Cngb1
Gene Detail

Symbol Name ID

Cngb1 cyclic nucleotide gated channel beta 1 MGI:2664102

Synonyms

BC016201, Cngb1, Cngb1b, MGC:27656

Feature Type

protein coding gene

Genetic Map

Chromosome 8

47.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:95239043-95306585 bp, - strand From NCBI annotation of GRCm38   67543 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:993  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

Protein SuperFamily: cyclic nucleotide-gated cation channel, beta subunit

Human homologs

Human Homolog		CNGB1, cyclic nucleotide gated channel beta 1
NCBI Gene ID		1258
neXtProt AC		NX_Q14028
Human Synonyms		CNCG2, CNCG3L, CNCG4, CNG4, CNGB1B, GAR1, GARP, RCNC2, RCNCb, RCNCbeta, RP45
Human Chr (Location)		16q13; chr16:57916244-58005020 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CNGB1

Alleles and phenotypes

All alleles(9) : Targeted(6) Gene trapped(3)
 

Homozygous null mice display postnatal lethality, reduced body size and weight, and retinal rod degeneration followed by cone degeneration. Mice homozygous for an allele lacking the calmodulin-binding domain exhibit defective olfactory neural signaling.

 
Human Diseases Modeled Using Mouse Cngb1 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cytosolic calcium ion homeostasis, ion transmembrane transport, ...
Component	intracellular cyclic nucleotide activated cation channel complex, membrane, ...
Function	cyclic nucleotide-gated ion channel activity, intracellular cAMP activated cation channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (148)    Tissues (19)    Images (49)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	148

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(22)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000031171 (Evidence), OTTMUSG00000033644 (Evidence)
Ensembl Gene Model	ENSMUSG00000031789 (Evidence), ENSMUSG00000058253 (Evidence)
Entrez Gene	333329 (Evidence)
UniGene	484049
DFCI	TC1584929, TC1597366, TC1603442
DoTS	DT.101262613, DT.101724502, DT.101724503, DT.40143525, DT.91334911
NIA Mouse Gene Index	U030132, U251980
Consensus CDS Project	CCDS52641.1
International Mouse Knockout Project Status	Cngb1

Sequences

Length	Strain/Species
genomic	333329	NCBI Gene Model | MGI Sequence Detail	67543	C57BL/6J
transcript	NM_001195413	RefSeq | MGI Sequence Detail	6201	Not Specified
polypeptide	NP_001182342	RefSeq | MGI Sequence Detail	1325	Not Specified

All sequences(54) RefSeq(5) UniProt(5)

Protein-related information

Resource	ID	Description
InterPro	IPR018488	Cyclic nucleotide-binding, conserved site
InterPro	IPR000595	Cyclic nucleotide-binding domain
InterPro	IPR018490	Cyclic nucleotide-binding-like
InterPro	IPR014710	RmlC-like jelly roll fold
Protein Ontology	PR:000005632	cyclic nucleotide-gated cation channel beta-1

References

(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:193199 Gilliam JC, et al., Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration. Cell. 2012 Nov 21;151(5):1029-41
All references(40)

Other accession IDs

MGI:2385303, MGI:3037817