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Med13l Gene Detail
Summary
  • Symbol
    Med13l
  • Name
    mediator complex subunit 13-like
  • Synonyms
    2210413I17Rik, 6330591G05Rik, 9030618F05Rik, mKIAA1025, Thrap2, Trap240L
  • Feature Type
    protein coding gene
  • IDs
    MGI:2670178
    NCBI Gene: 76199
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:118560679-118765438 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 59.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1078 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2670178
protein coding gene Chr5:118560330-118765438 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029997
protein coding gene Chr5:121752863-121966872 (+)
A/J MGP_AJ_G0029961
protein coding gene Chr5:116761203-116968560 (+)
AKR/J MGP_AKRJ_G0029900
protein coding gene Chr5:120531886-120746693 (+)
BALB/cJ MGP_BALBcJ_G0029972
protein coding gene Chr5:118185850-118390829 (+)
C3H/HeJ MGP_C3HHeJ_G0029692
protein coding gene Chr5:121069644-121281579 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030427
protein coding gene Chr5:126370465-126583512 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027653
protein coding gene Chr5:111515580-111724097 (+)
CAST/EiJ MGP_CASTEiJ_G0029101
protein coding gene Chr5:120105693-120322549 (+)
CBA/J MGP_CBAJ_G0029660
protein coding gene Chr5:131258117-131494852 (+)
DBA/2J MGP_DBA2J_G0029810
protein coding gene Chr5:116866318-117073274 (+)
FVB/NJ MGP_FVBNJ_G0029766
protein coding gene Chr5:115761413-115966010 (+)
LP/J MGP_LPJ_G0029898
protein coding gene Chr5:122248386-122461151 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029797
protein coding gene Chr5:135404823-135623967 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030468
protein coding gene Chr5:120099526-120307713 (+)
PWK/PhJ MGP_PWKPhJ_G0028814
protein coding gene Chr5:115586202-115798235 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028652
protein coding gene Chr5:117698013-117939644 (+)
WSB/EiJ MGP_WSBEiJ_G0029176
protein coding gene Chr5:120671335-120880165 (+)



Homology
more
  • Human Ortholog
    MED13L, mediator complex subunit 13L
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MED13L, mediator complex subunit 13L
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRFACD, PROSIT240, THRAP2, TRAP240L
  • Links
    NCBI Gene ID: 23389
    neXtProt AC: NX_Q71F56
    UniProt: Q71F56

  • Chr Location
    12q24.21; chr12:115958576-116277219 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MED13L associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000018076 Ensembl Gene Model | MGI Sequence Detail 204760 C57BL/6J ±  kb
transcript ENSMUST00000201010 Ensembl | MGI Sequence Detail 7781 Not Applicable  
polypeptide ENSMUSP00000144092 Ensembl | MGI Sequence Detail 2216 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000010285 mediator of RNA polymerase II transcription subunit 13-like
  • InterPro Domains
    IPR009401 Mediator complex subunit Med13, C-terminal
    IPR021643 Mediator complex, subunit Med13, N-terminal, metazoa/fungi
    IPR041285 MID domain of medPIWI
Molecular
Reagents
less
  • All nucleic 140
    Genomic 2
    cDNA 138

    Microarray probesets 5
Other
Accession IDs
less
MGI:1918805, MGI:1922081, MGI:1923449
References
more
  • Summaries
    All 49
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 15
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:262706 Miao YL, et al., Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse. Biol Reprod. 2018 Apr 1;98(4):449-464

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory