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Wfikkn2 Gene Detail
Summary
  • Symbol
    Wfikkn2
  • Name
    WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
  • Synonyms
    2610304F08Rik, Gasp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2669209
    NCBI Gene: 278507
  • Gene Overview
    MyGene.info: WFIKKN2
Location & Maps
more
  • Sequence Map
    Chr11:94235956-94246005 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10050 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 58.90 cM, cytoband C
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    WFIKKN2, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    WFIKKN2, WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GASP-1, hGASP-1, WFDC20B, WFIKKNRP
  • Links
    NCBI Gene ID: 124857
    neXtProt AC: NX_Q8TEU8

  • Chr Location
    17q21.33; chr17:50835244-50842348 (+)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    3 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    1
  • Targeted
    8
  • Genomic Mutations
    3 involving Wfikkn2
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a null mutation show impaired muscle regeneration and a mild decrease in skeletal muscle weight in males.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001708 VEGA Gene Model | MGI Sequence Detail 10050 C57BL/6J ±  kb
transcript OTTMUST00000003368 VEGA | MGI Sequence Detail 3516 Not Applicable  
polypeptide OTTMUSP00000001613 VEGA | MGI Sequence Detail 571 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    133 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000017413 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
  • InterPro Domains
    IPR013098 Immunoglobulin I-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR002350 Kazal domain
    IPR001134 Netrin domain
    IPR018933 Netrin module, non-TIMP type
    IPR002223 Pancreatic trypsin inhibitor Kunitz domain
    IPR020901 Proteinase inhibitor I2, Kunitz, conserved site
    IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
    IPR008197 WAP-type 'four-disulfide core' domain
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917718
References
more
  • Summaries
    All 30
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:201148 Lee YS, et al., Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):E3713-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory