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Rtn4rl2
Gene Detail
Symbol

Name
ID
Rtn4rl2
reticulon 4 receptor-like 2
MGI:2669796
Synonyms
Ngr2, Ngrh1, Ngrl3
Feature Type
protein coding gene
Genetic Map
Chromosome 2
49.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:84871924-84886710 bp, - strand
From VEGA annotation of GRCm38

  14787 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18683  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 2 zebrafish

HCOP human homology predictions: RTN4RL2
Gene Tree: Rtn4rl2

Human
homologs
RTN4RL2, reticulon 4 receptor-like 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 349667
neXtProt AC: NX_Q86UN3

Human Synonyms: NgR2, NGRH1

Human Chr (Location): 11q12.1; chr11:57460537-57477539 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Genomic Mutations involving Rtn4rl2 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display a normal phenotype.
 
Interactions
Rtn4rl2 interacts with 4 markers (Mir377, Mir672, Mir744, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process axon regeneration
Component anchored component of membrane, anchored component of plasma membrane, ...
Function receptor activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (158)    Tissues (76)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 150
RT-PCR 8
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN rtn4rl2a, rtn4rl2b    NEW 
Molecular
reagents
All nucleic(8) cDNA(5) Primer pair(3)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000013729 (Evidence)
Ensembl Gene Model ENSMUSG00000050896 (Evidence)
Entrez Gene 269295 (Evidence)
DFCI TC1604776
DoTS DT.97403975
NIA Mouse Gene Index U073841
Consensus CDS Project CCDS16197.1
International Mouse Phenotyping Consortium Status Rtn4rl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013729 VEGA Gene Model | MGI Sequence Detail 14787 C57BL/6J ±  kb
transcript OTTMUST00000032896 VEGA | MGI Sequence Detail 1303 Not Applicable 
polypeptide OTTMUSP00000014701 VEGA | MGI Sequence Detail 426 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat N-terminal domain
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000014352 reticulon-4 receptor-like 2
References
(Earliest) J:83107 Pignot V, et al., Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. J Neurochem. 2003 May;85(3):717-28
(Latest) J:210222 Hupe M, et al., Evaluation of TRAP-sequencing technology with a versatile conditional mouse model. Nucleic Acids Res. 2014 Jan;42(2):e14
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory