Ctnna3 MGI Mouse Gene Detail - MGI:2661445 - catenin (cadherin associated protein), alpha 3

Symbol

Ctnna3
Name

catenin (cadherin associated protein), alpha 3
Synonyms

4930429L08Rik, alphaT-catenin, Catna3, Vr22

Feature Type

protein coding gene
IDs

MGI:2661445
NCBI Gene: 216033
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:63430098-65003667 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 32.57 cM
Mapping Data

3 experiments

SNPs within 2kb

6131 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2661445	protein coding gene	Chr10:63430098-65003667 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017318	protein coding gene	Chr10:62962839-64607564 (+)
A/J	MGP_AJ_G0017295	protein coding gene	Chr10:60985446-62549372 (+)
AKR/J	MGP_AKRJ_G0017256	protein coding gene	Chr10:62603141-64246015 (+)
BALB/cJ	MGP_BALBcJ_G0017255	protein coding gene	Chr10:61092537-62663614 (+)
C3H/HeJ	MGP_C3HHeJ_G0017079	protein coding gene	Chr10:62527065-64167825 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017713	protein coding gene	Chr10:65226581-66927177 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015403	protein coding gene	Chr10:57899710-59368058 (+)
CAST/EiJ	MGP_CASTEiJ_G0016649	protein coding gene	Chr10:62594829-64242206 (+)
CBA/J	MGP_CBAJ_G0017051	protein coding gene	Chr10:67706440-69517272 (+)
DBA/2J	MGP_DBA2J_G0017156	protein coding gene	Chr10:60255894-61845418 (+)
FVB/NJ	MGP_FVBNJ_G0017149	protein coding gene	Chr10:59525209-61090245 (+)
LP/J	MGP_LPJ_G0017229	protein coding gene	Chr10:63368494-65029104 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017177	protein coding gene	Chr10:69833270-71595620 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017752	protein coding gene	Chr10:62438377-64094148 (+)
PWK/PhJ	MGP_PWKPhJ_G0016433	protein coding gene	Chr10:60138907-61701763 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016215	protein coding gene	Chr10:61776550-63396742 (+)
WSB/EiJ	MGP_WSBEiJ_G0016713	protein coding gene	Chr10:62409231-64030735 (+)

Human Ortholog

CTNNA3, catenin alpha 3

Vertebrate Orthologs

8

Human Ortholog

CTNNA3, catenin alpha 3
Orthology source: HomoloGene, HGNC
Synonyms

ARVD13, VR22
Links

HGNC:2511

NCBI Gene ID: 29119

neXtProt AC: NX_Q9UI47

UniProt: Q9UI47
Chr Location

10q21.3; chr10:65912518-67696217 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56583
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 macaque, rhesus
HCOP

human homology predictions: CTNNA3
Protein SuperFamily

alpha-catenin
Gene Tree

Ctnna3

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Gene trapped

5
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Ctnna3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased heart weight, increased ventricle size, dilated cardiomyopathy and increased susceptibility to ischemia-induced arrhythmias and mortality.

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All GO Annotations

18
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

2
Tissues

1
cDNA Data

15
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Ctnna3 interacts with 147 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

55
RefSeq

8
UniProt

4
CCDS

CCDS23901.1
UniGene

444692

Ensembl

ENSMUSG00000060843 (Evidence)
NCBI Gene

216033

			Length	Strain/Species	Flank
genomic	216033	NCBI Gene Model \| MGI Sequence Detail	1573570	C57BL/6J	± kb
transcript	NM_001164376	RefSeq \| MGI Sequence Detail	3681	C57BL/6
polypeptide	Q65CL1	UniProt \| EBI \| MGI Sequence Detail	895	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006008 catenin alpha-3

(term hierarchy)
InterPro Domains

IPR001033 Alpha-catenin

IPR036723 Alpha-catenin/vinculin-like superfamily

IPR030044 Alpha T-catenin

IPR006077 Vinculin/alpha-catenin

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All nucleic 15

cDNA 15

Microarray probesets 5

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MGI:1921103

Summaries

All 51

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:260432 Vite A, et al., alpha-Catenin-dependent cytoskeletal tension controls Yap activity in the heart. Development. 2018 Mar 8;145(5)

TSS for Ctnna3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93762	Chr10:63430061-63430085 (+)	-25 bp
Tssr93763	Chr10:63430092-63430105 (+)	1 bp
Tssr93764	Chr10:63457505-63457539 (+)	27,424 bp
Tssr93765	Chr10:63457549-63457555 (+)	27,454 bp
Tssr93766	Chr10:63457578-63457583 (+)	27,483 bp
Tssr93774	Chr10:63821043-63821057 (+)	390,952 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/15/2019 MGI 6.14