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Il22ra2 Gene Detail
Summary
  • Symbol
    Il22ra2
  • Name
    interleukin 22 receptor, alpha 2
  • Synonyms
    Il-22bp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2665114
    NCBI Gene: 237310
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:19622028-19634681 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 8.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2665114
protein coding gene Chr10:19621998-19634681 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017046
protein coding gene Chr10:17347063-17360664 (+)
A/J MGP_AJ_G0017024
protein coding gene Chr10:16691239-16704039 (+)
AKR/J MGP_AKRJ_G0016988
protein coding gene Chr10:16965967-16978648 (+)
BALB/cJ MGP_BALBcJ_G0016982
protein coding gene Chr10:16745981-16758620 (+)
C3H/HeJ MGP_C3HHeJ_G0016807
protein coding gene Chr10:17287109-17299760 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017444
protein coding gene Chr10:17767901-17780584 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015149
protein coding gene Chr10:15697266-15710129 (+)
CAST/EiJ MGP_CASTEiJ_G0016389
protein coding gene Chr10:17165655-17177964 (+)
CBA/J MGP_CBAJ_G0016779
protein coding gene Chr10:18584382-18597041 (+)
DBA/2J MGP_DBA2J_G0016887
protein coding gene Chr10:16570229-16582888 (+)
FVB/NJ MGP_FVBNJ_G0016882
protein coding gene Chr10:16327070-16339753 (+)
LP/J MGP_LPJ_G0016962
protein coding gene Chr10:17153036-17165691 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016912
protein coding gene Chr10:18830882-18844621 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017482
protein coding gene Chr10:16951901-16964584 (+)
PWK/PhJ MGP_PWKPhJ_G0016174
protein coding gene Chr10:16441492-16453884 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015957
protein coding gene Chr10:17115364-17128214 (+)
WSB/EiJ MGP_WSBEiJ_G0016451
protein coding gene Chr10:17047188-17059849 (+)



Homology
more
  • Human Ortholog
    IL22RA2, interleukin 22 receptor subunit alpha 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IL22RA2, interleukin 22 receptor subunit alpha 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CRF2-10, CRF2-S1, CRF2X, IL-22BP, IL-22RA2, IL-22R-alpha-2, ZCYTOR16
  • Links
    NCBI Gene ID: 116379
    neXtProt AC: NX_Q969J5
    UniProt: Q969J5

  • Chr Location
    6q23.3; chr6:137143820-137173648 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display accelerated tumor formation in a colitis associated colon cancer model.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 237310 NCBI Gene Model | MGI Sequence Detail 12654 C57BL/6J ±  kb
transcript NM_178258 RefSeq | MGI Sequence Detail 2468 C57BL/6  
polypeptide Q80XF5 UniProt | EBI | MGI Sequence Detail 230 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 34
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:252646 Kleinschmidt D, et al., A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury. J Immunol. 2017 Dec 15;199(12):4078-4090

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory