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Prss33
Gene Detail
Symbol

Name
ID
Prss33
protease, serine 33
MGI:2661234
Synonyms
Eos, mT6, tryptase-6
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.08 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:23833360-23836056 bp, - strand
From VEGA annotation of GRCm38

  2697 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77185  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

HCOP human homology predictions: PRSS33
Protein SuperFamily: trypsin
Gene Tree: Prss33

Human
homologs
PRSS33, protease, serine, 33
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 260429
neXtProt AC: NX_Q8NF86

Human Synonyms: EOS

Human Chr (Location): 16p13.3; chr16:2783953-2787607 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Prss33 interacts with 52 markers (Mir15a, Mir22, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process proteolysis
Component extracellular region, extracellular space
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (40)    Tissues (25)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
RT-PCR 20
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000035218 (Evidence)
Ensembl Gene Model ENSMUSG00000049620 (Evidence)
Entrez Gene 353130 (Evidence)
UniGene 261689
DFCI TC1591709
DoTS DT.110560692, DT.101358453, DT.91427700
NIA Mouse Gene Index U053847
EC 3.4.21.-
Consensus CDS Project CCDS37476.2
International Mouse Phenotyping Consortium Status Prss33
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035218 VEGA Gene Model | MGI Sequence Detail 2697 C57BL/6J ±  kb
transcript OTTMUST00000089733 VEGA | MGI Sequence Detail 1360 Not Applicable 
polypeptide OTTMUSP00000049073 VEGA | MGI Sequence Detail 277 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(5) UniProt(2)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000013326 serine protease 33
References
(Earliest) J:86752 Wong GW, et al., Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns. J Biol Chem. 2004 Jan 23;279(4):2438-52
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory