About   Help   FAQ
Wfikkn1 Gene Detail
Summary
  • Symbol
    Wfikkn1
  • Name
    WAP, FS, Ig, KU, and NTR-containing protein 1
  • Synonyms
    Gasp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2670967
    NCBI Gene: 215001
  • Gene Overview
    MyGene.info: WFIKKN1
Location & Maps
more
  • Sequence Map
    Chr17:25877630-25880305 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2676 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.97 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    WFIKKN1, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WFIKKN1, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C16orf12, RJD2, WFDC20A, WFIKKN
  • Links
    NCBI Gene ID: 117166
    neXtProt AC: NX_Q96NZ8

  • Chr Location
    16p13.3; chr16:631012-634116 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    3 images
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    2 involving Wfikkn1
  • Incidental Mutations
Mice homozygous for a null mutation show partial penetrance of posteriorly directed homeotic transformations throughout the axial skeleton, impaired muscle regeneration and a mild decrease in skeletal muscle weight in males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042048 VEGA Gene Model | MGI Sequence Detail 2676 C57BL/6J ±  kb
transcript OTTMUST00000110256 VEGA | MGI Sequence Detail 1981 Not Applicable  
polypeptide OTTMUSP00000061472 VEGA | MGI Sequence Detail 552 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    7 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017412 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR002350 Kazal domain
    IPR001134 Netrin domain
    IPR002223 Pancreatic trypsin inhibitor Kunitz domain
    IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
    IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
    IPR008197 WAP-type 'four-disulfide core' domain
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 2
References
more
  • Summaries
    All 23
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:162988 Kondas K, et al., Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. J Biol Chem. 2008 Aug 29;283(35):23677-84
  • Latest
    J:219045 Dai X, et al., Requirement for integrin-linked kinase in neural crest migration and differentiation and outflow tract morphogenesis. BMC Biol. 2013;11:107

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory