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Tnfrsf14
Gene Detail
Symbol

Name
ID
Tnfrsf14
tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
MGI:2675303
Synonyms
Atar, HveA, Hvem
Feature Type
protein coding gene
Genetic Map
Chromosome 4
85.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:154922210-154928563 bp, - strand
From VEGA annotation of GRCm38

  6354 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2833  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 14 zebrafish

Protein SuperFamily: tumor necrosis factor receptor superfamily member, CD40 type
Gene Tree: Tnfrsf14

Human
homologs
Human Homolog TNFRSF14, tumor necrosis factor receptor superfamily, member 14
NCBI Gene ID 8764
neXtProt AC  NX_Q92956
Human Synonyms  ATAR, CD270, HVEA, HVEM, LIGHTR, TR2
Human Chr (Location)  1p36.32; chr1:2556366-2563829 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Genomic Mutations involving Tnfrsf14 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele are less susceptible to induced colitis. Homozygotes for a second null allele exhibit enhanced responses to various T cell stimuli and are more susceptible to developing autoimmune diseases. Homozygotes for a third null allele show reduced length of allograft survival.
 
Interactions
Tnfrsf14 interacts with 3 markers (Mir466q, Mir532, Mir654)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (21)    Tissues (1)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000010461 (Evidence)
Ensembl Gene ModelENSMUSG00000042333 (Evidence)
Entrez Gene230979 (Evidence)
UniGene215147
DFCITC1630180, TC1589618
DoTSDT.91412256
NIA Mouse Gene IndexU025864
Consensus CDS ProjectCCDS19017.1
International Mouse Knockout Project StatusTnfrsf14
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010461 VEGA Gene Model | MGI Sequence Detail 6354 C57BL/6J ±  kb
transcript OTTMUST00000025077 VEGA | MGI Sequence Detail 893 Not Applicable 
polypeptide OTTMUSP00000011488 VEGA | MGI Sequence Detail 275 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(10) UniProt(10)
Polymorphisms
SNPs within 2kb(98 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR022332 Tumour necrosis factor receptor 14
Protein Ontology PR:000016481 tumor necrosis factor receptor superfamily member 14
References
(Earliest) J:85468 Ware CF, The TNF Superfamily. Cytokine Growth Factor Rev. 2003 Jun;14(3-4):181-4
(Latest) J:205267 Allen SJ, et al., Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency. J Virol. 2014 Feb;88(4):1961-71
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory