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Mppe1 Gene Detail
Summary
  • Symbol
    Mppe1
  • Name
    metallophosphoesterase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2661311
    NCBI Gene: 225651
Location & Maps
more
  • Sequence Map
    Chr18:67225530-67245830 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20301 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 39.90 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MPPE1, metallophosphoesterase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MPPE1, metallophosphoesterase 1
    Orthology source: HomoloGene
  • Synonyms
    PGAP5
  • Links
    NCBI Gene ID: 65258
    neXtProt AC: NX_Q53F39

  • Chr Location
    18p11.21; chr18:11883471-11908797 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41512
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MPPE1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000062526 Ensembl Gene Model | MGI Sequence Detail 20301 C57BL/6J ±  kb
transcript ENSMUST00000073054 Ensembl | MGI Sequence Detail 2007 Not Applicable  
polypeptide ENSMUSP00000072808 Ensembl | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    142 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010548 metallophosphoesterase 1
  • EC
  • InterPro Domains
    IPR004843 Calcineurin-like phosphoesterase domain, apaH type
    IPR029052 Metallo-dependent phosphatase-like
    IPR033308 PGAP5/Cdc1/Ted1
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory