Mgat4a MGI Mouse Gene Detail - MGI:2662992 - mannoside acetylglucosaminyltransferase 4, isoenzyme A

Mgat4a Gene Detail

Symbol

Mgat4a
Name

mannoside acetylglucosaminyltransferase 4, isoenzyme A
Synonyms

9530018I07Rik, GnT-IVa

Feature Type

protein coding gene
IDs

MGI:2662992
NCBI Gene: 269181
Alliance

gene page

Sequence Map

Chr1:37439340-37541016 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

101677 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 15.46 cM
Mapping Data

2 experiments

Human Ortholog

MGAT4A, mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A

Vertebrate Orthologs

9

Human Ortholog

MGAT4A, mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
Orthology source: HomoloGene, HGNC
Synonyms

GnT-4a, GNT-IV, GNT-IVA
Links

HGNC:7047

NCBI Gene ID: 11320

neXtProt AC: NX_Q9UM21

UniProt: Q9UM21
Chr Location

2q11.2; chr2:98619106-98731126 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8153
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: MGAT4A
Gene Tree

Mgat4a

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Gene trapped

3
Targeted

2
Genomic Mutations

1 involving Mgat4a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available

Mice homozygous for a knock-out allele show defects in glucose-stimulated insulin secretion, impaired cellular glucose import, increased susceptibility to weight gain, hyperglycemia, impaired glucose tolerance, insulin resistance, high free fatty acid and triglyceride levels, and hepatic steatosis.

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All GO Annotations

13
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

94
Tissues

94
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mgat4a

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Mgat4a interacts with 476 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

70
RefSeq

22
UniProt

4
CCDS

CCDS14893.1, CCDS69882.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000033899	VEGA Gene Model \| MGI Sequence Detail	101677	C57BL/6J	± kb
transcript	OTTMUST00000085506	VEGA \| MGI Sequence Detail	7251	Not Applicable
polypeptide	OTTMUSP00000046192	VEGA \| MGI Sequence Detail	535	Not Applicable

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SNPs within 2kb

924 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000010381 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

(term hierarchy)
EC

2.4.1.145
InterPro Domains

IPR006759 Glycosyl transferase family 54

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 5

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MGI:2443457

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 7
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:217242 Kurimoto A, et al., The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function. J Biol Chem. 2014 Apr 25;289(17):11704-14

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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