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Frat2
Gene Detail
 Symbol
Name
ID
Frat2
frequently rearranged in advanced T cell lymphomas 2
MGI:2673967
Synonyms MGC:37615
Feature Type protein coding gene
Genetic Map
Chromosome 19
35.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:41845978-41848132 bp, - strand
From Ensembl annotation of GRCm38

  2155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8095  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Frat2

Human
homologs
Human Homolog FRAT2, frequently rearranged in advanced T-cell lymphomas 2
NCBI Gene ID 23401
neXtProt AC  NX_O75474
Human Chr (Location)  10q24.1; chr10:97332497-97334701 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Homozygous mice are healthy and fertile with no obvious abnormalities.
 
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process Wnt signaling pathway
Component cellular_component
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (191)    Tissues (187)    Images (17)
Theiler Stages: 11, 13, 17, 22, 23, 26, 28
Assay TypeResults
RNA in situ 179
In situ reporter (knock in) 8
RT-PCR 4
cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(22) cDNA(19) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000047604 (Evidence)
Entrez Gene212398 (Evidence)
UniGene222723
DFCITC1583512
DoTSDT.528043
NIA Mouse Gene IndexU039040
Consensus CDS ProjectCCDS29813.1
International Mouse Knockout Project StatusFrat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047604 Ensembl Gene Model | MGI Sequence Detail 2155 C57BL/6J ±  kb
transcript ENSMUST00000059231 Ensembl | MGI Sequence Detail 2155 Not Applicable 
polypeptide ENSMUSP00000052788 Ensembl | MGI Sequence Detail 231 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(3 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008014 Glycogen synthase kinase-3 binding protein
Protein Ontology PR:000007655 GSK-3-binding protein FRAT2
References (Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:192364 Walf-Vorderwulbecke V, et al., Frat2 mediates the oncogenic activation of Rac by MLL fusions. Blood. 2012 Dec 6;120(24):4819-28
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory