Irgq Gene Detail

Summary

• Symbol
  Irgq
• Name
  immunity-related GTPase family, Q
• Synonyms
  FKSG27

• Feature Type
  protein coding gene
• IDs
  MGI:2667176
  NCBI Gene: 210146
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr7:24530689-24538600 bp, + strand
• From Ensembl annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 11.32 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  43 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2667176	protein coding gene	Chr7:24530648-24538600 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031832	protein coding gene	Chr7:22858837-22866744 (+)
A/J	MGP_AJ_G0031811	protein coding gene	Chr7:22333945-22341793 (+)
AKR/J	MGP_AKRJ_G0031740	protein coding gene	Chr7:22835378-22843225 (+)
BALB/cJ	MGP_BALBcJ_G0031817	protein coding gene	Chr7:22553731-22561649 (+)
C3H/HeJ	MGP_C3HHeJ_G0031537	protein coding gene	Chr7:23254643-23262547 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032280	protein coding gene	Chr7:23613258-23621174 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029338	protein coding gene	Chr7:23803152-23811298 (+)
CAST/EiJ	MGP_CASTEiJ_G0030878	protein coding gene	Chr7:16729850-16737723 (+)
CBA/J	MGP_CBAJ_G0031502	protein coding gene	Chr7:24501770-24509700 (+)
DBA/2J	MGP_DBA2J_G0031656	protein coding gene	Chr7:22247775-22255710 (+)
FVB/NJ	MGP_FVBNJ_G0031609	protein coding gene	Chr7:22218572-22226490 (+)
LP/J	MGP_LPJ_G0031735	protein coding gene	Chr7:23219609-23227604 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031646	protein coding gene	Chr7:24265571-24273446 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032312	protein coding gene	Chr7:22558020-22565931 (+)
PWK/PhJ	MGP_PWKPhJ_G0030602	protein coding gene	Chr7:17139740-17147762 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030432	protein coding gene	Chr7:13886124-13893940 (+)
WSB/EiJ	MGP_WSBEiJ_G0030981	protein coding gene	Chr7:22678997-22686908 (+)

Homology

• Human Ortholog
  IRGQ, immunity related GTPase Q

• Vertebrate Orthologs
  7

• Human Ortholog
  IRGQ, immunity related GTPase Q
  Orthology source: HomoloGene, HGNC
• Synonyms
  FKSG27, IRGQ1
• Links
  HGNC:24868

  NCBI Gene ID: 126298

  neXtProt AC: NX_Q8WZA9

  UniProt: Q8WZA9

  
  
• Chr Location
  19q13.31; chr19:43584367-43596234 (-)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 17696
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
  
• HCOP
  human homology predictions: IRGQ
• Gene Tree
  Irgq
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotype references
  

• All Mutations and Alleles
  5
• Gene trapped
  2
• Targeted
  3
• Incidental Mutations
  APF , CvDC
• Find Mice (IMSR)
  10 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

• External Resources
  FuncBase

Expression

• cDNA Data
  104

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase irgq

Interactions

• Irgq interacts with 349 markers (Mir1b, Mir7-1, Mir9-1, ...) View All

Sequences &
Gene Models

• All Sequences
  36
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS20953.1
• UniGene
  41108

• Ensembl
  ENSMUSG00000041037 (Evidence)
• NCBI Gene
  210146

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000041037	Ensembl Gene Model | MGI Sequence Detail	7912	C57BL/6J
transcript	ENSMUST00000049020	Ensembl | MGI Sequence Detail	6083	Not Applicable
polypeptide	ENSMUSP00000036699	Ensembl | MGI Sequence Detail	583	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000029561 immunity-related GTPase family Q protein
  (term hierarchy)
• InterPro Domains
  IPR040070 Immunity-related GTPase family Q protein
  IPR030385 IRG-type guanine nucleotide-binding (G) domain

Molecular
Reagents

• All nucleic 104

  cDNA 104

  
  

  Microarray probesets 6

References

• Summaries
  All 26

  Gene Ontology 1

  Phenotypes 5
• Earliest
  J:150323 Miyairi I, et al., The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infection. J Immunol. 2007 Aug 1;179(3):1814-24
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Irgq:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65002	Chr7:24530645-24530693 (+)	-20 bp
Tssr65003	Chr7:24530723-24530734 (+)	40 bp
Tssr65004	Chr7:24530817-24530841 (+)	140 bp
Tssr2133	Chr7:24530935-24530942 (+)	250 bp
Tssr65005	Chr7:24531411-24531423 (+)	728 bp