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Tmc8
Gene Detail
Symbol

Name
ID
Tmc8
transmembrane channel-like gene family 8
MGI:2669037
Synonyms
Ever2, EVIN2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
82.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:117782076-117793110 bp, + strand
From VEGA annotation of GRCm38

  11035 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:45126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Tmc8

Human
homologs
Human Homolog TMC8, transmembrane channel-like 8
NCBI Gene ID 147138
neXtProt AC  NX_Q8IU68
Human Synonyms  EV2, EVER2, EVIN2
Human Chr (Location)  17q25.3; chr17:78129424-78142968 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TMC8
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tmc8 interacts with 115 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process ion transport, negative regulation of protein binding, ...
Component cytoplasm, endoplasmic reticulum, ...
Function receptor binding
External Resources: FuncBase
Expression
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(15)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000003679 (Evidence)
Ensembl Gene ModelENSMUSG00000050106 (Evidence)
Entrez Gene217356 (Evidence)
UniGene116675
DFCITC1675917, TC1584292
DoTSDT.482316, DT.91417710, DT.91396970, DT.94295828
NIA Mouse Gene IndexU043246
Consensus CDS ProjectCCDS25689.1, CCDS56824.1, CCDS56825.1
International Mouse Knockout Project StatusTmc8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003679 VEGA Gene Model | MGI Sequence Detail 11035 C57BL/6J ±  kb
transcript OTTMUST00000077131 VEGA | MGI Sequence Detail 2736 Not Applicable 
polypeptide OTTMUSP00000040717 VEGA | MGI Sequence Detail 723 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(19) UniProt(9)
Polymorphisms
SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012496 TMC
Protein Ontology PR:000016399 transmembrane channel-like protein 8
References
(Earliest) J:84240 Keresztes G, et al., TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. BMC Genomics. 2003 Jun 17;4(1):24
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory