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Cngb1 Gene Detail
Summary
  • Symbol
    Cngb1
  • Name
    cyclic nucleotide gated channel beta 1
  • Synonyms
    BC016201, Cngb1, Cngb1b, MGC:27656
  • Feature Type
    protein coding gene
  • IDs
    MGI:2664102
    NCBI Gene: 333329
  • Gene Overview
    MyGene.info: CNGB1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:95239045-95306585 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 47.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    449 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2664102
protein coding gene Chr8:95239043-95306585 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033981
protein coding gene Chr8:96712844-96787041 (-)
A/J MGP_AJ_G0033964
protein coding gene Chr8:92930021-92999883 (-)
AKR/J MGP_AKRJ_G0033890
protein coding gene Chr8:95454398-95525008 (-)
BALB/cJ MGP_BALBcJ_G0033956
protein coding gene Chr8:93005411-93077768 (-)
C3H/HeJ MGP_C3HHeJ_G0033666
protein coding gene Chr8:96187283-96258256 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034477
protein coding gene Chr8:100240493-100314661 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031418
protein coding gene Chr8:86727314-86796759 (-)
CAST/EiJ MGP_CASTEiJ_G0032998
protein coding gene Chr8:95777901-95847969 (-)
CBA/J MGP_CBAJ_G0033642
protein coding gene Chr8:103524518-103604903 (-)
DBA/2J MGP_DBA2J_G0033796
protein coding gene Chr8:92414596-92483953 (-)
FVB/NJ MGP_FVBNJ_G0033743
protein coding gene Chr8:91361261-91432218 (-)
LP/J MGP_LPJ_G0033888
protein coding gene Chr8:96846855-96916627 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033785
protein coding gene Chr8:105789475-105860485 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034495
protein coding gene Chr8:95623648-95703317 (-)
PWK/PhJ MGP_PWKPhJ_G0032700
protein coding gene Chr8:91773114-91845435 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032537
protein coding gene Chr8:94489622-94560433 (-)
WSB/EiJ MGP_WSBEiJ_G0033110
protein coding gene Chr8:96159013-96229207 (-)



Homology
more
  • Human Ortholog
    CNGB1, cyclic nucleotide gated channel beta 1
  • Vertebrate Orthologs
    3
  • Human Ortholog
    CNGB1, cyclic nucleotide gated channel beta 1
    Orthology source: HGNC
  • Synonyms
    CNCG2, CNCG3L, CNCG4, CNG4, CNGB1B, GAR1, GARP, GARP2, RCNC2, RCNCb, RCNCbeta, RP45
  • Links
    NCBI Gene ID: 1258
    neXtProt AC: NX_Q14028
    UniProt: Q14028

  • Chr Location
    16q21; chr16:57882340-57971116 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Cngb1 mouse models; 1 with human CNGB1 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 5 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display postnatal lethality, reduced body size and weight, and retinal rod degeneration followed by cone degeneration. Mice homozygous for an allele lacking the calmodulin-binding domain exhibit defective olfactory neural signaling.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031789 Ensembl Gene Model | MGI Sequence Detail 67541 C57BL/6J ±  kb
    transcript ENSMUST00000119870 Ensembl | MGI Sequence Detail 6189 Not Applicable  
    polypeptide ENSMUSP00000113827 Ensembl | MGI Sequence Detail 1325 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • InterPro Domains
      IPR018488 Cyclic nucleotide-binding, conserved site
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding-like
      IPR032944 Cyclic nucleotide-gated cation channel beta-1
      IPR014710 RmlC-like jelly roll fold
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2385303, MGI:3037817
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 2
      Diseases 2
      Gene Ontology 6
      Phenotypes 20
    • Earliest
      J:86879 Bradley J, et al., Nomenclature for ion channel subunits. Science. 2001 Dec 7;294(5549):2095-6
    • Latest
      J:258826 Petersen-Jones SM, et al., Patients and animal models of CNGbeta1-deficient retinitis pigmentosa support gene augmentation approach. J Clin Invest. 2018 Jan 2;128(1):190-206

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory