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Acvr1c Gene Detail
Summary
  • Symbol
    Acvr1c
  • Name
    activin A receptor, type IC
  • Synonyms
    Alk-7, ALK7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2661081
    NCBI Gene: 269275
  • Gene Overview
    MyGene.info: ACVR1C
Location & Maps
more
  • Sequence Map
    Chr2:58267453-58357895 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      90443 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ACVR1C, activin A receptor type 1C
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ACVR1C, activin A receptor type 1C
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACVRLK7, ALK7
  • Links
    NCBI Gene ID: 130399
    neXtProt AC: NX_Q8NER5

  • Chr Location
    2q24.1; chr2:157526767-157628887 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    10 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Acvr1c
  • Incidental Mutations
Mice homozygous for a knock-out allele are viable, fertile, and overtly normal with no apparent left-right patterning abnormalities or organogenesis defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012673 VEGA Gene Model | MGI Sequence Detail 90443 C57BL/6J ±  kb
transcript OTTMUST00000030193 VEGA | MGI Sequence Detail 9162 Not Applicable  
polypeptide OTTMUSP00000013587 VEGA | MGI Sequence Detail 493 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    453 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 7
    Primer pair 2
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 43
    Developmental Gene Expression 10
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:87407 Dudas M, et al., Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol. 2004 Feb 1;266(1):96-108
  • Latest
    J:214959 Lodato S, et al., Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014 Aug;17(8):1046-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory