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Cngb1
Gene Detail
 Symbol
Name
ID
Cngb1
cyclic nucleotide gated channel beta 1
MGI:2664102
Synonyms BC016201, Cngb1, Cngb1b, MGC:27656
Feature Type protein coding gene
Genetic Map
Chromosome 8
47.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:95239045-95306585 bp, - strand
From VEGA annotation of GRCm38

  67541 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:993  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

Protein SuperFamily: cyclic nucleotide-gated cation channel, beta subunit
Gene Tree: Cngb1

Human
homologs
Human Homolog CNGB1, cyclic nucleotide gated channel beta 1
NCBI Gene ID 1258
neXtProt AC  NX_Q14028
Human Synonyms  CNCG2, CNCG3L, CNCG4, CNG4, CNGB1B, GAR1, GARP, GARP2, RCNC2, RCNCb, RCNCbeta, RP45
Human Chr (Location)  16q13; chr16:57882340-57979251 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CNGB1
Alleles
and
phenotypes
All alleles(9) : Targeted(6) Gene trapped(3)
 
Homozygous null mice display postnatal lethality, reduced body size and weight, and retinal rod degeneration followed by cone degeneration. Mice homozygous for an allele lacking the calmodulin-binding domain exhibit defective olfactory neural signaling.
 
Human Diseases Modeled Using Mouse Cngb1 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cation transport, cytosolic calcium ion homeostasis, ...
Component integral component of plasma membrane, intracellular cyclic nucleotide activated cation channel complex, ...
Function cGMP binding, cyclic nucleotide-gated ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (148)    Tissues (19)    Images (49)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 148
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031171 (Evidence)
Ensembl Gene ModelENSMUSG00000031789 (Evidence)
Entrez Gene333329 (Evidence)
DFCITC1584929, TC1597366, TC1603442
DoTSDT.101262613, DT.101724502, DT.101724503, DT.40143525, DT.91334911
NIA Mouse Gene IndexU030132, U251980
Consensus CDS ProjectCCDS52641.1
International Mouse Knockout Project StatusCngb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031171 VEGA Gene Model | MGI Sequence Detail 67541 C57BL/6J ±  kb
transcript OTTMUST00000077236 VEGA | MGI Sequence Detail 6189 Not Applicable 
polypeptide OTTMUSP00000040800 VEGA | MGI Sequence Detail 1325 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(7) UniProt(6)
Polymorphisms SNPs within 2kb(460 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000005632 cyclic nucleotide-gated cation channel beta-1
References (Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:193199 Gilliam JC, et al., Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration. Cell. 2012 Nov 21;151(5):1029-41
All references(40)
Other
accession IDs
MGI:2385303, MGI:3037817

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory