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Defb37 Gene Detail
Summary
  • Symbol
    Defb37
  • Name
    defensin beta 37
  • Feature Type
    protein coding gene
  • IDs
    MGI:2672966
    NCBI Gene: 353320
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:19036266-19041072 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2672966
 protein coding gene Chr8:19036249-19041072 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033408
 protein coding gene Chr8:16474908-16479736 (-)
A/J MGP_AJ_G0033389
 protein coding gene Chr8:15903512-15908331 (-)
AKR/J MGP_AKRJ_G0033319
 protein coding gene Chr8:16361633-16366457 (-)
BALB/cJ MGP_BALBcJ_G0033389
 protein coding gene Chr8:16014634-16019450 (-)
C3H/HeJ MGP_C3HHeJ_G0033102
 protein coding gene Chr8:16562488-16567308 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033901
 protein coding gene Chr8:17000810-17005632 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030867
 protein coding gene Chr8:15198379-15203181 (-)
CAST/EiJ MGP_CASTEiJ_G0032424
 protein coding gene Chr8:16417067-16421900 (-)
CBA/J MGP_CBAJ_G0033075
 protein coding gene Chr8:17756066-17760890 (-)
DBA/2J MGP_DBA2J_G0033229
 protein coding gene Chr8:15864329-15869152 (-)
FVB/NJ MGP_FVBNJ_G0033177
 protein coding gene Chr8:15861221-15866047 (-)
LP/J MGP_LPJ_G0033322
 protein coding gene Chr8:16501390-16506199 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033214
 protein coding gene Chr8:17888698-17894370 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033918
 protein coding gene Chr8:16392741-16397563 (-)
PWK/PhJ MGP_PWKPhJ_G0032137
 protein coding gene Chr8:15880141-15884966 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031978
 protein coding gene Chr8:16313603-16318460 (-)
WSB/EiJ MGP_WSBEiJ_G0032540
 protein coding gene Chr8:16472819-16477632 (-)



Homology
more
  • Human Ortholog
    DEFB1, defensin beta 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB1, defensin beta 1
  • Synonyms
    BD1, DEFB-1, DEFB101, HBD1
  • Links
    NCBI Gene ID: 1672
    neXtProt AC: NX_P60022
    UniProt: P60022

  • Chr Location
    8p23.1; chr8:6870592-6877936 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human DEFB1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 353320 NCBI Gene Model | MGI Sequence Detail 4807 C57BL/6J ±  kb
transcript NM_181683 RefSeq | MGI Sequence Detail 336 C57BL/6  
polypeptide Q7TMD2 UniProt | EBI | MGI Sequence Detail 62 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 14
    Gene Ontology 2
    Phenotypes 2
  • Earliest
    J:93238 Zaballos A, et al., Identification on mouse chromosome 8 of new beta-defensin genes with regionally specific expression in the male reproductive organ. J Biol Chem. 2004 Apr 26;279(13):12421-6
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory