About   Help   FAQ
C8a
Gene Detail
Symbol

Name
ID
C8a
complement component 8, alpha polypeptide
MGI:2668347
Feature Type
protein coding gene
Genetic Map
Chromosome 4
48.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:104815679-104876398 bp, - strand
From VEGA annotation of GRCm38

  60720 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:472  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: C8a

Human
homologs
Human Homolog C8A, complement component 8, alpha polypeptide
NCBI Gene ID 731
neXtProt AC  NX_P07357
Human Chr (Location)  1p32; chr1:56854770-56918221 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human C8A
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
C8a interacts with 252 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process complement activation, complement activation, alternative pathway, ...
Component blood microparticle, extracellular region, ...
Function complement binding, protein complex binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(23)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008116 (Evidence)
Ensembl Gene ModelENSMUSG00000035031 (Evidence)
Entrez Gene230558 (Evidence)
UniGene197638
DFCITC1653380, TC1584206
DoTSDT.99586847, DT.481127
NIA Mouse Gene IndexU025316
Consensus CDS ProjectCCDS18415.1, CCDS71433.1
International Mouse Knockout Project StatusC8a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008116 VEGA Gene Model | MGI Sequence Detail 60720 C57BL/6J ±  kb
transcript OTTMUST00000018447 VEGA | MGI Sequence Detail 3617 Not Applicable 
polypeptide OTTMUSP00000008475 VEGA | MGI Sequence Detail 587 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(10) UniProt(9)
Polymorphisms
SNPs within 2kb(449 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR001862 Membrane attack complex component/perforin/complement C9
InterPro IPR020863 Membrane attack complex component/perforin domain, conserved site
InterPro IPR020864 Membrane attack complex component/perforin (MACPF) domain
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000004908 complement component C8 alpha chain
References
(Earliest) J:81997 Bar I, et al., The gene encoding disabled-1 (DAB1), the intracellular adaptor of the Reelin pathway, reveals unusual complexity in human and mouse. J Biol Chem. 2003 Feb 21;278(8):5802-12
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory