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Gmppb
Gene Detail
Symbol

Name
ID
Gmppb
GDP-mannose pyrophosphorylase B
MGI:2660880
Feature Type
protein coding gene
Genetic Map
Chromosome 9
59.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:108049242-108052801 bp, + strand
From VEGA annotation of GRCm38

  3560 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5578  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GMPPB
Protein SuperFamily: mannose-1-phosphate guanylyltransferase
Gene Tree: Gmppb

Human
homologs
GMPPB, GDP-mannose pyrophosphorylase B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 29925
neXtProt AC: NX_Q9Y5P6

Human Synonyms: MDDGA14, MDDGB14, MDDGC14

Human Chr (Location): 3p21.31; chr3:49721476-49723974 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human GMPPB

Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Gmppb interacts with 185 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process biosynthetic process
Component cytoplasm, mitochondrion
Function GTP binding, mannose-1-phosphate guanylyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (97)    Tissues (97)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 97
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gmppb ; ZFIN gmppb    NEW 
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016525 (Evidence)
Ensembl Gene Model ENSMUSG00000070284 (Evidence)
Entrez Gene 331026 (Evidence)
EC 2.7.7.13
Consensus CDS Project CCDS23515.1
International Mouse Phenotyping Consortium Status Gmppb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016525 VEGA Gene Model | MGI Sequence Detail 3560 C57BL/6J ±  kb
transcript OTTMUST00000039937 VEGA | MGI Sequence Detail 1429 Not Applicable 
polypeptide OTTMUSP00000017807 VEGA | MGI Sequence Detail 360 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001451 Hexapeptide repeat
InterPro IPR018357 Hexapeptide transferase, conserved site
InterPro IPR029044 Nucleotide-diphospho-sugar transferases
InterPro IPR005835 Nucleotidyl transferase domain
Protein Ontology PR:000008076 mannose-1-phosphate guanyltransferase beta
References
(Earliest) J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
(Latest) J:149737 Sansom SN, et al., The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun;5(6):e1000511
All references(24)
Other
accession IDs
MGI:2143016

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory