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Mogat2
Gene Detail
Symbol

Name
ID
Mogat2
monoacylglycerol O-acyltransferase 2
MGI:2663253
Synonyms
DGAT2L5, Mgat2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
54.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:99219084-99238619 bp, - strand
From VEGA annotation of GRCm38

  19536 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:57020  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 2-acylglycerol O-acyltransferase 1
Gene Tree: Mogat2

Human
homologs
Human Homolog MOGAT2, monoacylglycerol O-acyltransferase 2
NCBI Gene ID 80168
neXtProt AC  NX_Q3SYC2
Human Synonyms  DGAT2L5, MGAT2
Human Chr (Location)  11q13.5; chr11:75717889-75731286 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit resistance to diet induced obesity, hyperinsulinemia, hyperlipidemia, and steatosis with decreased lipid absorption and increased oxygen consumption when fed a high fat diet.
 
Interactions
Mogat2 interacts with 102 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (147)    Tissues (146)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 147
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(20) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000027299 (Evidence)
Ensembl Gene ModelENSMUSG00000052396 (Evidence)
Entrez Gene233549 (Evidence)
UniGene208030
DFCITC1583488
DoTSDT.97355280, DT.97347898
NIA Mouse Gene IndexU028892
EC2.3.1.22
Consensus CDS ProjectCCDS21478.1
International Mouse Knockout Project StatusMogat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027299 VEGA Gene Model | MGI Sequence Detail 19536 C57BL/6J ±  kb
transcript OTTMUST00000067475 VEGA | MGI Sequence Detail 1780 Not Applicable 
polypeptide OTTMUSP00000033961 VEGA | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(267 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007130 Diacylglycerol acyltransferase
Protein Ontology PR:000010516 2-acylglycerol O-acyltransferase 2
References
(Earliest) J:82922 Cao J, et al., Cloning and Functional Characterization of a Mouse Intestinal Acyl-CoA:Monoacylglycerol Acyltransferase, MGAT2. J Biol Chem. 2003 Apr 18;278(16):13860-6
(Latest) J:197907 Gao Y, et al., Intestine-specific expression of MOGAT2 partially restores metabolic efficiency in Mogat2-deficient mice. J Lipid Res. 2013 Jun;54(6):1644-52
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory