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Frat2
Gene Detail
Symbol

Name
ID
Frat2
frequently rearranged in advanced T cell lymphomas 2
MGI:2673967
Synonyms
MGC:37615
Feature Type
protein coding gene
Genetic Map
Chromosome 19
35.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:41845978-41848132 bp, - strand
From Ensembl annotation of GRCm38

  2155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8095  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: FRAT2
Gene Tree: Frat2

Human
homologs
FRAT2, frequently rearranged in advanced T-cell lymphomas 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23401
neXtProt AC: NX_O75474

Human Chr (Location): 10q24.1; chr10:97332497-97334701 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from CvDC )
 
Homozygous mice are healthy and fertile with no obvious abnormalities.
 
Interactions
Frat2 interacts with 147 markers (Mir7-1, Mir10a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process Wnt signaling pathway
Component cellular_component
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (191)    Tissues (187)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 179
In situ reporter (knock in) 8
RT-PCR 4
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(19) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000047604 (Evidence)
Entrez Gene 212398 (Evidence)
UniGene 222723
DFCI TC1583512
DoTS DT.528043
NIA Mouse Gene Index U039040
Consensus CDS Project CCDS29813.1
International Mouse Phenotyping Consortium Status Frat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047604 Ensembl Gene Model | MGI Sequence Detail 2155 C57BL/6J ±  kb
transcript ENSMUST00000059231 Ensembl | MGI Sequence Detail 2155 Not Applicable 
polypeptide ENSMUSP00000052788 Ensembl | MGI Sequence Detail 231 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008014 Glycogen synthase kinase-3 binding protein
Protein Ontology PR:000007655 GSK-3-binding protein FRAT2
References
(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:192364 Walf-Vorderwulbecke V, et al., Frat2 mediates the oncogenic activation of Rac by MLL fusions. Blood. 2012 Dec 6;120(24):4819-28
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory