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Rtn4rl2 Gene Detail
Summary
  • Symbol
    Rtn4rl2
  • Name
    reticulon 4 receptor-like 2
  • Synonyms
    Ngr2, Ngrh1, Ngrl3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2669796
    NCBI Gene: 269295
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84871924-84886710 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 49.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2669796
protein coding gene Chr2:84871297-84888437 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025915
protein coding gene Chr2:85573155-85589066 (-)
A/J MGP_AJ_G0025889
protein coding gene Chr2:82266176-82280952 (-)
AKR/J MGP_AKRJ_G0025859
protein coding gene Chr2:84387731-84402517 (-)
BALB/cJ MGP_BALBcJ_G0025886
protein coding gene Chr2:82393300-82408524 (-)
C3H/HeJ MGP_C3HHeJ_G0025645
protein coding gene Chr2:84625871-84641610 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026332
protein coding gene Chr2:88223750-88241555 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023734
protein coding gene Chr2:79091401-79106252 (-)
CAST/EiJ MGP_CASTEiJ_G0025106
protein coding gene Chr2:85159115-85177475 (-)
CBA/J MGP_CBAJ_G0025626
protein coding gene Chr2:91372135-91389035 (-)
DBA/2J MGP_DBA2J_G0025757
protein coding gene Chr2:81797257-81812006 (-)
FVB/NJ MGP_FVBNJ_G0025720
protein coding gene Chr2:81056157-81071574 (-)
LP/J MGP_LPJ_G0025845
protein coding gene Chr2:85366798-85382694 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025750
protein coding gene Chr2:93691166-93705886 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026388
protein coding gene Chr2:84630209-84644977 (-)
PWK/PhJ MGP_PWKPhJ_G0024850
protein coding gene Chr2:81641301-81656172 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024654
protein coding gene Chr2:84762057-84776852 (-)
WSB/EiJ MGP_WSBEiJ_G0025176
protein coding gene Chr2:85285999-85300809 (-)



Homology
more
  • Human Ortholog
    RTN4RL2, reticulon 4 receptor like 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RTN4RL2, reticulon 4 receptor like 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NgR2, NGRH1
  • Links
    NCBI Gene ID: 349667
    neXtProt AC: NX_Q86UN3
    UniProt: Q86UN3

  • Chr Location
    11q12.1; chr11:57460537-57477539 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 4 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 phenotype references
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050896 Ensembl Gene Model | MGI Sequence Detail 14787 C57BL/6J ±  kb
transcript ENSMUST00000151799 Ensembl | MGI Sequence Detail 1303 Not Applicable  
polypeptide ENSMUSP00000118362 Ensembl | MGI Sequence Detail 426 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 9
    cDNA 6
    Primer pair 3

    Microarray probesets 1
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:83107 Pignot V, et al., Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. J Neurochem. 2003 May;85(3):717-28
  • Latest
    J:253213 Zhao Y, et al., Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels. Neuron. 2017 Oct 11;96(2):355-372.e6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory