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Neu4
Gene Detail
Symbol

Name
ID
Neu4
sialidase 4
MGI:2661364
Feature Type
protein coding gene
Genetic Map
Chromosome 1
47.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:94020451-94028334 bp, + strand
From VEGA annotation of GRCm38

  7884 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15433  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Neu4

Human
homologs
Human Homolog NEU4, sialidase 4
NCBI Gene ID 129807
neXtProt AC  NX_Q8WWR8
Human Chr (Location)  2q37.3; chr2:241809065-241817413 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele are largely normal except increased lipid content in the lung and liver and vacuolization indicative of lysosomal storage disorder.
 
Interactions
Neu4 interacts with 317 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process carbohydrate metabolic process, ganglioside catabolic process, ...
Component membrane, mitochondrion, ...
Function exo-alpha-(2->3)-sialidase activity, exo-alpha-(2->6)-sialidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (101)    Tissues (100)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 7
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000048695 (Evidence)
Ensembl Gene ModelENSMUSG00000034000 (Evidence)
Entrez Gene241159 (Evidence)
UniGene214565
DFCITC1609662, TC1587344
DoTSDT.102552581, DT.101365146
EC3.2.1.18
Consensus CDS ProjectCCDS15199.1
International Mouse Knockout Project StatusNeu4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048695 VEGA Gene Model | MGI Sequence Detail 7884 C57BL/6J ±  kb
transcript OTTMUST00000124692 VEGA | MGI Sequence Detail 1719 Not Applicable 
polypeptide OTTMUSP00000067807 VEGA | MGI Sequence Detail 501 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026946 Sialidase-4
InterPro IPR026856 Sialidase family
InterPro IPR011040 Sialidases
Protein Ontology PR:000011148 sialidase-4
References
(Earliest) J:86819 Comelli EM, et al., Identification and expression of Neu4, a novel murine sialidase. Gene. 2003 Dec 4;321:155-61
(Latest) J:185058 Takahashi K, et al., Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons. J Biol Chem. 2012 Apr 27;287(18):14816-26
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory