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Ctnna3
Gene Detail
Symbol

Name
ID
Ctnna3
catenin (cadherin associated protein), alpha 3
MGI:2661445
Synonyms
4930429L08Rik, alphaT-catenin, Catna3, Vr22
Feature Type
protein coding gene
Genetic Map
Chromosome 10
32.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:63430098-65003667 bp, + strand
From VEGA annotation of GRCm38

  1573570 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56583  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: CTNNA3
Protein SuperFamily: alpha-catenin
Gene Tree: Ctnna3

Human
homologs
CTNNA3, catenin (cadherin-associated protein), alpha 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 29119
neXtProt AC: NX_Q9UI47

Human Synonyms: ARVD13, VR22

Human Chr (Location): 10q22.2; chr10:65912518-67763610 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CTNNA3

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit increased heart weight, increased ventricle size, dilated cardiomyopathy and increased susceptibility to ischemia-induced arrhythmias and mortality.
 
Interactions
Ctnna3 interacts with 147 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process bundle of His cell-Purkinje myocyte adhesion involved in cell communication, cell adhesion, ...
Component adherens junction, cytoplasm, ...
Function actin filament binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000023790 (Evidence)
Ensembl Gene Model ENSMUSG00000060843 (Evidence)
Entrez Gene 216033 (Evidence)
UniGene 444692
DFCI TC1705933, TC1611349, TC1600813, TC1588273
DoTS DT.91335188, DT.55188731, DT.55183073, DT.91445155, DT.55221176, DT.55265407, DT.91582738
NIA Mouse Gene Index U352261, U011599
Consensus CDS Project CCDS23901.1
International Mouse Phenotyping Consortium Status Ctnna3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023790 VEGA Gene Model | MGI Sequence Detail 1573570 C57BL/6J ±  kb
transcript OTTMUST00000058130 VEGA | MGI Sequence Detail 3682 Not Applicable 
polypeptide OTTMUSP00000028120 VEGA | MGI Sequence Detail 895 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(6150 from dbSNP Build 137)    SNPs within 2kb including multiple locations(6152)
Protein-related
information
ResourceIDDescription
InterPro IPR001033 Alpha-catenin
InterPro IPR006077 Vinculin/alpha-catenin
Protein Ontology PR:000006008 catenin alpha-3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194034 Mazahery AR, et al., Functional analysis of ectodermal beta-catenin during external genitalia formation. Congenit Anom (Kyoto). 2013 Mar;53(1):34-41
All references(43)
Other
accession IDs
MGI:1921103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory