Acvr1c
Gene Detail

Symbol Name ID

Acvr1c activin A receptor, type IC MGI:2661081

Synonyms

Alk-7, ALK7

Feature Type

protein coding gene

Genetic Map

Chromosome 2

33.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:58267453-58357895 bp, - strand From VEGA annotation of GRCm38   90443 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:26724  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: type I serine/threonine-protein kinase receptor, Activin/BMP/TGF-beta types
Gene Tree: Acvr1c

Human homologs

Human Homolog		ACVR1C, activin A receptor, type IC
NCBI Gene ID		130399
neXtProt AC		NX_Q8NER5
Human Synonyms		ACVRLK7, ALK7
Human Chr (Location)		2q24.1; chr2:158383279-158485399 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null mice display normal growth, gut, skeleton, spleen, and cerebellum morphology, glucose and insulin levels, and left-right patterning.

 

Gene Ontology (GO) classifications

All GO classifications: (49 annotations)

Process	apoptotic process, cell differentiation, ...
Component	activin receptor complex, cell surface, ...
Function	activin binding, activin receptor activity, type I, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (101)    Tissues (46)    Images (17)
Theiler Stages: 2, 3, 19, 23, 25, 28

Assay Type	Results
RNA in situ	63
RT-PCR	38

cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(7) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000012673 (Evidence)
Ensembl Gene Model	ENSMUSG00000026834 (Evidence)
Entrez Gene	269275 (Evidence)
UniGene	77751
DFCI	TC1599182, TC1636855
DoTS	DT.40147962, DT.91356137, DT.94132612
NIA Mouse Gene Index	U022653
EC	2.7.11.30
Consensus CDS Project	CCDS16049.1, CCDS50586.1
International Mouse Knockout Project Status	Acvr1c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012673	VEGA Gene Model | MGI Sequence Detail	90443	C57BL/6J
transcript	OTTMUST00000030193	VEGA | MGI Sequence Detail	9162	Not Applicable
polypeptide	OTTMUSP00000013587	VEGA | MGI Sequence Detail	493	Not Applicable

All sequences(47) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(279 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
InterPro	IPR000472	TGF-beta receptor/activin receptor, type I/II
InterPro	IPR003605	TGF beta receptor, GS motif
Protein Ontology	PR:000000069	activin receptor type-1C

References

(Earliest) J:87407 Dudas M, et al., Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol. 2004 Feb 1;266(1):96-108
(Latest) J:193340 Sandoval-Guzman T, et al., Neuroendocrine control of female reproductive function by the activin receptor ALK7. FASEB J. 2012 Dec;26(12):4966-76
All references(45)