Ctnna3 MGI Mouse Gene Detail - MGI:2661445 - catenin (cadherin associated protein), alpha 3

Ctnna3 Gene Detail

Symbol

Ctnna3
Name

catenin (cadherin associated protein), alpha 3
Synonyms

4930429L08Rik, alphaT-catenin, Catna3, Vr22

Feature Type

protein coding gene
IDs

MGI:2661445
NCBI Gene: 216033
Alliance

gene page

Sequence Map

Chr10:63430098-65003667 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

1573570 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 32.57 cM
Mapping Data

3 experiments

Human Ortholog

CTNNA3, catenin alpha 3

Vertebrate Orthologs

8

Human Ortholog

CTNNA3, catenin alpha 3
Orthology source: HomoloGene, HGNC
Synonyms

ARVD13, VR22
Links

HGNC:2511

NCBI Gene ID: 29119

neXtProt AC: NX_Q9UI47

UniProt: Q9UI47
Chr Location

10q21.3; chr10:65912518-67696217 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56583
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 macaque, rhesus
HCOP

human homology predictions: CTNNA3
Protein SuperFamily

alpha-catenin
Gene Tree

Ctnna3

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Gene trapped

5
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Ctnna3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available

Mice homozygous for a knock-out allele exhibit increased heart weight, increased ventricle size, dilated cardiomyopathy and increased susceptibility to ischemia-induced arrhythmias and mortality.

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All GO Annotations

19
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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cDNA Data

14
Literature Summary

3

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Ctnna3 interacts with 147 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

44
RefSeq

8
UniProt

4
CCDS

CCDS23901.1
UniGene

444692

			Length	Strain/Species	Flank
genomic	OTTMUSG00000023790	VEGA Gene Model \| MGI Sequence Detail	1573570	C57BL/6J	± kb
transcript	OTTMUST00000058129	VEGA \| MGI Sequence Detail	2907	Not Applicable
polypeptide	OTTMUSP00000028119	VEGA \| MGI Sequence Detail	895	Not Applicable

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SNPs within 2kb

6131 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000006008 catenin alpha-3

(term hierarchy)
InterPro Domains

IPR001033 Alpha-catenin

IPR030044 Alpha T-catenin

IPR006077 Vinculin/alpha-catenin

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All nucleic 14

cDNA 14

Microarray probesets 5

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MGI:1921103

Summaries

All 47

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:238422 Fumoto K, et al., Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition. Development. 2017 Jan 01;144(1):151-162

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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