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C8a
Gene Detail
Symbol

Name
ID
C8a
complement component 8, alpha polypeptide
MGI:2668347
Feature Type
protein coding gene
Genetic Map
Chromosome 4
48.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:104815679-104876398 bp, - strand
From VEGA annotation of GRCm38

  60720 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:472  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: C8A
Gene Tree: C8a

Human
homologs
C8A, complement component 8, alpha polypeptide
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 731
neXtProt AC: NX_P07357

Human Chr (Location): 1p32; chr1:56854770-56918221 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human C8A

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving C8a (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
C8a interacts with 252 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process complement activation, complement activation, alternative pathway, ...
Component blood microparticle, extracellular exosome, ...
Function complement binding, protein complex binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase c8a ; ZFIN c8a    NEW 
Molecular
reagents
All nucleic(23) cDNA(23)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000008116 (Evidence)
Ensembl Gene Model ENSMUSG00000035031 (Evidence)
Entrez Gene 230558 (Evidence)
UniGene 197638
DFCI TC1584206, TC1653380
DoTS DT.481127, DT.99586847
NIA Mouse Gene Index U025316
Consensus CDS Project CCDS18415.1, CCDS71433.1
International Mouse Phenotyping Consortium Status C8a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008116 VEGA Gene Model | MGI Sequence Detail 60720 C57BL/6J ±  kb
transcript OTTMUST00000018447 VEGA | MGI Sequence Detail 3617 Not Applicable 
polypeptide OTTMUSP00000008475 VEGA | MGI Sequence Detail 587 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(449 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR001862 Membrane attack complex component/perforin/complement C9
InterPro IPR020863 Membrane attack complex component/perforin domain, conserved site
InterPro IPR020864 Membrane attack complex component/perforin (MACPF) domain
InterPro IPR000884 Thrombospondin type-1 (TSP1) repeat
Protein Ontology PR:000004908 complement component C8 alpha chain
References
(Earliest) J:81997 Bar I, et al., The gene encoding disabled-1 (DAB1), the intracellular adaptor of the Reelin pathway, reveals unusual complexity in human and mouse. J Biol Chem. 2003 Feb 21;278(8):5802-12
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory