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Tmc8 Gene Detail
Summary
  • Symbol
    Tmc8
  • Name
    transmembrane channel-like gene family 8
  • Synonyms
    Ever2, EVIN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2669037
    NCBI Gene: 217356
  • Gene Overview
    MyGene.info: TMC8
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:117782076-117793110 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 82.96 cM
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2669037
protein coding gene Chr11:117781594-117793137 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019450
protein coding gene Chr11:122063019-122074108 (+)
A/J MGP_AJ_G0019418
protein coding gene Chr11:116652314-116663390 (+)
AKR/J MGP_AKRJ_G0019388
protein coding gene Chr11:120201443-120214163 (+)
BALB/cJ MGP_BALBcJ_G0019393
protein coding gene Chr11:117024462-117036040 (+)
C3H/HeJ MGP_C3HHeJ_G0019199
protein coding gene Chr11:120480556-120491621 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019842
protein coding gene Chr11:125783793-125796425 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017467
protein coding gene Chr11:113660580-113672408 (+)
CAST/EiJ MGP_CASTEiJ_G0018753
protein coding gene Chr11:121914914-121926053 (+)
CBA/J MGP_CBAJ_G0019170
protein coding gene Chr11:130742075-130755556 (+)
DBA/2J MGP_DBA2J_G0019282
protein coding gene Chr11:116052784-116064716 (+)
FVB/NJ MGP_FVBNJ_G0019274
protein coding gene Chr11:115673355-115685189 (+)
LP/J MGP_LPJ_G0019352
protein coding gene Chr11:122385909-122397753 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019307
protein coding gene Chr11:129704908-129715933 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019881
protein coding gene Chr11:120850009-120861152 (+)
PWK/PhJ MGP_PWKPhJ_G0018519
protein coding gene Chr11:117409997-117421196 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018311
protein coding gene Chr11:120581971-120593924 (+)
WSB/EiJ MGP_WSBEiJ_G0018805
protein coding gene Chr11:120819820-120831631 (+)



Homology
more
  • Human Ortholog
    TMC8, transmembrane channel like 8
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TMC8, transmembrane channel like 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EV2, EVER2, EVIN2
  • Links
    NCBI Gene ID: 147138
    neXtProt AC: NX_Q8IU68
    UniProt: Q8IU68

  • Chr Location
    17q25.3; chr17:78129296-78142968 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TMC8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050106 Ensembl Gene Model | MGI Sequence Detail 11035 C57BL/6J ±  kb
transcript ENSMUST00000119455 Ensembl | MGI Sequence Detail 2736 Not Applicable  
polypeptide ENSMUSP00000113628 Ensembl | MGI Sequence Detail 723 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 2
    cDNA 15

    Microarray probesets 2
References
more
  • Summaries
    All 31
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:84240 Keresztes G, et al., TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. BMC Genomics. 2003 Jun 17;4(1):24
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory