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Rims4 Gene Detail
Summary
  • Symbol
    Rims4
  • Name
    regulating synaptic membrane exocytosis 4
  • Synonyms
    Rim4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2674366
    NCBI Gene: 241770
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:163701671-163760603 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 84.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1771 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2674366
 protein coding gene Chr2:163701671-163760893 (-)
129S1/SvImJ ENSMUSG00200015770
 protein coding gene Chr2:160579435-160637767 (-)
A/J ENSMUSG00195020284
 protein coding gene Chr2:160921000-160979615 (-)
AKR/J ENSMUSG00220013767
 protein coding gene Chr2:160248488-160306778 (-)
BALB/cJ ENSMUSG00180046967
 protein coding gene Chr2:160374736-160433347 (-)
C3H/HeJ ENSMUSG00175049155
 protein coding gene Chr2:161124480-161183080 (-)
C57BL/6NJ ENSMUSG00215031645
 protein coding gene Chr2:160571982-160630927 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024625
 protein coding gene Chr2:155692274-155750048 (-)
CAST/EiJ ENSTCUG00005043639
 protein coding gene Chr2:159484955-159543846 (-)
CBA/J ENSMUSG00210015489
 protein coding gene Chr2:161055513-161114123 (-)
DBA/2J ENSMUSG00185045917
 protein coding gene Chr2:160791819-160850074 (-)
FVB/NJ ENSMUSG00205036198
 protein coding gene Chr2:159814732-159873278 (-)
JF1/MsJ ENSUMUG00000008549
 protein coding gene Chr2:160428765-160487587 (-)
LP/J ENSMUSG00230042779
 protein coding gene Chr2:162349041-162407364 (-)
NOD/ShiLtJ ENSMUSG00190034697
 protein coding gene Chr2:160453983-160512950 (-)
NZO/HlLtJ ENSMUSG00225052499
 protein coding gene Chr2:170354179-170412439 (-)
PWK/PhJ ENSLUMG00010041734
 protein coding gene Chr2:160334785-160393503 (-)
SPRET/EiJ ENSMSPG00010027371
 protein coding gene Chr2:163105755-163163481 (-)
WSB/EiJ ENSIUOG00005040355
 protein coding gene Chr2:160183833-160242339 (-)



Homology
more
  • Human Ortholog
    RIMS4, regulating synaptic membrane exocytosis 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RIMS4, regulating synaptic membrane exocytosis 4
  • Synonyms
    C20orf190, RIM 4, RIM-4, RIM4, RIM4-gamma, RIM4gamma
  • Links
    NCBI Gene ID: 140730
    UniProt: Q9H426

  • Chr Location
    20q13.12; chr20:44751808-44810546 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induec allele exhibit reduced body weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    640
  • Tissues
    29
  • cDNA Data
    8
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035226 Ensembl Gene Model | MGI Sequence Detail 58933 C57BL/6J ±  kb
    transcript ENSMUST00000044734 Ensembl | MGI Sequence Detail 4962 Not Applicable  
    polypeptide ENSMUSP00000045637 Ensembl | MGI Sequence Detail 269 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 5
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:332132 Cattaneo P, et al., DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal. Nat Commun. 2022 Dec 2;13(1):7444
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory