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Arhgap33
Gene Detail
 Symbol
Name
ID
Arhgap33
Rho GTPase activating protein 33
MGI:2673998
Synonyms NOMA-GAP, Snx26, Tcgap
Feature Type protein coding gene
Genetic Map
Chromosome 7
18.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:30522226-30534180 bp, - strand
From Ensembl annotation of GRCm38

  11955 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:76448  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Arhgap33

Human
homologs
Human Homolog ARHGAP33, Rho GTPase activating protein 33
NCBI Gene ID 115703
neXtProt AC  NX_O14559
Human Synonyms  NOMA-GAP, SNX26, TCGAP
Human Chr (Location)  19q13.12; chr19:35775515-35788822 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display region specific thinning of the cerebral cortex with reduced dendritic complexity.
 
Interactions
Arhgap33 interacts with 86 markers (Mir7-2, Mir7b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process positive regulation of Rac GTPase activity, protein transport, ...
Component cytoplasm, intracellular, ...
Function GTPase activator activity, phosphatidylinositol binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (39)    Tissues (15)    Images (17)
Theiler Stages: 18, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 26
Western blot 13
cDNA source data(110)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(110) cDNA(110)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000036882 (Evidence)
Entrez Gene233071 (Evidence)
UniGene190704
DFCITC1578270, TC1607731
DoTSDT.101378795, DT.101378796, DT.99848874, DT.99848878
NIA Mouse Gene IndexU028386
Consensus CDS ProjectCCDS21095.1
International Mouse Knockout Project StatusArhgap33
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036882 Ensembl Gene Model | MGI Sequence Detail 11955 C57BL/6J ±  kb
transcript ENSMUST00000044338 Ensembl | MGI Sequence Detail 4280 Not Applicable 
polypeptide ENSMUSP00000038412 Ensembl | MGI Sequence Detail 1305 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(18) UniProt(2)
Polymorphisms SNPs within 2kb(182 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001683 Phox homologous domain
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000015375 rho GTPase-activating protein 33
References (Earliest) J:83822 Chiang SH, et al., TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J. 2003 Jun 1;22(11):2679-91
(Latest) J:185948 Rosario M, et al., Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin. Genes Dev. 2012 Aug 1;26(15):1743-57
All references(27)
Other
accession IDs
MGI:2142229

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory