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Il22ra2
Gene Detail
 Symbol
Name
ID
Il22ra2
interleukin 22 receptor, alpha 2
MGI:2665114
Synonyms Il-22bp
Feature Type protein coding gene
Genetic Map
Chromosome 10
8.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:19621998-19634681 bp, + strand
From VEGA annotation of GRCm38

  12684 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18657  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Il22ra2

Human
homologs
Human Homolog IL22RA2, interleukin 22 receptor, alpha 2
NCBI Gene ID 116379
neXtProt AC  NX_Q969J5
Human Synonyms  CRF2-10, CRF2-S1, CRF2X, IL-22BP, IL-22RA2, IL-22R-alpha-2, ZCYTOR16
Human Chr (Location)  6q23.3; chr6:137143820-137173648 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display accelerated tumor formation in a colitis associated colon cancer model.
 
Interactions
Il22ra2 interacts with 190 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cytokine-mediated signaling pathway, negative regulation of inflammatory response, ...
Component cytosol, extracellular region
Function interleukin-22 binding, interleukin-22 receptor activity, ...
External Resources: FuncBase
Expression
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000028020 (Evidence)
Ensembl Gene ModelENSMUSG00000039760 (Evidence)
Entrez Gene237310 (Evidence)
UniGene331979
DFCITC1591028, TC1711818
DoTSDT.91420443
NIA Mouse Gene IndexU011311
Consensus CDS ProjectCCDS23717.1
International Mouse Knockout Project StatusIl22ra2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028020 VEGA Gene Model | MGI Sequence Detail 12684 C57BL/6J ±  kb
transcript OTTMUST00000069396 VEGA | MGI Sequence Detail 2498 Not Applicable 
polypeptide OTTMUSP00000035241 VEGA | MGI Sequence Detail 230 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015373 Interferon alpha/beta receptor, beta chain
Protein Ontology PR:000009000 interleukin-22 receptor subunit alpha-2
References (Earliest) J:83521 Wei CC, et al., Cloning and characterization of mouse IL-22 binding protein. Genes Immun. 2003 Apr;4(3):204-11
(Latest) J:189217 Huber S, et al., IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 2012 Nov 8;491(7423):259-63
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory