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Zfp628 Gene Detail
Summary
  • Symbol
    Zfp628
  • Name
    zinc finger protein 628
  • Synonyms
    Zec
  • Feature Type
    protein coding gene
  • IDs
    MGI:2665174
    NCBI Gene: 232816
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4918216-4925001 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 2.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2665174
 protein coding gene Chr7:4918181-4925002 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031568
 protein coding gene Chr7:1868581-1875367 (+)
A/J MGP_AJ_G0031542
 protein coding gene Chr7:1875701-1882487 (+)
AKR/J MGP_AKRJ_G0031471
 protein coding gene Chr7:1946473-1953259 (+)
BALB/cJ MGP_BALBcJ_G0031550
 protein coding gene Chr7:1909688-1916474 (+)
C3H/HeJ MGP_C3HHeJ_G0031271
 protein coding gene Chr7:1927678-1934492 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032011
 protein coding gene Chr7:1932981-1939767 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029135
 protein coding gene Chr7:1594501-1601197 (+)
CAST/EiJ MGP_CASTEiJ_G0030635
 protein coding gene Chr7:1856352-1863106 (+)
CBA/J MGP_CBAJ_G0031229
 protein coding gene Chr7:2144869-2151655 (+)
DBA/2J MGP_DBA2J_G0031388
 protein coding gene Chr7:1845914-1852700 (+)
FVB/NJ MGP_FVBNJ_G0031340
 protein coding gene Chr7:1802935-1809721 (+)
LP/J MGP_LPJ_G0031473
 protein coding gene Chr7:1970375-1977161 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031379
 protein coding gene Chr7:2102493-2109279 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032041
 protein coding gene Chr7:1848691-1855481 (+)
PWK/PhJ MGP_PWKPhJ_G0030363
 protein coding gene Chr7:2011038-2017790 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030188
 protein coding gene Chr7:1893031-1899774 (+)
WSB/EiJ MGP_WSBEiJ_G0030730
 protein coding gene Chr7:1865997-1872781 (+)



Homology
more
  • Human Ortholog
    ZNF628, zinc finger protein 628
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF628, zinc finger protein 628
  • Synonyms
    ZEC, Zfp628
  • Links
    NCBI Gene ID: 89887
    neXtProt AC: NX_Q5EBL2
    UniProt: Q5EBL2

  • Chr Location
    19q13.42; chr19:55476617-55484487 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null allele display decreased testes size, arrest of spermiogenesis, azoospermia, abnormal acrosomal caps and male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    25
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074406 Ensembl Gene Model | MGI Sequence Detail 6786 C57BL/6J ±  kb
    transcript ENSMUST00000116354 Ensembl | MGI Sequence Detail 3523 Not Applicable  
    polypeptide ENSMUSP00000112058 Ensembl | MGI Sequence Detail 1038 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 4
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:292511 Gustafson EA, et al., ZFP628 Is a TAF4b-Interacting Transcription Factor Required for Mouse Spermiogenesis. Mol Cell Biol. 2020 Mar 16;40(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory