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Arhgap33 Gene Detail
Summary
  • Symbol
    Arhgap33
  • Name
    Rho GTPase activating protein 33
  • Synonyms
    NOMA-GAP, Snx26, Tcgap
  • Feature Type
    protein coding gene
  • IDs
    MGI:2673998
    NCBI Gene: 233071
  • Gene Overview
    MyGene.info: ARHGAP33
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30522226-30535060 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 18.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    169 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2673998
protein coding gene Chr7:30522225-30535093 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032024
protein coding gene Chr7:29520126-29532772 (-)
A/J MGP_AJ_G0032001
protein coding gene Chr7:28727384-28739268 (-)
AKR/J MGP_AKRJ_G0031934
protein coding gene Chr7:29459172-29471035 (-)
BALB/cJ MGP_BALBcJ_G0032008
protein coding gene Chr7:28905238-28917110 (-)
C3H/HeJ MGP_C3HHeJ_G0031727
protein coding gene Chr7:29914359-29927164 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032474
protein coding gene Chr7:30482109-30494860 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029524
protein coding gene Chr7:29755835-29768287 (-)
CAST/EiJ MGP_CASTEiJ_G0031061
protein coding gene Chr7:23165995-23181665 (-)
CBA/J MGP_CBAJ_G0031693
protein coding gene Chr7:31930058-31942881 (-)
DBA/2J MGP_DBA2J_G0031845
protein coding gene Chr7:28456721-28469536 (-)
FVB/NJ MGP_FVBNJ_G0031802
protein coding gene Chr7:28584906-28597630 (-)
LP/J MGP_LPJ_G0031926
protein coding gene Chr7:29835179-29847978 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031838
protein coding gene Chr7:31180250-31192997 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032502
protein coding gene Chr7:28966179-28978147 (-)
PWK/PhJ MGP_PWKPhJ_G0030787
protein coding gene Chr7:23488241-23501144 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030620
protein coding gene Chr7:19971134-19987627 (-)
WSB/EiJ MGP_WSBEiJ_G0031171
protein coding gene Chr7:29353455-29366191 (-)



Homology
more
  • Human Ortholog
    ARHGAP33, Rho GTPase activating protein 33
  • Vertebrate Orthologs
    6
  • Human Ortholog
    ARHGAP33, Rho GTPase activating protein 33
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NOMA-GAP, SNX26, TCGAP
  • Links
    NCBI Gene ID: 115703
    neXtProt AC: NX_O14559
    UniProt: O14559

  • Chr Location
    19q13.12; chr19:35775515-35788822 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display region specific thinning of the cerebral cortex with reduced dendritic complexity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036882 Ensembl Gene Model | MGI Sequence Detail 12835 C57BL/6J ±  kb
    transcript ENSMUST00000207860 Ensembl | MGI Sequence Detail 4396 Not Applicable  
    polypeptide ENSMUSP00000146602 Ensembl | MGI Sequence Detail 1305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 111
      cDNA 111

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2142229
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:83822 Chiang SH, et al., TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J. 2003 Jun 1;22(11):2679-91
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory