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Sspo Gene Detail
Summary
  • Symbol
    Sspo
  • Name
    SCO-spondin
  • Synonyms
    C79529, Scospondin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2674311
    NCBI Gene: 243369
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:48425163-48478184 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 23.42 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1311 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2674311
 protein coding gene Chr6:48423164-48478196 (+)
129S1/SvImJ ENSMUSG00200004829
 protein coding gene Chr6:45330778-45383800 (+)
A/J ENSMUSG00195006194
 protein coding gene Chr6:45106497-45159664 (+)
AKR/J ENSMUSG00220003128
 protein coding gene Chr6:44815847-44868986 (+)
BALB/cJ ENSMUSG00180019531
 protein coding gene Chr6:45419257-45472396 (+)
C3H/HeJ ENSMUSG00175015174
 protein coding gene Chr6:45180897-45234068 (+)
C57BL/6NJ ENSMUSG00215005763
 protein coding gene Chr6:45375804-45428829 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028336
 protein coding gene Chr6:42874429-42927599 (+)
CAST/EiJ ENSTCUG00005004420
 protein coding gene Chr6:44697200-44750522 (+)
CBA/J ENSMUSG00210017816
 protein coding gene Chr6:45225748-45278906 (+)
DBA/2J ENSMUSG00185013417
 protein coding gene Chr6:45807437-45860596 (+)
FVB/NJ ENSMUSG00205018727
 protein coding gene Chr6:45471883-45525048 (+)
JF1/MsJ ENSUMUG00000007024
 protein coding gene Chr6:45168545-45221606 (+)
LP/J ENSMUSG00230019351
 protein coding gene Chr6:46827909-46880926 (+)
NOD/ShiLtJ ENSMUSG00190032492
 protein coding gene Chr6:45145746-45198904 (+)
NZO/HlLtJ ENSMUSG00225016581
 protein coding gene Chr6:48864435-48917455 (+)
PWK/PhJ ENSLUMG00010018764
 protein coding gene Chr6:44802713-44855841 (+)
SPRET/EiJ ENSMSPG00010008949
 protein coding gene Chr6:45428069-45481286 (+)
WSB/EiJ ENSIUOG00005026540
 protein coding gene Chr6:45439936-45493046 (+)



Homology
more
  • Human Ortholog
    SSPOP, SCO-spondin, pseudogene
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SSPOP, SCO-spondin, pseudogene
  • Synonyms
    SSPO
  • Links
    NCBI Gene ID: 23145
    UniProt: A2VEC9

  • Chr Location
    7q36.1; chr7:149776042-149833965 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display absence of Reissner's fiber and decreased brain ventricle volume.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    624
  • Tissues
    15
  • cDNA Data
    9
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029797 Ensembl Gene Model | MGI Sequence Detail 53022 C57BL/6J ±  kb
    transcript ENSMUST00000169350 Ensembl | MGI Sequence Detail 15571 Not Applicable  
    polypeptide ENSMUSP00000131401 Ensembl | MGI Sequence Detail 5144 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000015658 SCO-spondin
      (term hierarchy)
    • InterPro Domains
      IPR000421 Coagulation factor 5/8, C-terminal domain
      IPR006207 Cystine knot, C-terminal
      IPR008979 Galactose-binding-like domain superfamily
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR050780 Mucin/von Willebrand/Thrombospondin superfamily
      IPR052065 Properdin-like
      IPR036084 Serine protease inhibitor-like superfamily
      IPR036383 Thrombospondin type-1 repeat superfamily
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR002919 Trypsin Inhibitor-like, cysteine rich domain
      IPR001846 von Willebrand factor, type D domain
      IPR001007 VWFC domain
      IPR014853 VWF/SSPO/Zonadhesin-like, cysteine-rich domain
    • GlyGen
      Q8CG65 46 sites, 5 N-linked glycans (6 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141753
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:374541 Zhang T, et al., The subcommissural organ regulates brain development via secreted peptides. Nat Neurosci. 2024 Jun;27(6):1103-1115
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory