biol. 1999 Jan 28;9(2):R43-5
(Latest) J:186403 Nair AV, et al., Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11324-9
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory