Rtn4rl1
Gene Detail

Symbol Name ID

Rtn4rl1 reticulon 4 receptor-like 1 MGI:2661375

Synonyms

Ngr3, Ngrh2, Ngrl2

Feature Type

protein coding gene

Genetic Map

Chromosome 11

45.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:75193783-75267769 bp, + strand From VEGA annotation of GRCm38   73987 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Rtn4rl1 ± 2 cM)

Gene Tree: Rtn4rl1

Human ortholog

RTN4RL1 reticulon 4 receptor-like 1 NCBI Gene ID 146760
Human Synonyms: NgR3, NGRH2
Human Chr17:1837971-1928178 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)
 

Mice homozygous for disruptions in this gene display fatty change in the liver, bile duct lesions in females and hepatocytes with enlarged vacuoles and nuclei in the male.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	axon regeneration
Component	anchored to membrane, anchored to plasma membrane, ...
Function	receptor activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (109)    Tissues (69)   
Theiler Stages: 21, 23, 28

Assay Type	Results
RNA in situ	103
RT-PCR	6

cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(28) cDNA(25) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000006197 (Evidence)
Ensembl Gene Model	ENSMUSG00000045287 (Evidence)
Entrez Gene	237847 (Evidence)
UniGene	82661
DFCI	TC1582016
DoTS	DT.528996
NIA Mouse Gene Index	U012946
Consensus CDS Project	CCDS25043.1
International Mouse Knockout Project Status	Rtn4rl1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006197	VEGA Gene Model | MGI Sequence Detail	73987	C57BL/6J
transcript	OTTMUST00000013970	VEGA | MGI Sequence Detail	3525	Not Applicable
polypeptide	OTTMUSP00000006489	VEGA | MGI Sequence Detail	445	Not Applicable

All sequences(20) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(326 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000483	Cysteine-rich flanking region, C-terminal
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
Protein Ontology	PR:000014351	reticulon-4 receptor-like 1

References

(Earliest) J:83107 Pignot V, et al., Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. J Neurochem. 2003 May;85(3):717-28
(Latest) J:191258 Dickendesher TL, et al., NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat Neurosci. 2012 May;15(5):703-12
All references(36)

Other accession IDs

MGI:2669799