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Tspear
Gene Detail
Symbol

Name
ID
Tspear
thrombospondin type laminin G domain and EAR repeats
MGI:2671932
Synonyms
C330046G03Rik, ORF65
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:77829467-77887021 bp, + strand
From VEGA annotation of GRCm38

  57555 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36972  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Tspear

Human
homologs
Human Homolog TSPEAR, thrombospondin-type laminin G domain and EAR repeats
NCBI Gene ID 54084
neXtProt AC  NX_Q8WU66
Human Synonyms  C21orf29, DFNB98, TSP-EAR
Human Chr (Location)  21q22.3; chr21:44497892-44711580 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TSPEAR
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Tspear (3)
Incidental mutations (data from APF )
Alleles Annotated to Human Diseases(1)   
Interactions
Tspear interacts with 93 markers (Mir29a, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process sensory perception of sound
Component cell projection, cell surface, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (39)    Tissues (33)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 21
RT-PCR 18
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(5) Primer pair(2)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000020510 (Evidence)
Ensembl Gene ModelENSMUSG00000069581 (Evidence)
Entrez Gene252974 (Evidence)
UniGene221237
DFCITC1592571
DoTSDT.101308199, DT.101354352
NIA Mouse Gene IndexU011691
International Mouse Knockout Project StatusTspear
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020510 VEGA Gene Model | MGI Sequence Detail 57555 C57BL/6J ±  kb
transcript OTTMUST00000048643 VEGA | MGI Sequence Detail 1706 Not Applicable 
polypeptide OTTMUSP00000022348 VEGA | MGI Sequence Detail 546 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(15) UniProt(1)
Polymorphisms
SNPs within 2kb(137 from dbSNP Build 137)    SNPs within 2kb including multiple locations(139)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR009039 EAR
InterPro IPR001791 Laminin G domain
InterPro IPR005492 Leucine-rich glioma-inactivated , EPTP repeat
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:185976 Delmaghani S, et al., Defect in the gene encoding the EAR/EPTP domain-containing protein TSPEAR causes DFNB98 profound deafness. Hum Mol Genet. 2012 Sep 1;21(17):3835-44
All references(23)
Other
accession IDs
MGI:2652696

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory