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Rtn4rl1
Gene Detail
 Symbol
Name
ID
Rtn4rl1
reticulon 4 receptor-like 1
MGI:2661375
Synonyms Ngr3, Ngrh2, Ngrl2
Feature Type protein coding gene
Genetic Map
Chromosome 11
45.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:75193783-75267769 bp, + strand
From VEGA annotation of GRCm38

  73987 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18611  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Rtn4rl1

Human
homologs
Human Homolog RTN4RL1, reticulon 4 receptor-like 1
NCBI Gene ID 146760
neXtProt AC  NX_Q86UN2
Human Synonyms  NgR3, NGRH2
Human Chr (Location)  17p13.3; chr17:1934677-2024884 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display fatty change in the liver, bile duct lesions in females and hepatocytes with enlarged vacuoles and nuclei in the male.
 
Interactions
Rtn4rl1 interacts with 244 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process axon regeneration
Component anchored component of membrane, anchored component of plasma membrane, ...
Function receptor activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (109)    Tissues (69)   
Theiler Stages: 21, 23, 28
Assay TypeResults
RNA in situ 103
RT-PCR 6
cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(24) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006197 (Evidence)
Ensembl Gene ModelENSMUSG00000045287 (Evidence)
Entrez Gene237847 (Evidence)
UniGene82661
DFCITC1582016
DoTSDT.528996
NIA Mouse Gene IndexU012946
Consensus CDS ProjectCCDS25043.1
International Mouse Knockout Project StatusRtn4rl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006197 VEGA Gene Model | MGI Sequence Detail 73987 C57BL/6J ±  kb
transcript OTTMUST00000013970 VEGA | MGI Sequence Detail 3525 Not Applicable 
polypeptide OTTMUSP00000006489 VEGA | MGI Sequence Detail 445 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(389 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000014351 reticulon-4 receptor-like 1
References (Earliest) J:83107 Pignot V, et al., Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. J Neurochem. 2003 May;85(3):717-28
(Latest) J:191258 Dickendesher TL, et al., NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat Neurosci. 2012 May;15(5):703-12
All references(36)
Other
accession IDs
MGI:2669799

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory