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Tnfsf18 Gene Detail
Summary
  • Symbol
    Tnfsf18
  • Name
    tumor necrosis factor (ligand) superfamily, member 18
  • Synonyms
    Gitrl, GITR ligand
  • Feature Type
    protein coding gene
  • IDs
    MGI:2673064
    NCBI Gene: 240873
  • Gene Overview
    MyGene.info: TNFSF18
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:161494657-161505290 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 69.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2673064
protein coding gene Chr1:161494655-161505290 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016653
protein coding gene Chr1:166777188-166789331 (+)
A/J MGP_AJ_G0016634
protein coding gene Chr1:159996316-160006936 (+)
AKR/J MGP_AKRJ_G0016600
protein coding gene Chr1:164858669-164869295 (+)
BALB/cJ MGP_BALBcJ_G0016595
protein coding gene Chr1:160541843-160552473 (+)
C3H/HeJ MGP_C3HHeJ_G0016419
protein coding gene Chr1:165076022-165086654 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017056
protein coding gene Chr1:172423416-172434051 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014765
protein coding gene Chr1:152102252-152113471 (+)
CAST/EiJ MGP_CASTEiJ_G0015999
protein coding gene Chr1:164694994-164705600 (+)
CBA/J MGP_CBAJ_G0016394
protein coding gene Chr1:178549018-178559652 (+)
DBA/2J MGP_DBA2J_G0016500
protein coding gene Chr1:158966946-158977384 (+)
FVB/NJ MGP_FVBNJ_G0016498
protein coding gene Chr1:157371504-157382143 (+)
LP/J MGP_LPJ_G0016571
protein coding gene Chr1:167878453-167889087 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016523
protein coding gene Chr1:186080428-186094578 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017092
protein coding gene Chr1:164682378-164693012 (+)
PWK/PhJ MGP_PWKPhJ_G0015785
protein coding gene Chr1:158132629-158143305 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015572
protein coding gene Chr1:163576655-163587295 (+)
WSB/EiJ MGP_WSBEiJ_G0016061
protein coding gene Chr1:164873606-164884228 (+)



Homology
more
  • Human Ortholog
    TNFSF18, TNF superfamily member 18
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TNFSF18, TNF superfamily member 18
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AITRL, GITRL, hGITRL, TL6, TNLG2A
  • Links
    NCBI Gene ID: 8995
    neXtProt AC: NX_Q9UNG2
    UniProt: Q9UNG2

  • Chr Location
    1q25.1; chr1:173041220-173050963 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 240873 NCBI Gene Model | MGI Sequence Detail 10634 C57BL/6J ±  kb
transcript NM_183391 RefSeq | MGI Sequence Detail 2064 Not Specified  
polypeptide Q7TS55 UniProt | EBI | MGI Sequence Detail 173 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 47
    Gene Ontology 12
    Phenotypes 8
  • Earliest
    J:86980 Tone M, et al., Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15059-64
  • Latest
    J:259399 Kobayashi Y, et al., Macrophage-T cell interactions mediate neuropathic pain through the glucocorticoid-induced tumor necrosis factor ligand system. J Biol Chem. 2015 May 15;290(20):12603-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory