About   Help   FAQ
Prss42
Gene Detail
 Symbol
Name
ID
Prss42
protease, serine 42
MGI:2665280
Synonyms Tessp2
Feature Type protein coding gene
Genetic Map
Chromosome 9
60.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:110798185-110803736 bp, + strand
From Ensembl annotation of GRCm38

  5552 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27410  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: trypsin
Gene Tree: Prss42

Human
homologs
Human Homolog PRSS42, protease, serine, 42
NCBI Gene ID 339906
neXtProt AC  NX_Q7Z5A4
Human Synonyms  TESSP2
Human Chr (Location)  3p21.31; chr3:46830404-46834095 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(2) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Prss42 interacts with 115 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process germ cell development, proteolysis, ...
Component anchored component of plasma membrane, cytoplasm, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(2)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(2) cDNA(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000044664 (Evidence)
Entrez Gene235628 (Evidence)
UniGene292285
DFCITC1589244
DoTSDT.94237677
NIA Mouse Gene IndexU011073
EC3.4.21.-
Consensus CDS ProjectCCDS23572.1
International Mouse Knockout Project StatusPrss42
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044664 Ensembl Gene Model | MGI Sequence Detail 5552 C57BL/6J ±  kb
transcript ENSMUST00000035715 Ensembl | MGI Sequence Detail 1547 Not Applicable 
polypeptide ENSMUSP00000041088 Ensembl | MGI Sequence Detail 335 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(56 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000031693 serine protease 42
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:202067 Yoneda R, et al., Three testis-specific paralogous serine proteases play different roles in murine spermatogenesis and are involved in germ cell survival during meiosis. Biol Reprod. 2013 May;88(5):118
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory