Ctnna3 Gene Detail

Summary

• Symbol
  Ctnna3
• Name
  catenin (cadherin associated protein), alpha 3
• Synonyms
  4930429L08Rik, alphaT-catenin, Catna3, Vr22

• Feature Type
  protein coding gene
• IDs
  MGI:2661445
  NCBI Gene: 216033

Location & Maps

• Sequence Map
  Chr10:63430098-65003667 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    1573570 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 10, 32.57 cM
• Mapping Data
  3 experiments

Homology

• Human Ortholog
  CTNNA3, catenin alpha 3

• Vertebrate Orthologs
  8

• Human Ortholog
  CTNNA3, catenin alpha 3
  Orthology source: HomoloGene, HGNC
• Synonyms
  ARVD13, VR22
• Links
  HGNC:2511

  NCBI Gene ID: 29119

  neXtProt AC: NX_Q9UI47

  
  
• Chr Location
  10q22.2; chr10:65912518-67763610 (-)  GRCh38.p2

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• HomoloGene
  Vertebrate Homology Class 56583
  1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken
  
• HCOP
  human homology predictions: CTNNA3
• Protein SuperFamily
  alpha-catenin
• Gene Tree
  Ctnna3
  

Human Diseases

• Diseases
  1 with human CTNNA3 associations

				Human Disease	Mouse Models
				Arrhythmogenic Right Ventricular Dysplasia, Familial, 13; ARVD13   OMIM: 615616

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  12 phenotypes from 2 alleles in 2 genetic backgrounds
  13 phenotype references
  

• All Mutations and Alleles
  13
• Chemically induced (other)
  1
• Gene trapped
  5
• Radiation induced
  1
• Targeted
  6
• Genomic Mutations
  2 involving Ctnna3
• Incidental Mutations
  Mutagenetix , APF , CvDC

Mice homozygous for a knock-out allele exhibit increased heart weight, increased ventricle size, dilated cardiomyopathy and increased susceptibility to ischemia-induced arrhythmias and mortality.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  19
• GO References
  7

• External Resources
  FuncBase

Expression

• cDNA Data
  14
• Literature Summary
  2

• Other Mouse Links
  Allen Institute
  GEO

Interactions

• Ctnna3 interacts with 147 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

Sequences &
Gene Models

• All Sequences
  44
• RefSeq
  8
• UniProt
  4
• CCDS
  CCDS23901.1
• UniGene
  444692

• VEGA
  OTTMUSG00000023790 (Evidence)
• Ensembl
  ENSMUSG00000060843 (Evidence)
• NCBI Gene
  216033

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000023790	VEGA Gene Model | MGI Sequence Detail	1573570	C57BL/6J
transcript	OTTMUST00000058129	VEGA | MGI Sequence Detail	2907	Not Applicable
polypeptide	OTTMUSP00000028119	VEGA | MGI Sequence Detail	895	Not Applicable

Polymorphisms

• SNPs within 2kb
  6131 from dbSNP Build 142

Protein
Information

• UniProt
  4 Sequences
• Protein Ontology
  PR:000006008 catenin alpha-3
• InterPro Domains
  IPR001033 Alpha-catenin
  IPR030044 Alpha T-catenin
  IPR006077 Vinculin/alpha-catenin

Molecular
Reagents

• All nucleic 14

  cDNA 14

  
  

  Microarray probesets 5

Other
Accession IDs

MGI:1921103

References

• Summaries
  All 40

  Developmental Gene Expression 2

  Gene Ontology 7

  Phenotypes 13
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:227949 Folmsbee SS, et al., The cardiac protein alphaT-catenin contributes to chemical-induced asthma. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 1;308(3):L253-8