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Cnksr2 Gene Detail
Summary
  • Symbol
    Cnksr2
  • Name
    connector enhancer of kinase suppressor of Ras 2
  • Synonyms
    Cnk2, Ksr2, mKIAA0902
  • Feature Type
    protein coding gene
  • IDs
    MGI:2661175
    NCBI Gene: 245684
  • Gene Overview
    MyGene.info: CNKSR2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:157821573-158043353 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 72.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    666 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2661175
protein coding gene ChrX:157821436-158043353 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036222
protein coding gene ChrX:155712065-155950830 (-)
A/J MGP_AJ_G0036192
protein coding gene ChrX:155027526-155255340 (-)
AKR/J MGP_AKRJ_G0036120
protein coding gene ChrX:159923940-160156128 (-)
BALB/cJ MGP_BALBcJ_G0036185
protein coding gene ChrX:153083403-153307242 (-)
C3H/HeJ MGP_C3HHeJ_G0035891
protein coding gene ChrX:156071749-156313682 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036707
protein coding gene ChrX:160311812-160563383 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033528
protein coding gene ChrX:146359801-146598164 (-)
CAST/EiJ MGP_CASTEiJ_G0035179
protein coding gene ChrX:135172241-135442636 (-)
CBA/J MGP_CBAJ_G0035866
protein coding gene ChrX:164894441-165143504 (-)
DBA/2J MGP_DBA2J_G0036032
protein coding gene ChrX:154000323-154224585 (-)
FVB/NJ MGP_FVBNJ_G0035963
protein coding gene ChrX:153097932-153338071 (-)
LP/J MGP_LPJ_G0036117
protein coding gene ChrX:156870526-157107115 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035995
protein coding gene ChrX:173458637-173776804 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036748
protein coding gene ChrX:155263537-155503217 (-)
PWK/PhJ MGP_PWKPhJ_G0034877
protein coding gene ChrX:132120710-132346401 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034698
protein coding gene ChrX:135644432-135864651 (-)
WSB/EiJ MGP_WSBEiJ_G0035314
protein coding gene ChrX:153256105-153486693 (-)



Homology
more
  • Human Ortholog
    CNKSR2, connector enhancer of kinase suppressor of Ras 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CNKSR2, connector enhancer of kinase suppressor of Ras 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CNK2, KSR2, MAGUIN, MRXSHG
  • Links
    NCBI Gene ID: 22866
    neXtProt AC: NX_Q8WXI2
    UniProt: Q8WXI2

  • Chr Location
    Xp22.12; chrX:21374335-21654695 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8956
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CNKSR2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CNKSR2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 245684 NCBI Gene Model | MGI Sequence Detail 221781 C57BL/6J ±  kb
transcript NM_177751 RefSeq | MGI Sequence Detail 5521 C57BL/6  
polypeptide Q80YA9 UniProt | EBI | MGI Sequence Detail 1032 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
  • Latest
    J:249721 Li J, et al., Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Nat Neurosci. 2017 Aug;20(8):1150-1161

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory