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Slfn8 Gene Detail
Summary
  • Symbol
    Slfn8
  • Name
    schlafen 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2672859
    NCBI Gene: 276950
  • Alliance
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:82892984-82911636 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 50.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    391 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2672859
protein coding gene Chr11:82892984-82911636 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0018804
protein coding gene Chr11:81078519-81104477 (-)
AKR/J MGP_AKRJ_G0018775
protein coding gene Chr11:83500607-83518589 (-)
BALB/cJ MGP_BALBcJ_G0018778
protein coding gene Chr11:81454058-81492310 (-)
C3H/HeJ MGP_C3HHeJ_G0018592
protein coding gene Chr11:83562222-83575168 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019230
protein coding gene Chr11:86794627-86852053 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016864
protein coding gene Chr11:78009527-78017920 (-)
CAST/EiJ MGP_CASTEiJ_G0018146
protein coding gene Chr11:84184876-84194131 (-)
CBA/J MGP_CBAJ_G0018563
protein coding gene Chr11:90614308-90625718 (-)
DBA/2J MGP_DBA2J_G0018671
protein coding gene Chr11:80648713-80700365 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0018741
protein coding gene Chr11:84809881-84841558 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018687
protein coding gene Chr11:90745736-90822252 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0017917
protein coding gene Chr11:81431611-81476352 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017708
protein coding gene Chr11:83357362-83364783 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SLFN11, schlafen family member 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLFN11, schlafen family member 11
  • Synonyms
    SLFN8/9
  • Links
    NCBI Gene ID: 91607
    neXtProt AC: NX_Q7Z7L1
    UniProt: Q7Z7L1

  • Chr Location
    17q12; chr17:35350305-35373914 (-)  GRCh38.p7

  • Human Ortholog
    SLFN13, schlafen family member 13
  • Synonyms
    hSLFN13, SLFN10
  • Links
    NCBI Gene ID: 146857
    neXtProt AC: NX_Q68D06
    UniProt: Q68D06

  • Chr Location
    17q12; chr17:35435096-35448837 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased susceptibility to experimental autoimmune encephalomyelitis (EAE) and reduced pro-inflammatory cytokine levels after EAE induction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 276950 NCBI Gene Model | MGI Sequence Detail 18653 C57BL/6J ±  kb
transcript NM_181545 RefSeq | MGI Sequence Detail 4011 C57BL/6  
polypeptide B1ARD8 UniProt | EBI | MGI Sequence Detail 910 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • EC
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR007421 Schlafen, AlbA_2 domain
    IPR038461 Schlafen, AlbA_2 domain superfamily
    IPR029684 Schlafen family
    IPR018647 Schlafen group 3-like, DNA/RNA helicase domain
    IPR027785 UvrD-like helicase C-terminal domain
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:283188 Yang JY, et al., Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control. Nat Commun. 2018 Mar 21;9(1):1165

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/28/2022
MGI 6.20
The Jackson Laboratory