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Ctnna3
Gene Detail
 Symbol
Name
ID
Ctnna3
catenin (cadherin associated protein), alpha 3
MGI:2661445
Synonyms 4930429L08Rik, alphaT-catenin, Catna3, Vr22
Feature Type protein coding gene
Genetic Map
Chromosome 10
32.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:63430098-65003667 bp, + strand
From VEGA annotation of GRCm38

  1573570 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56583  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: alpha-catenin
Gene Tree: Ctnna3

Human
homologs
Human Homolog CTNNA3, catenin (cadherin-associated protein), alpha 3
NCBI Gene ID 29119
neXtProt AC  NX_Q9UI47
Human Synonyms  ARVD13, VR22
Human Chr (Location)  10q22.2; chr10:65912518-67696191 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CTNNA3
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased heart weight, increased ventricle size, dilated cardiomyopathy and increased susceptibility to ischemia-induced arrhythmias and mortality.
 
Interactions
Ctnna3 interacts with 147 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell adhesion, single organismal cell-cell adhesion
Component adherens junction, cytoplasm, ...
Function actin filament binding, cadherin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000023790 (Evidence)
Ensembl Gene ModelENSMUSG00000060843 (Evidence)
Entrez Gene216033 (Evidence)
UniGene444692
DFCITC1588273, TC1600813, TC1611349, TC1705933
DoTSDT.55183073, DT.55188731, DT.55221176, DT.55265407, DT.91335188, DT.91445155, DT.91582738
NIA Mouse Gene IndexU011599, U352261
Consensus CDS ProjectCCDS23901.1
International Mouse Knockout Project StatusCtnna3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023790 VEGA Gene Model | MGI Sequence Detail 1573570 C57BL/6J ±  kb
transcript OTTMUST00000058129 VEGA | MGI Sequence Detail 2907 Not Applicable 
polypeptide OTTMUSP00000028119 VEGA | MGI Sequence Detail 895 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(12) UniProt(4)
Polymorphisms SNPs within 2kb(6150 from dbSNP Build 137)    SNPs within 2kb including multiple locations(6152)
Protein-related
information
ResourceIDDescription
InterPro IPR001033 Alpha-catenin
InterPro IPR006077 Vinculin/alpha-catenin
Protein Ontology PR:000006008 catenin alpha-3
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194034 Mazahery AR, et al., Functional analysis of ectodermal beta-catenin during external genitalia formation. Congenit Anom (Kyoto). 2013 Mar;53(1):34-41
All references(45)
Other
accession IDs
MGI:1921103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory