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Serpina10
Gene Detail
 Symbol
Name
ID
Serpina10
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
MGI:2667725
Synonyms PZI
Feature Type protein coding gene
Genetic Map
Chromosome 12
52.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:103614786-103631444 bp, - strand
From VEGA annotation of GRCm38

  16659 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9414  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Serpina10

Human
homologs
Human Homolog SERPINA10, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
NCBI Gene ID 51156
neXtProt AC  NX_Q9UK55
Human Synonyms  PZI, ZPI
Human Chr (Location)  14q32.13; chr14:94283311-94293271 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display a reduced survival rate, enhanced thrombosis after ferric chloride-induced carotid artery injury, and increased mortality from pulmonary thromboembolism following collagen/epinephrine infusion.
 
Interactions
Serpina10 interacts with 51 markers (Mir1b, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process blood coagulation, hemostasis, ...
Component extracellular region, extracellular space, ...
Function heparin binding, peptidase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (232)    Tissues (179)    Images (51)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 232
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(41)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026297 (Evidence)
Ensembl Gene ModelENSMUSG00000061947 (Evidence)
Entrez Gene217847 (Evidence)
UniGene29094
DFCITC1581019, TC1608273
DoTSDT.492084, DT.97390962
NIA Mouse Gene IndexU034297
PDB4AJT
Consensus CDS ProjectCCDS26134.1
International Mouse Knockout Project StatusSerpina10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026297 VEGA Gene Model | MGI Sequence Detail 16659 C57BL/6J ±  kb
transcript OTTMUST00000065055 VEGA | MGI Sequence Detail 3498 Not Applicable 
polypeptide OTTMUSP00000032368 VEGA | MGI Sequence Detail 448 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(109 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014679 protein Z-dependent protease inhibitor
References (Earliest) J:82699 Forsyth S, et al., A review and comparison of the murine alpha(1)-antitrypsin and alpha(1)-antichymotrypsin multigene clusters with the human clade A serpins. Genomics. 2003 Mar;81(3):336-45
(Latest) J:195454 Girard TJ, et al., Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response. J Thromb Haemost. 2013 Feb;11(2):375-8
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory