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Tnfrsf14 Gene Detail
Summary
  • Symbol
    Tnfrsf14
  • Name
    tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
  • Synonyms
    Atar, HveA, Hvem
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675303
    NCBI Gene: 230979
  • Gene Overview
    MyGene.info: TNFRSF14
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:154921933-154928563 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 85.81 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675303
protein coding gene Chr4:154921442-154928620 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029202
protein coding gene Chr4:159207141-159213498 (-)
A/J MGP_AJ_G0029167
protein coding gene Chr4:152525561-152531957 (-)
AKR/J MGP_AKRJ_G0029115
protein coding gene Chr4:156683741-156690098 (-)
BALB/cJ MGP_BALBcJ_G0029183
protein coding gene Chr4:152994216-153000577 (-)
C3H/HeJ MGP_C3HHeJ_G0028904
protein coding gene Chr4:157220903-157227259 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029632
protein coding gene Chr4:164896443-164902796 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026878
protein coding gene Chr4:144824107-144834329 (-)
CAST/EiJ MGP_CASTEiJ_G0028317
protein coding gene Chr4:154643942-154653918 (-)
CBA/J MGP_CBAJ_G0028866
protein coding gene Chr4:169836653-169843003 (-)
DBA/2J MGP_DBA2J_G0029015
protein coding gene Chr4:152550596-152556986 (-)
FVB/NJ MGP_FVBNJ_G0028979
protein coding gene Chr4:151773840-151780192 (-)
LP/J MGP_LPJ_G0029105
protein coding gene Chr4:159132785-159139142 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029006
protein coding gene Chr4:172717725-172724076 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029664
protein coding gene Chr4:157275707-157282060 (-)
PWK/PhJ MGP_PWKPhJ_G0028037
protein coding gene Chr4:148670640-148679013 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027871
protein coding gene Chr4:151556485-151564673 (-)
WSB/EiJ MGP_WSBEiJ_G0028397
protein coding gene Chr4:157443381-157449735 (-)



Homology
more
  • Human Ortholog
    TNFRSF14, TNF receptor superfamily member 14
  • Vertebrate Orthologs
    21
  • Human Ortholog
    TNFRSF14, TNF receptor superfamily member 14
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATAR, CD270, HVEA, HVEM, LIGHTR, TR2
  • Links
    NCBI Gene ID: 8764
    neXtProt AC: NX_Q92956
    UniProt: Q92956

  • Chr Location
    1p36.32; chr1:2555767-2565622 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 5 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele are less susceptible to induced colitis. Homozygotes for a second null allele exhibit enhanced responses to various T cell stimuli and are more susceptible to developing autoimmune diseases. Homozygotes for a third null allele show reduced length of allograft survival.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042333 Ensembl Gene Model | MGI Sequence Detail 6631 C57BL/6J ±  kb
transcript ENSMUST00000219534 Ensembl | MGI Sequence Detail 1173 Not Applicable  
polypeptide ENSMUSP00000151575 Ensembl | MGI Sequence Detail 276 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • InterPro Domains
    IPR001368 TNFR/NGFR cysteine-rich region
    IPR034031 Tumor necrosis factor receptor 14/UL144, N-terminal
    IPR022332 Tumour necrosis factor receptor 14
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 72
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 42
  • Earliest
    J:40487 Hsu H, et al., ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. J Biol Chem. 1997 May 23;272(21):13471-4
  • Latest
    J:266163 Seo GY, et al., LIGHT-HVEM Signaling in Innate Lymphoid Cell Subsets Protects Against Enteric Bacterial Infection. Cell Host Microbe. 2018 Aug 8;24(2):249-260.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory