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Acvr1c
Gene Detail
 Symbol
Name
ID
Acvr1c
activin A receptor, type IC
MGI:2661081
Synonyms Alk-7, ALK7
Feature Type protein coding gene
Genetic Map
Chromosome 2
33.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:58267453-58357895 bp, - strand
From VEGA annotation of GRCm38

  90443 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:26724  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: type I serine/threonine-protein kinase receptor, Activin/BMP/TGF-beta types
Gene Tree: Acvr1c

Human
homologs
Human Homolog ACVR1C, activin A receptor, type IC
NCBI Gene ID 130399
neXtProt AC  NX_Q8NER5
Human Synonyms  ACVRLK7, ALK7
Human Chr (Location)  2q24.1; chr2:157526767-157628887 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Homozygous null mice display normal growth, gut, skeleton, spleen, and cerebellum morphology, glucose and insulin levels, and left-right patterning.
 
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process activin receptor signaling pathway, apoptotic nuclear changes, ...
Component activin receptor complex, cell surface, ...
Function activin binding, activin receptor activity, type I, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (101)    Tissues (46)    Images (17)
Theiler Stages: 2, 3, 19, 23, 25, 28
Assay TypeResults
RNA in situ 63
RT-PCR 38
cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(10) cDNA(7) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000012673 (Evidence)
Ensembl Gene ModelENSMUSG00000026834 (Evidence)
Entrez Gene269275 (Evidence)
UniGene77751
DFCITC1599182, TC1636855
DoTSDT.40147962, DT.91356137, DT.94132612
NIA Mouse Gene IndexU022653
EC2.7.11.30
Consensus CDS ProjectCCDS16049.1, CCDS50586.1
International Mouse Knockout Project StatusAcvr1c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012673 VEGA Gene Model | MGI Sequence Detail 90443 C57BL/6J ±  kb
transcript OTTMUST00000030193 VEGA | MGI Sequence Detail 9162 Not Applicable 
polypeptide OTTMUSP00000013587 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(9) UniProt(6)
Polymorphisms SNPs within 2kb(453 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR000472 TGF-beta receptor/activin receptor, type I/II
InterPro IPR003605 TGF beta receptor, GS motif
Protein Ontology PR:000000069 activin receptor type-1C
References (Earliest) J:87407 Dudas M, et al., Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol. 2004 Feb 1;266(1):96-108
(Latest) J:195695 Miles DC, et al., Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development. PLoS One. 2013;8(1):e54606
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory