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Frem1 Gene Detail
Summary
  • Symbol
    Frem1
  • Name
    Fras1 related extracellular matrix protein 1
  • Synonyms
    crf11, eyem02Jus, eyes2, heb, QBRICK
  • Feature Type
    protein coding gene
  • IDs
    MGI:2670972
    NCBI Gene: 329872
  • Gene Overview
    MyGene.info: FREM1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:82897920-83052339 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 39.40 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1198 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2670972
protein coding gene Chr4:82897920-83052406 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028401
protein coding gene Chr4:82472052-82634680 (-)
A/J MGP_AJ_G0028362
protein coding gene Chr4:79622648-79775377 (-)
AKR/J MGP_AKRJ_G0028311
protein coding gene Chr4:81684282-81840357 (-)
BALB/cJ MGP_BALBcJ_G0028382
protein coding gene Chr4:79852705-80007337 (-)
C3H/HeJ MGP_C3HHeJ_G0028097
protein coding gene Chr4:82267115-82432904 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028821
protein coding gene Chr4:85740502-85900635 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026121
protein coding gene Chr4:75573774-75723970 (-)
CAST/EiJ MGP_CASTEiJ_G0027538
protein coding gene Chr4:80167868-80332592 (-)
CBA/J MGP_CBAJ_G0028066
protein coding gene Chr4:88398413-88557606 (-)
DBA/2J MGP_DBA2J_G0028215
protein coding gene Chr4:79391861-79545525 (-)
FVB/NJ MGP_FVBNJ_G0028181
protein coding gene Chr4:78390881-78546353 (-)
LP/J MGP_LPJ_G0028315
protein coding gene Chr4:82822051-82981137 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028210
protein coding gene Chr4:93491067-93657025 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028858
protein coding gene Chr4:81736399-81896281 (-)
PWK/PhJ MGP_PWKPhJ_G0027261
protein coding gene Chr4:77737073-77893423 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027086
protein coding gene Chr4:79260008-79416175 (-)
WSB/EiJ MGP_WSBEiJ_G0027614
protein coding gene Chr4:81913002-82076612 (-)



Homology
more
  • Human Ortholog
    FREM1, FRAS1 related extracellular matrix 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FREM1, FRAS1 related extracellular matrix 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BNAR, C9orf143, C9orf145, C9orf154, MOTA, TILRR, TRIGNO2
  • Links
    NCBI Gene ID: 158326
    neXtProt AC: NX_Q5H8C1
    UniProt: Q5H8C1

  • Chr Location
    9p22.3; chr9:14734666-14911653 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 27049
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FREM1
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Frem1 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
IDs
View 1 model
IDs
View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 7 alleles in 8 genetic backgrounds
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in subepidermal blistering, cryptophthalmos, syndactyly, and renal agenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059049 Ensembl Gene Model | MGI Sequence Detail 154420 C57BL/6J ±  kb
    transcript ENSMUST00000071708 Ensembl | MGI Sequence Detail 9307 Not Applicable  
    polypeptide ENSMUSP00000071627 Ensembl | MGI Sequence Detail 2191 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 34
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10691, MGI:2671571, MGI:3038384, MGI:96069
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 18
      Diseases 4
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:6609 Varnum DS, et al., Head blebs: a new mutation on chromosome 4 of the mouse. J Hered. 1981 Jul-Aug;72(4):293
    • Latest
      J:262964 Jordan VK, et al., The role of FREM2 and FRAS1 in the development of congenital diaphragmatic hernia. Hum Mol Genet. 2018 Jun 15;27(12):2064-2075

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory