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Acvr1c
Gene Detail
Symbol

Name
ID
Acvr1c
activin A receptor, type IC
MGI:2661081
Synonyms
Alk-7, ALK7
Feature Type
protein coding gene
Genetic Map
Chromosome 2
33.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:58267453-58357895 bp, - strand
From VEGA annotation of GRCm38

  90443 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:26724  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: ACVR1C
Protein SuperFamily: type I serine/threonine-protein kinase receptor, Activin/BMP/TGF-beta types
Gene Tree: Acvr1c

Human
homologs
ACVR1C, activin A receptor, type IC
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 130399
neXtProt AC: NX_Q8NER5

Human Synonyms: ACVRLK7, ALK7

Human Chr (Location): 2q24.1; chr2:157526767-157628887 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Acvr1c interacts with 513 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process activin receptor signaling pathway, apoptotic nuclear changes, ...
Component activin receptor complex, cell surface, ...
Function activin binding, activin receptor activity, type I, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (101)    Tissues (46)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 63
RT-PCR 38
cDNA source data(7)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase acvr1c    NEW 
Molecular
reagents
All nucleic(10) cDNA(7) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000012673 (Evidence)
Ensembl Gene Model ENSMUSG00000026834 (Evidence)
Entrez Gene 269275 (Evidence)
UniGene 77751
DFCI TC1599182, TC1636855
DoTS DT.40147962, DT.91356137, DT.94132612
NIA Mouse Gene Index U022653
EC 2.7.11.30
Consensus CDS Project CCDS16049.1, CCDS50586.1
International Mouse Phenotyping Consortium Status Acvr1c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012673 VEGA Gene Model | MGI Sequence Detail 90443 C57BL/6J ±  kb
transcript OTTMUST00000030193 VEGA | MGI Sequence Detail 9162 Not Applicable 
polypeptide OTTMUSP00000013587 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(11) UniProt(6)
Polymorphisms
SNPs within 2kb(453 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000333 Activin type II/Transforming growth factor-beta II receptor
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR000472 TGF-beta receptor/activin receptor, type I/II
InterPro IPR003605 TGF beta receptor, GS motif
Protein Ontology PR:000000069 activin receptor type-1C
References
(Earliest) J:87407 Dudas M, et al., Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol. 2004 Feb 1;266(1):96-108
(Latest) J:214959 Lodato S, et al., Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014 Aug;17(8):1046-54
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory