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Frem1
Gene Detail
 Symbol
Name
ID
Frem1
Fras1 related extracellular matrix protein 1
MGI:2670972
Synonyms crf11, eyem02Jus, eyes2, heb, QBRICK
Feature Type protein coding gene
Genetic Map
Chromosome 4
39.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:82897927-83052339 bp, - strand
From VEGA annotation of GRCm38

  154413 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27049  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Frem1

Human
homologs
Human Homolog FREM1, FRAS1 related extracellular matrix 1
NCBI Gene ID 158326
neXtProt AC  NX_Q5H8C1
Human Synonyms  BNAR, C9orf143, C9orf145, C9orf154, MOTA, TILRR, TRIGNO2
Human Chr (Location)  9p22.3; chr9:14734666-14910995 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human FREM1
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(4) Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in subepidermal blistering, cryptophthalmos, syndactyly, and renal agenesis.
 
Human Diseases Modeled Using Mouse Frem1 (4)    Alleles Annotated to Human Diseases(5)    Phenotype Images(2)
Interactions
Frem1 interacts with 341 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell adhesion, cell communication, ...
Component basement membrane, extracellular region, ...
Function carbohydrate binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (111)    Tissues (81)    Images (28)
Theiler Stages: 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 46
RNA in situ 29
RT-PCR 36
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) cDNA(32) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000000404 (Evidence)
Ensembl Gene ModelENSMUSG00000059049 (Evidence)
Entrez Gene329872 (Evidence)
UniGene242337
Consensus CDS ProjectCCDS38791.1, CCDS57281.1
International Mouse Knockout Project StatusFrem1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000404 VEGA Gene Model | MGI Sequence Detail 154413 C57BL/6J ±  kb
transcript OTTMUST00000000974 VEGA | MGI Sequence Detail 9690 Not Applicable 
polypeptide OTTMUSP00000000431 VEGA | MGI Sequence Detail 2172 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(23) UniProt(4)
Polymorphisms SNPs within 2kb(1200 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
InterPro IPR003644 Na-Ca exchanger/integrin-beta4
Protein Ontology PR:000007656 FRAS1-related extracellular matrix protein 1
References (Earliest) J:64448 Varnum DS, et al., heb - head bleb. Mouse News Lett. 1976;55:16
(Latest) J:205063 Wiradjaja F, et al., Regulation of PDGFC signalling and extracellular matrix composition by FREM1 in mice. Dis Model Mech. 2013 Nov;6(6):1426-33
All references(44)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-10691, MGI:2671571, MGI:3038384, MGI:96069

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory