Irgq MGI Mouse Gene Detail - MGI:2667176 - immunity-related GTPase family, Q

Symbol

Irgq
Name

immunity-related GTPase family, Q
Synonyms

FKSG27

Feature Type

protein coding gene
IDs

MGI:2667176
NCBI Gene: 210146
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:24230114-24238025 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 11.32 cM
Mapping Data

1 experiment

SNPs within 2kb

295 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2667176	protein coding gene	Chr7:24230073-24238025 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031832	protein coding gene	Chr7:22858837-22866744 (+)
A/J	MGP_AJ_G0031811	protein coding gene	Chr7:22333945-22341793 (+)
AKR/J	MGP_AKRJ_G0031740	protein coding gene	Chr7:22835378-22843225 (+)
BALB/cJ	MGP_BALBcJ_G0031817	protein coding gene	Chr7:22553731-22561649 (+)
C3H/HeJ	MGP_C3HHeJ_G0031537	protein coding gene	Chr7:23254643-23262547 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032280	protein coding gene	Chr7:23613258-23621174 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029338	protein coding gene	Chr7:23803152-23811298 (+)
CAST/EiJ	MGP_CASTEiJ_G0030878	protein coding gene	Chr7:16729850-16737723 (+)
CBA/J	MGP_CBAJ_G0031502	protein coding gene	Chr7:24501770-24509700 (+)
DBA/2J	MGP_DBA2J_G0031656	protein coding gene	Chr7:22247775-22255710 (+)
FVB/NJ	MGP_FVBNJ_G0031609	protein coding gene	Chr7:22218572-22226490 (+)
LP/J	MGP_LPJ_G0031735	protein coding gene	Chr7:23219609-23227604 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031646	protein coding gene	Chr7:24265571-24273446 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032312	protein coding gene	Chr7:22558020-22565931 (+)
PWK/PhJ	MGP_PWKPhJ_G0030602	protein coding gene	Chr7:17139740-17147762 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030432	protein coding gene	Chr7:13886124-13893940 (+)
WSB/EiJ	MGP_WSBEiJ_G0030981	protein coding gene	Chr7:22678997-22686908 (+)

Human Ortholog

IRGQ, immunity related GTPase Q

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IRGQ, immunity related GTPase Q
Synonyms

FKSG27, IRGQ1
Links

HGNC:24868

NCBI Gene ID: 126298

UniProt: Q8WZA9
Chr Location

19q13.31; chr19:43584367-43596134 (-) GRCh38

MGI Vertebrate Homology

Irgq stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IRGQ
Gene Tree

Irgq

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

1
Targeted

3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

25
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

104
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase irgq

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All Sequences

36
RefSeq

2
UniProt

1
CCDS

CCDS20953.1

Ensembl

ENSMUSG00000041037 (Evidence)
NCBI Gene

210146

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041037	Ensembl Gene Model \| MGI Sequence Detail	7912	C57BL/6J	± kb
transcript	ENSMUST00000049020	Ensembl \| MGI Sequence Detail	6083	Not Applicable
polypeptide	ENSMUSP00000036699	Ensembl \| MGI Sequence Detail	583	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000029561 immunity-related GTPase family Q protein

(term hierarchy)
InterPro Domains

IPR040070 Immunity-related GTPase family Q protein

IPR030385 IRG-type guanine nucleotide-binding (G) domain
GlyGen

Q8VIM9 2 sites

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All nucleic 104

cDNA 104

Microarray probesets 6

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 8
Earliest

J:150323 Miyairi I, et al., The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and inflammation to murine Chlamydia psittaci infection. J Immunol. 2007 Aug 1;179(3):1814-24
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Irgq:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65002	Chr7:24230070-24230118 (+)	-20 bp
Tssr65003	Chr7:24230148-24230159 (+)	40 bp
Tssr65004	Chr7:24230242-24230266 (+)	140 bp
Tssr2133	Chr7:24230360-24230367 (+)	250 bp
Tssr65005	Chr7:24230836-24230848 (+)	728 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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