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Fez1
Gene Detail
 Symbol
Name
ID
Fez1
fasciculation and elongation protein zeta 1 (zygin I)
MGI:2670976
Synonyms MGC:19293, UNC76, UNC-76
Feature Type protein coding gene
Genetic Map
Chromosome 9
20.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:36821939-36878924 bp, + strand
From VEGA annotation of GRCm38

  56986 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21063  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fez1

Human
homologs
Human Homolog FEZ1, fasciculation and elongation protein zeta 1 (zygin I)
NCBI Gene ID 9638
neXtProt AC  NX_Q99689
Human Chr (Location)  11q24.2; chr11:125445745-125496310 (-)  GRCh38
Alleles
and
phenotypes
All alleles(46) : Gene trapped(44) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit hyperactivity and increased sensitivity to methamphetamine.
 
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process establishment of mitochondrion localization, positive regulation of neuron differentiation, ...
Component axon, cell projection, ...
Function gamma-tubulin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (71)    Tissues (43)   
Theiler Stages: 10, 18, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 16
Northern blot 4
Western blot 49
RT-PCR 2
cDNA source data(52)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(54) cDNA(53) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000034186 (Evidence)
Ensembl Gene ModelENSMUSG00000032118 (Evidence)
Entrez Gene235180 (Evidence)
UniGene5264
DFCITC1576750
DoTSDT.101310048, DT.486714
NIA Mouse Gene IndexU010253
Consensus CDS ProjectCCDS40581.1
International Mouse Knockout Project StatusFez1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034186 VEGA Gene Model | MGI Sequence Detail 56986 C57BL/6J ±  kb
transcript OTTMUST00000086695 VEGA | MGI Sequence Detail 1794 Not Applicable 
polypeptide OTTMUSP00000046953 VEGA | MGI Sequence Detail 392 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(8) UniProt(7)
Polymorphisms SNPs within 2kb(337 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015642 Fasciculation and elongation protein zeta 1
InterPro IPR011680 FEZ-like
Protein Ontology PR:000007466 fasciculation and elongation protein zeta-1
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:178948 Kang E, et al., Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Neuron. 2011 Nov 17;72(4):559-71
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory