Irgq Gene Detail

Summary

• Symbol
  Irgq
• Name
  immunity-related GTPase family, Q
• Synonyms
  FKSG27

• Feature Type
  protein coding gene
• IDs
  MGI:2667176
  NCBI Gene: 210146
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr7:24530689-24538600 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    7912 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 11.32 cM
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  IRGQ, immunity related GTPase Q

• Vertebrate Orthologs
  7

• Human Ortholog
  IRGQ, immunity related GTPase Q
  Orthology source: HomoloGene, HGNC
• Synonyms
  FKSG27, IRGQ1
• Links
  HGNC:24868

  NCBI Gene ID: 126298

  neXtProt AC: NX_Q8WZA9

  UniProt: Q8WZA9

  
  
• Chr Location
  19q13.31; chr19:43584367-43596234 (-)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 17696
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
  
• HCOP
  human homology predictions: IRGQ
• Gene Tree
  Irgq
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotype references
  

• All Mutations and Alleles
  5
• Gene trapped
  2
• Targeted
  3
• Incidental Mutations
  APF , CvDC
• Find Mice (IMSR)
  8 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

• External Resources
  FuncBase

Expression

• cDNA Data
  103

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase irgq

Interactions

• Irgq interacts with 349 markers (Mir1b, Mir7-1, Mir9-1, ...) View All

Sequences &
Gene Models

• All Sequences
  21
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS20953.1
• UniGene
  41108

• VEGA
  OTTMUSG00000058219 (Evidence)
• Ensembl
  ENSMUSG00000041037 (Evidence)
• NCBI Gene
  210146

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000058219	VEGA Gene Model | MGI Sequence Detail	7912	C57BL/6J
transcript	OTTMUST00000142990	VEGA | MGI Sequence Detail	6083	Not Applicable
polypeptide	OTTMUSP00000074568	VEGA | MGI Sequence Detail	583	Not Applicable

Polymorphisms

• SNPs within 2kb
  43 from dbSNP Build 142

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000029561 immunity-related GTPase family Q protein
  (term hierarchy)
• InterPro Domains
  IPR030385 IRG-type guanine nucleotide-binding (G) domain

Molecular
Reagents

• All nucleic 103

  cDNA 103

  
  

  Microarray probesets 6

References

• Summaries
  All 26

  Gene Ontology 1

  Phenotypes 5
• Earliest
  J:150323 Miyairi I, et al., The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infection. J Immunol. 2007 Aug 1;179(3):1814-24
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42