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Nanos3 Gene Detail
Summary
  • Symbol
    Nanos3
  • Name
    nanos C2HC-type zinc finger 3
  • Synonyms
    nos3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675387
    NCBI Gene: 244551
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:84173731-84185217 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11487 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 40.45 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NANOS3, nanos C2HC-type zinc finger 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NANOS3, nanos C2HC-type zinc finger 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NANOS1L, NOS3, ZC2HC12C
  • Links
    NCBI Gene ID: 342977
    neXtProt AC: NX_P60323
    UniProt: P60323

  • Chr Location
    19p13.12; chr19:13876383-13880762 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus results in both male and female infertility. Both male and female gonads are reduced in size and are devoid of germ cells, putatively due to impaired maintainence of primordial germ cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000061277 VEGA Gene Model | MGI Sequence Detail 11487 C57BL/6J ±  kb
    transcript OTTMUST00000149553 VEGA | MGI Sequence Detail 730 Not Applicable  
    polypeptide OTTMUSP00000077589 VEGA | MGI Sequence Detail 178 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      115 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 6
      Primer pair 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 10
      Gene Ontology 8
      Phenotypes 47
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
    • Latest
      J:249718 Zhou Z, et al., NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes. Nat Commun. 2017 Jun 06;8(None):15662

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory