Ctnna3
Gene Detail

Symbol

Name
ID

Ctnna3
catenin (cadherin associated protein), alpha 3
MGI:2661445

Synonyms

4930429L08Rik, alphaT-catenin, Catna3, Vr22

Feature Type

protein coding gene

Genetic Map

Chromosome 10
32.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:63430098-65003667 bp, + strand From VEGA annotation of GRCm38   1573570 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:56583  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: alpha-catenin
Gene Tree: Ctnna3

Human
homologs

Human Homolog		CTNNA3, catenin (cadherin-associated protein), alpha 3
NCBI Gene ID		29119
neXtProt AC		NX_Q9UI47
Human Synonyms		ARVD13, VR22
Human Chr (Location)		10q22.2; chr10:65912518-67696191 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human CTNNA3

Mutations,
alleles, and
phenotypes

All mutations/alleles(11) : Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit increased heart weight, increased ventricle size, dilated cardiomyopathy and increased susceptibility to ischemia-induced arrhythmias and mortality.

 

Interactions

Ctnna3 interacts with 147 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (14 annotations)

Process	cell adhesion, single organismal cell-cell adhesion
Component	adherens junction, cytoplasm, ...
Function	actin filament binding, cadherin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)

cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(13) cDNA(13)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000023790 (Evidence)
Ensembl Gene Model	ENSMUSG00000060843 (Evidence)
Entrez Gene	216033 (Evidence)
UniGene	444692
DFCI	TC1600813, TC1588273, TC1705933, TC1611349
DoTS	DT.55188731, DT.55183073, DT.55221176, DT.55265407, DT.91335188, DT.91582738, DT.91445155
NIA Mouse Gene Index	U352261, U011599
Consensus CDS Project	CCDS23901.1
International Mouse Knockout Project Status	Ctnna3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023790	VEGA Gene Model | MGI Sequence Detail	1573570	C57BL/6J
transcript	OTTMUST00000058130	VEGA | MGI Sequence Detail	3682	Not Applicable
polypeptide	OTTMUSP00000028120	VEGA | MGI Sequence Detail	895	Not Applicable

All sequences(59) RefSeq(12) UniProt(4)

Polymorphisms

SNPs within 2kb(6150 from dbSNP Build 137)    SNPs within 2kb including multiple locations(6152)

Protein-related
information

Resource	ID	Description
InterPro	IPR001033	Alpha-catenin
InterPro	IPR006077	Vinculin/alpha-catenin
Protein Ontology	PR:000006008	catenin alpha-3

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194034 Mazahery AR, et al., Functional analysis of ectodermal beta-catenin during external genitalia formation. Congenit Anom (Kyoto). 2013 Mar;53(1):34-41
All references(45)

Other
accession IDs

MGI:1921103