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Bsx Gene Detail
Summary
  • Symbol
    Bsx
  • Name
    brain specific homeobox
  • Synonyms
    Bsx1a, Bsx1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2669849
    NCBI Gene: 244813
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:40874127-40878962 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 21.65 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2669849
protein coding gene Chr9:40874127-40880057 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034671
protein coding gene Chr9:39125938-39129827 (+)
A/J MGP_AJ_G0034651
protein coding gene Chr9:38114503-38118392 (+)
AKR/J MGP_AKRJ_G0034577
protein coding gene Chr9:38832781-38836668 (+)
BALB/cJ MGP_BALBcJ_G0034642
protein coding gene Chr9:37857773-37861662 (+)
C3H/HeJ MGP_C3HHeJ_G0034353
protein coding gene Chr9:39358026-39361916 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035165
protein coding gene Chr9:40370001-40373810 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032078
protein coding gene Chr9:37740044-37743783 (+)
CAST/EiJ MGP_CASTEiJ_G0033676
protein coding gene Chr9:39083884-39087687 (+)
CBA/J MGP_CBAJ_G0034326
protein coding gene Chr9:41757493-41761380 (+)
DBA/2J MGP_DBA2J_G0034485
protein coding gene Chr9:38047317-38051204 (+)
FVB/NJ MGP_FVBNJ_G0034425
protein coding gene Chr9:37271236-37275126 (+)
LP/J MGP_LPJ_G0034566
protein coding gene Chr9:39400629-39404516 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034469
protein coding gene Chr9:43807193-43811081 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035184
protein coding gene Chr9:38758144-38762031 (+)
PWK/PhJ MGP_PWKPhJ_G0033381
protein coding gene Chr9:37859606-37863422 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033217
protein coding gene Chr9:38985718-38989496 (+)
WSB/EiJ MGP_WSBEiJ_G0033789
protein coding gene Chr9:38784439-38788327 (+)



Homology
more
  • Human Ortholog
    BSX, brain specific homeobox
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BSX, brain specific homeobox
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BSX1
  • Links
    NCBI Gene ID: 390259
    neXtProt AC: NX_Q3C1V8
    UniProt: Q3C1V8

  • Chr Location
    11q24.1; chr11:122977649-122981671 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 65347
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BSX
  • Gene Tree
    Bsx
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 4 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for mutations in Bsx display increased fat mass, decreased food intake after fasting, decreased body temperature, and reduced locomotor activity, but body weight and glucose homoeostasis are similar to wild-type.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 244813 NCBI Gene Model | MGI Sequence Detail 4836 C57BL/6J ±  kb
    transcript NM_178245 RefSeq | MGI Sequence Detail 875 C57BL/6  
    polypeptide Q810B3 UniProt | EBI | MGI Sequence Detail 232 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Other 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:87378 Cremona M, et al., Bsx, an evolutionary conserved Brain Specific homeoboX gene expressed in the septum, epiphysis, mammillary bodies and arcuate nucleus. Gene Expr Patterns. 2004 Jan;4(1):47-51
    • Latest
      J:266266 Newman EA, et al., Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus. Dev Biol. 2018 Oct 15;442(2):236-248

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory