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Sspo Gene Detail
Summary
  • Symbol
    Sspo
  • Name
    SCO-spondin
  • Synonyms
    C79529, Scospondin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2674311
    NCBI Gene: 243369
  • Gene Overview
    MyGene.info: SSPO
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:48448229-48501250 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 23.42 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    336 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2674311
protein coding gene Chr6:48446230-48501262 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030694
protein coding gene Chr6:47386077-47444084 (+)
A/J MGP_AJ_G0030665
protein coding gene Chr6:45238589-45293862 (+)
AKR/J MGP_AKRJ_G0030590
protein coding gene Chr6:46833535-46888235 (+)
BALB/cJ MGP_BALBcJ_G0030675
protein coding gene Chr6:45573446-45626574 (+)
C3H/HeJ MGP_C3HHeJ_G0030388
protein coding gene Chr6:46834836-46892244 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031130
protein coding gene Chr6:48507221-48565412 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028336
protein coding gene Chr6:42874429-42927599 (+)
CAST/EiJ MGP_CASTEiJ_G0029792
protein coding gene Chr6:46555269-46609700 (+)
CBA/J MGP_CBAJ_G0030363
protein coding gene Chr6:50521014-50579549 (+)
DBA/2J MGP_DBA2J_G0030512
protein coding gene Chr6:45157714-45211510 (+)
FVB/NJ MGP_FVBNJ_G0030464
protein coding gene Chr6:44787583-44842632 (+)
LP/J MGP_LPJ_G0030597
protein coding gene Chr6:47361768-47414692 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030498
protein coding gene Chr6:53341306-53401740 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031159
protein coding gene Chr6:46692100-46745692 (+)
PWK/PhJ MGP_PWKPhJ_G0029504
protein coding gene Chr6:44686833-44740896 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029340
protein coding gene Chr6:46043936-46097085 (+)
WSB/EiJ MGP_WSBEiJ_G0029869
protein coding gene Chr6:46691230-46748823 (+)



Homology
more
  • Human Ortholog
    SSPO, SCO-spondin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SSPO, SCO-spondin
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23145
    neXtProt AC: NX_A2VEC9
    UniProt: A2VEC9

  • Chr Location
    7q36.1; chr7:149776042-149833965 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 45453
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SSPO
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029797 Ensembl Gene Model | MGI Sequence Detail 53022 C57BL/6J ±  kb
transcript ENSMUST00000169350 Ensembl | MGI Sequence Detail 15571 Not Applicable  
polypeptide ENSMUSP00000131401 Ensembl | MGI Sequence Detail 5144 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR000421 Coagulation factor 5/8 C-terminal domain
    IPR006207 Cystine knot, C-terminal
    IPR008979 Galactose-binding-like domain superfamily
    IPR036055 LDL receptor-like superfamily
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR008037 Pacifastin domain
    IPR030119 SCO-spondin
    IPR036084 Serine protease inhibitor-like superfamily
    IPR000884 Thrombospondin type-1 (TSP1) repeat
    IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    IPR002919 Trypsin Inhibitor-like, cysteine rich domain
    IPR014853 Uncharacterised domain, cysteine-rich
    IPR001846 von Willebrand factor, type D domain
    IPR001007 VWFC domain
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141753
References
more
  • Summaries
    All 29
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory