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Ctnna3 Gene Detail
Summary
  • Symbol
    Ctnna3
  • Name
    catenin (cadherin associated protein), alpha 3
  • Synonyms
    4930429L08Rik, alphaT-catenin, Catna3, Vr22
  • Feature Type
    protein coding gene
  • IDs
    MGI:2661445
    NCBI Gene: 216033
Location & Maps
more
  • Sequence Map
    Chr10:63430098-65003667 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1573570 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CTNNA3, catenin alpha 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CTNNA3, catenin alpha 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARVD13, VR22
  • Links
    NCBI Gene ID: 29119
    neXtProt AC: NX_Q9UI47

  • Chr Location
    10q22.2; chr10:65912518-67763610 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CTNNA3 associations

Human Disease Mouse Models
       Arrhythmogenic Right Ventricular Dysplasia, Familial, 13; ARVD13   OMIM: 615616
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Ctnna3
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased heart weight, increased ventricle size, dilated cardiomyopathy and increased susceptibility to ischemia-induced arrhythmias and mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023790 VEGA Gene Model | MGI Sequence Detail 1573570 C57BL/6J ±  kb
transcript OTTMUST00000058129 VEGA | MGI Sequence Detail 2907 Not Applicable  
polypeptide OTTMUSP00000028119 VEGA | MGI Sequence Detail 895 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    6150 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 5
Other
Accession IDs
less
MGI:1921103
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:194034 Mazahery AR, et al., Functional analysis of ectodermal beta-catenin during external genitalia formation. Congenit Anom (Kyoto). 2013 Mar;53(1):34-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory